利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.032 秒)

    Microemulsion process and composition
    1.
    发明授权
    Microemulsion process and composition 有权
    微乳液工艺及组成

    公开(公告)号：US08460641B2

    公开(公告)日：2013-06-11

    申请号：US11216668

    申请日：2005-08-31

    申请人： Maria Graziella Larm ,  Ronald Harding ,  Michael Johnston ,  Albert Zorko Abram ,  Prema Vijayakumar ,  Phoebe Sun

    发明人： Maria Graziella Larm ,  Ronald Harding ,  Michael Johnston ,  Albert Zorko Abram ,  Prema Vijayakumar ,  Phoebe Sun

    IPC分类号： A61K9/00 ,  A61K8/02 ,  A61K8/00 ,  A61K31/59 ,  A61K31/56 ,  A01N45/00

    CPC分类号： A61K31/56 ,  A61K8/062 ,  A61K8/068 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/12 ,  A61K31/59 ,  A61Q19/00

    摘要： An oil-in-water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, comprising: a first part including at least one occlusive agent and one or more lipophilic surfactants dispersed throughout a second part including water and at least one hydrophilic surfactant, and a non-surfactant amphiphilic type compound, pharmaceutically active ingredient, and water. It has been found that if a non-surfactant amphiphilic type compound is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.

    摘要翻译： 一种用于皮肤递送至少一种药物活性成分的水包油微乳液或亚微米乳液组合物，其包含：第一部分，其包含至少一种封闭剂和一种或多种分散在包括水的第二部分和在 至少一种亲水性表面活性剂和非表面活性剂两亲型化合物，药物活性成分和水。 已经发现如果将非表面活性剂两亲型化合物与常规情况下的第二部分一起加入，则不形成微乳液或亚微米级乳液，通过加入所谓的第三部分，相组合发生在 比预期的温度更低，此外，该阶段似乎有助于在常温下储存期间维持制剂的微乳液或亚微米乳液特性。