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1.发明申请DRUG DELIVERY AGENTS COMPRISING CYCLODEXTRIN COVALENTLY LINKED TO A GEMINI SURFACTANT, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 有权含有连接到GEMINI表面活性剂的环糊精的药物递送试剂和包含其的药物组合物公开(公告)号：US20140113977A1
公开(公告)日：2014-04-24
申请号：US14118721
申请日：2012-05-18
申请人： Ildiko Badea , Ronald Verrall , Peng Yang , Marianna Foldvari , Jackson Chitanda , Deborah Michel
发明人： Ildiko Badea , Ronald Verrall , Peng Yang , Marianna Foldvari , Jackson Chitanda , Deborah Michel
IPC分类号： A61K47/40
CPC分类号： A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08B37/0015
摘要： This disclosure relates to cyclodextrin-based drug delivery agents that comprise a cyclodextrin moiety covalently linked to a moiety of a gemini surfactant. Pharmaceutical compositions comprising the drug delivery agent and a therapeutic agent are also disclosed.
摘要翻译： 本公开涉及包含与双子表面活性剂的部分共价连接的环糊精部分的基于环糊精的药物递送剂。 还公开了包含药物递送剂和治疗剂的药物组合物。
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2.发明申请BIPHASIC LIPID-VESICLE COMPOSITION AND METHOD FOR TREATING CERVICAL DYSPLASIA BY INTRAVAGINAL DELIVERY 有权双向脂肪组合物和通过腹腔内输送治疗宫颈粘液的方法公开(公告)号：US20100196453A1
公开(公告)日：2010-08-05
申请号：US12532752
申请日：2008-03-27
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/10 , A61K9/1075 , A61K9/1277 , A61K31/198 , A61K38/21 , A61K38/212 , A61K47/183
摘要： A biphasic lipid vesicle composition for treating cervical displasia by intravaginal delivery. The composition includes a suspension of lipid-bilayer vesicles having entrapped therein, an oil-in-water emulsion, human interferon alpha-2b and L-methionine, the composition having an interferon alpha-2b specific activity of between about 1-10 MIU (million international units) per gram composition, and between 0.01 to 0.5 weight percent L-methionine. In the treatment method, the composition is administered at a dose of between about 1-20 MIU interferon alpha-2b, and this dose is administered at least 3 days/week, for a period of at least 4 weeks.
摘要翻译： 用于通过阴道内递送治疗宫颈置换的双相脂质囊泡组合物。 该组合物包括其中包含的脂质 - 双层囊泡的悬浮液，水包油乳剂，人类干扰素α-2b和L-甲硫氨酸，所述组合物具有约1-10MIU的干扰素α-2b特异活性（ 百万国际单位），和0.01-0.5重量百分比的L-甲硫氨酸。 在治疗方法中，组合物以约1-20MIU干扰素α-2b的剂量施用，并且该剂量至少3天/周施用至少4周的时间。
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公开(公告)号：US06444200B1
公开(公告)日：2002-09-03
申请号：US09730464
申请日：2000-12-04
IPC分类号： A61K3819
摘要： A composition for transdermal administration of a cytokine is described. The composition includes a conjugate composed of a cytokine, such as an interferon, and at least one fatty acid moiety covalently attached to the cytokine. The conjugate has enhanced cutaneous delivery relative to the cytokine alone.
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4.发明授权Drug delivery agents comprising cyclodextrin covalently linked to a gemini surfactant, and pharmaceutical compositions comprising the same 有权共价连接到双子表面活性剂的环糊精的药物递送剂和包含其的药物组合物公开(公告)号：US09168306B2
公开(公告)日：2015-10-27
申请号：US14118721
申请日：2012-05-18
申请人： Ildiko Badea , Ronald Verrall , Peng Yang , Marianna Foldvari , Jackson Chitanda , Deborah Michel
发明人： Ildiko Badea , Ronald Verrall , Peng Yang , Marianna Foldvari , Jackson Chitanda , Deborah Michel
CPC分类号： A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08B37/0015
摘要： This disclosure relates to cyclodextrin-based drug delivery agents that comprise a cyclodextrin moiety covalently linked to a moiety of a gemini surfactant. Pharmaceutical compositions comprising the drug delivery agent and a therapeutic agent are also disclosed.
摘要翻译： 本公开涉及包含与双子表面活性剂的部分共价连接的环糊精部分的基于环糊精的药物递送剂。 还公开了包含药物递送剂和治疗剂的药物组合物。
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公开(公告)号：US20090054368A1
公开(公告)日：2009-02-26
申请号：US12215963
申请日：2008-07-01
IPC分类号： A61K31/711 , A61K47/06 , A61K47/16 , C12Q1/68
CPC分类号： A61K31/711 , A61K9/0014 , A61K9/006 , A61K9/127 , C07C211/62 , C12N15/87 , C12N15/88
摘要： The compositions, systems, and methods relate to substituted and asymmetric gemini surfactants for use in delivering biologically active agents, such as nucleic acids, to a subject. The described compositions, systems, and methods are useful for gene therapy.
摘要翻译： 组合物，体系和方法涉及用于向受试者递送生物活性剂（例如核酸）的取代和不对称双子双表面活性剂。 所描述的组合物，系统和方法可用于基因治疗。
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公开(公告)号：US6165458A
公开(公告)日：2000-12-26
申请号：US216500
申请日：1998-12-18
IPC分类号： A61K9/00 , A61K38/12 , A61K38/19 , A61K38/21 , A61K47/02 , A61K47/26 , A61K47/48 , A61K38/20
CPC分类号： A61K38/1722 , A61K9/0014 , A61K38/1774 , A61K47/02 , A61K47/26 , A61K47/54 , A61K47/542
摘要： A composition for transdermal administration of a cytokine is described. The composition includes a conjugate composed of a cytokine, such as an interferon, and at least one fatty acid moiety covalently attached to the cytokine. The conjugate has enhanced cutaneous delivery relative to the cytokine alone.
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7.发明授权Biphasic lipid vesicle composition for transdermal administration of an immunogen 有权用于透皮给药免疫原的双相脂质囊泡组合物
公开(公告)号：US5993852A
公开(公告)日：1999-11-30
申请号：US141875
申请日：1998-08-27
CPC分类号： A61K9/7084 , A61K39/39 , A61K9/127 , Y10S424/812 , Y10S436/829
摘要： A composition for transdermal administration of an immunogen is described. The immunogen is entrapped in lipid vesicles having a oil-in-water emulsion in the central core compartment. The vesicles are administered transdermally to elicit an immune response in a subject.
摘要翻译： 描述了用于透皮给药免疫原的组合物。 免疫原被夹带在具有水包油乳剂的脂质囊泡中心核心室中。 囊泡经皮施用以在受试者中引发免疫应答。
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公开(公告)号：US5853755A
公开(公告)日：1998-12-29
申请号：US872068
申请日：1997-06-10
申请人： Marianna Foldvari
发明人： Marianna Foldvari
IPC分类号： A61K9/127
CPC分类号： A61K9/0014 , A61K9/127 , Y10T428/2984
摘要： A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises peripheral aqueous solution compartments formed between the lipid bilayers and a central lipophilic core compartment substantially at the center of the multilamellar lipid vesicle.
摘要翻译： 包含多个间隔开的脂质双层的双相多层脂质囊泡，其包含脂质体形成成分和任选地包埋在脂质双层内的生物活性剂。 脂质囊泡还包括在脂质双层和基本上在多层脂质囊泡的中心的中心亲脂性核心隔室之间形成的外围水溶液隔室。
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公开(公告)号：US08945529B2
公开(公告)日：2015-02-03
申请号：US12532752
申请日：2008-03-27
IPC分类号： A61K38/21 , A61K9/127 , A61K38/00 , A61K9/00 , A61K31/198 , A61K47/18 , A61K9/10 , A61K9/107
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/10 , A61K9/1075 , A61K9/1277 , A61K31/198 , A61K38/21 , A61K38/212 , A61K47/183
摘要： A biphasic lipid vesicle composition for treating cervical displasia by intravaginal delivery. The composition includes a suspension of lipid-bilayer vesicles having entrapped therein, an oil-in-water emulsion, human interferon alpha-2b and L-methionine, the composition having an interferon alpha-2b specific activity of between about 1-10 MIU (million international units) per gram composition, and between 0.01 to 0.5 weight percent L-methionine. In the treatment method, the composition is administered at a dose of between about 1-20 MIU interferon alpha-2b, and this dose is administered at least 3 days/week, for a period of at least 4 weeks.
摘要翻译： 用于通过阴道内递送治疗宫颈置换的双相脂质囊泡组合物。 该组合物包括其中包含脂质 - 双层囊泡的悬浮液，水包油乳剂，人类干扰素α-2b和L-甲硫氨酸，所述组合物具有约1-10MIU的干扰素α-2b比活性（ 百万国际单位），和0.01-0.5重量百分比的L-甲硫氨酸。 在治疗方法中，组合物以约1-20MIU干扰素α-2b的剂量施用，并且该剂量至少3天/周施用至少4周的时间。
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10.发明申请DISPERSION AND DEBUNDLING OF CARBON NANOTUBES USING GEMINI SURFACTANT COMPOUNDS 审中-公开使用GEMINI表面活性剂化合物对碳纳米管的分散和去除公开(公告)号：US20110300126A1
公开(公告)日：2011-12-08
申请号：US13128871
申请日：2009-11-11
申请人： Marianna Foldvari
发明人： Marianna Foldvari
CPC分类号： B82Y30/00 , B01F17/005 , B82Y40/00 , C01B32/174 , C01B2202/06 , C01B2202/28 , C01B2202/34 , C01B2202/36
摘要： The current application relates to a method for solubilizing (dispersing and debundling) of carbon nanotubes using a gemini surfactant, which has head groups and a spacer linking the head groups. The dispersion of nanotubes produced by said method can be used as a delivery system for biologically active agents to an organism.
摘要翻译： 目前的应用涉及使用具有头基和连接头基的间隔基的双子表面活性剂增溶（分散和分散）碳纳米管的方法。 通过所述方法产生的纳米管的分散体可用作用于生物体的生物活性剂的递送系统。
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