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9 条记录 (耗时 0.017 秒)

    Microemulsion process and composition
    1.
    发明授权
    Microemulsion process and composition 有权
    微乳液工艺及组成

    公开(公告)号：US08460641B2

    公开(公告)日：2013-06-11

    申请号：US11216668

    申请日：2005-08-31

    申请人： Maria Graziella Larm ,  Ronald Harding ,  Michael Johnston ,  Albert Zorko Abram ,  Prema Vijayakumar ,  Phoebe Sun

    发明人： Maria Graziella Larm ,  Ronald Harding ,  Michael Johnston ,  Albert Zorko Abram ,  Prema Vijayakumar ,  Phoebe Sun

    IPC分类号： A61K9/00 ,  A61K8/02 ,  A61K8/00 ,  A61K31/59 ,  A61K31/56 ,  A01N45/00

    CPC分类号： A61K31/56 ,  A61K8/062 ,  A61K8/068 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/12 ,  A61K31/59 ,  A61Q19/00

    摘要： An oil-in-water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, comprising: a first part including at least one occlusive agent and one or more lipophilic surfactants dispersed throughout a second part including water and at least one hydrophilic surfactant, and a non-surfactant amphiphilic type compound, pharmaceutically active ingredient, and water. It has been found that if a non-surfactant amphiphilic type compound is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.

    摘要翻译： 一种用于皮肤递送至少一种药物活性成分的水包油微乳液或亚微米乳液组合物，其包含：第一部分，其包含至少一种封闭剂和一种或多种分散在包括水的第二部分和在 至少一种亲水性表面活性剂和非表面活性剂两亲型化合物，药物活性成分和水。 已经发现如果将非表面活性剂两亲型化合物与常规情况下的第二部分一起加入，则不形成微乳液或亚微米级乳液，通过加入所谓的第三部分，相组合发生在 比预期的温度更低，此外，该阶段似乎有助于在常温下储存期间维持制剂的微乳液或亚微米乳液特性。

    Methods and devices for removing interfering species
    5.
    发明授权
    Methods and devices for removing interfering species 有权
    包含十一碳烯酸酯的水凝胶制剂及其使用方法

    公开(公告)号：US06615078B1

    公开(公告)日：2003-09-02

    申请号：US09556486

    申请日：2000-04-21

    申请人： Kim K. Burson ,  Michelle Van Wyhe ,  Jeffrey Pudlo ,  Michael Reidy ,  Pravin Soni ,  Christopher Uhegbu ,  Prema Vijayakumar

    发明人： Kim K. Burson ,  Michelle Van Wyhe ,  Jeffrey Pudlo ,  Michael Reidy ,  Pravin Soni ,  Christopher Uhegbu ,  Prema Vijayakumar

    IPC分类号： A61N130

    CPC分类号： A61N1/30

    摘要： This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typically take place either during or after the manufacture of the ionically conductive material or an assembly comprising this material. Also disclosed are methods for generating selectively permeable barriers on the reactive faces of electrodes. Further, this invention relates to hydrogels comprising one or more biocides, as well as assemblies containing such hydrogels.

    摘要翻译： 本发明涉及用于减少离子导电材料中化合物的存在的方法，例如用于离子电渗法的装置，其中化合物的存在妨碍检测选定的分析物。 化合物的除去通常可以在离子导电材料制造期间或之后或包含该材料的组合件中进行。 还公开了用于在电极的反应面上产生选择性渗透阻挡层的方法。 此外，本发明涉及包含一种或多种杀生物剂的水凝胶以及含有这种水凝胶的组合物。

    Methods of manufacturing glucose measuring assemblies with hydrogels
    8.
    发明授权
    Methods of manufacturing glucose measuring assemblies with hydrogels 有权
    用水凝胶制造葡萄糖测量组件的方法

    公开(公告)号：US07183068B2

    公开(公告)日：2007-02-27

    申请号：US11060524

    申请日：2005-02-17

    申请人： Kim K. Burson ,  Michelle Van Wyhe ,  Jeffrey Pudlo ,  Michael Reidy ,  Pravin Soni ,  Christopher Uhegbu ,  Prema Vijayakumar

    发明人： Kim K. Burson ,  Michelle Van Wyhe ,  Jeffrey Pudlo ,  Michael Reidy ,  Pravin Soni ,  Christopher Uhegbu ,  Prema Vijayakumar

    IPC分类号： C12Q1/54

    CPC分类号： A61N1/30

    摘要： This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typically take place either during or after the manufacture of the ionically conductive material or an assembly comprising this material. Also disclosed are methods for generating selectively permeable barriers on the reactive faces of electrodes. Further, this invention relates to hydrogels comprising one or more biocides, as well as assemblies containing such hydrogels.

    摘要翻译： 本发明涉及用于减少离子导电材料中化合物的存在的方法，例如用于离子电渗法的装置，其中化合物的存在妨碍检测选定的分析物。 化合物的除去通常可以在离子导电材料制造期间或之后或包含该材料的组合件中进行。 还公开了用于在电极的反应面上产生选择性渗透阻挡层的方法。 此外，本发明涉及包含一种或多种杀生物剂的水凝胶以及含有这种水凝胶的组合物。

    Methods of producing collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems
    9.
    发明授权
    Methods of producing collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems 有权
    生产用于透皮采样系统的收集组件，层压板和自动传感器组件的方法

    公开(公告)号：US06341232B1

    公开(公告)日：2002-01-22

    申请号：US09810917

    申请日：2001-03-16

    申请人： Thomas E. Conn ,  Russell Ford ,  Pravin L. Soni ,  Michael J. Tierney ,  Prema Vijayakumar

    发明人： Thomas E. Conn ,  Russell Ford ,  Pravin L. Soni ,  Michael J. Tierney ,  Prema Vijayakumar

    IPC分类号： A61N130

    CPC分类号： A61B5/1486

    摘要： The invention relates generally to methods of producing consumable components of a device used for measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates methods of producing collection assemblies, laminate structures, and autosensor assemblies, which are used in connection with a transdermal sampling device. In one aspect, the invention includes methods of producing autosensor assemblies which include laminate structures, electrode assemblies, and support trays. One important application of the invention involves methods of producing an autosensor assembly for use in a blood glucose monitoring device.

    摘要翻译： 本发明一般涉及生产用于测量存在于生物系统中的目标化学分析物的浓度的装置的消耗性组分的方法。 更具体地说，本发明涉及生产与经皮采样装置结合使用的收集组件，层压结构和自动传感器组件的方法。 一方面，本发明包括制造包括层压结构，电极组件和支撑托盘的自动传感器组件的方法。 本发明的一个重要应用涉及生产用于血糖监测装置的自动传感器组件的方法。