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1.发明授权Phosphatidylinositol analogues, inhibitors of phosphatidylinositol specific phospholipase C 失效磷脂酰肌醇类似物，磷脂酰肌醇特异性磷脂酶C的抑制剂
公开(公告)号：US5352810A
公开(公告)日：1994-10-04
申请号：US824318
申请日：1992-01-23
申请人： Mario Brufani , Maria Candida Cesta , Enrico Ferrari , Luigi Filocamo , Sperandina Lappa , Stefano Maiorana , Pier Giuseppe Pagella
发明人： Mario Brufani , Maria Candida Cesta , Enrico Ferrari , Luigi Filocamo , Sperandina Lappa , Stefano Maiorana , Pier Giuseppe Pagella
IPC分类号： A61K31/66 , A61P7/02 , A61P29/00 , A61P35/00 , C07F9/117 , C07F9/165 , C07F9/17 , C07F9/177 , C12N9/99 , C07F9/02
摘要： Phosphatidylinositol analogues, inhibitors of phosphatidylinositol-specific phospholipase C of general formula (I) ##STR1## wherein X and R have the meanings specified in the description, suitable for preparing pharmaceutical compositions for the treatment of tumoral, thrombotic and inflammatory type pathologies.
摘要翻译： 磷脂酰肌醇类似物，通式（I）的磷脂酰肌醇特异性磷脂酶C的抑制剂其中X和R具有本说明书中规定的含义，适用于制备用于治疗肿瘤，血栓和炎症型病理学的药物组合物 。
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2.发明授权Aminoalkylcarbamic esters of eseroline suitable for use as chlorinesterase activity inhibitors 失效适合用作氯仿酯酶活性抑制剂的eseroline的氨基烷基氨基甲酸酯
公开(公告)号：US5302593A
公开(公告)日：1994-04-12
申请号：US79921
申请日：1993-06-23
申请人： Maria A. Alisi , Mario Brufani , Maria C. Cesta , Luigi Filocamo , Gianluca Gostoli , Sperandina Lappa , Pier Giuseppe Pagella , Enrico Ferrari , Stefano Maiorana , Donata Marchesini
发明人： Maria A. Alisi , Mario Brufani , Maria C. Cesta , Luigi Filocamo , Gianluca Gostoli , Sperandina Lappa , Pier Giuseppe Pagella , Enrico Ferrari , Stefano Maiorana , Donata Marchesini
IPC分类号： A61K31/40 , A61K31/415 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61P21/00 , A61P25/02 , A61P25/28 , C07D487/04 , C07D519/00 , C07D413/12 , C07D417/12
CPC分类号： C07D487/04
摘要： Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting of ##STR2## and n, R1, R2, R3, and R4 are as defined in the text.
摘要翻译： 适合用作胆碱酯酶活性抑制剂的eseroline的氨基烷基氨基甲酸酯，具有通式（I）（* CHEMICAL STRUCTURE *）（I）其中R代表选自（*化学结构*）（*化学结构） *）（*化学结构*）（*化学结构*），n，R1，R2，R3和R4如文中所定义。
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公开(公告)号：US5424451A
公开(公告)日：1995-06-13
申请号：US177325
申请日：1994-01-04
申请人： Maria A. Alisi , Mario Brufani , Maria C. Cesta , Luigi Eieocamo , Gianluca Gostoli , Sperandina Lappa , Pier Giuseppe Pagella , Enrico Ferrari , Stefano Maiorana , Donata Marchesini
发明人： Maria A. Alisi , Mario Brufani , Maria C. Cesta , Luigi Eieocamo , Gianluca Gostoli , Sperandina Lappa , Pier Giuseppe Pagella , Enrico Ferrari , Stefano Maiorana , Donata Marchesini
IPC分类号： A61K31/40 , A61K31/415 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61P21/00 , A61P25/02 , A61P25/28 , C07D487/04 , C07D519/00 , C07D209/58
CPC分类号： C07D487/04
摘要： Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting of ##STR2## and n, R1, R2, R3, and R4 are as defined in the text.
摘要翻译： 适用于胆碱酯酶活性抑制剂的西伐林的氨基烷基氨基甲酸酯，具有通式（I）其中R表示选自下列的组中选择的胺：（1）IMAGE>
在文中。 -
4.发明授权
公开(公告)号：US5214180A
公开(公告)日：1993-05-25
申请号：US821088
申请日：1992-01-16
摘要： Phosphatidylinositol of high purity useful for the treatment of central nervous system disorders, prepared from vegetal substances containing it by treating them with reagents suitable for the functionalization of the inositol hydroxy group with protective groups, separating the thus protected phosphatidylinositol by solvent extraction or chromatography, and finally removing said protective groups under conditions which do not modify the phosphatidyl group.
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5.发明授权Phenylcarbamate derivatives suitable to the use as anticholinesterase substances 失效苯基氨基甲酸酯衍生物适合用作抗胆碱酯酶物质
公开(公告)号：US5869484A
公开(公告)日：1999-02-09
申请号：US776052
申请日：1997-01-17
申请人： Patrizia Terni , Lucia Mairani , Giacomina Mandelli , Pier Giuseppe Pagella , Donata Marchesini , Stefano Maiorana , Mario Brufani
发明人： Patrizia Terni , Lucia Mairani , Giacomina Mandelli , Pier Giuseppe Pagella , Donata Marchesini , Stefano Maiorana , Mario Brufani
IPC分类号： C07C271/44 , C07C271/56 , C07C271/58 , C07D239/95 , C07D295/13 , C07D295/185 , C07D491/113 , A61K31/535 , C07D265/30 , C07D265/32 , C07D413/00
CPC分类号： C07D295/185 , C07C271/44 , C07C271/56 , C07C271/58 , C07D239/95 , C07D295/13 , C07C2101/14
摘要： Phenylcarbamate derivatives suitable to the use as anticholinesterase substances having the general formula (I) ##STR1## wherein the meaning of R.sub.1 -R.sub.7 and X substituentes together with n will be defined in the text.
摘要翻译： PCT No.PCT / EP95 / 02752 Sec。 371日期1997年1月17日 102（e）日期1997年1月17日PCT提交1995年7月13日PCT公布。 公开号WO96 / 02524 日期：1996年2月1日适用于具有通式（I）的抗胆碱酯酶物质的苯基氨基甲酸酯衍生物，其中R1和R7的取代基与n的含义将在文中定义。
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公开(公告)号：US4978673A
公开(公告)日：1990-12-18
申请号：US172799
申请日：1988-03-28
申请人： Carlo Meroni , Stefano Maiorana , Mario Brufani , Massimo Pomponi , Riccardo Bernardi , Pier L. Rugarli , Pier G. Pagella
发明人： Carlo Meroni , Stefano Maiorana , Mario Brufani , Massimo Pomponi , Riccardo Bernardi , Pier L. Rugarli , Pier G. Pagella
IPC分类号： A61K31/40 , A61P21/00 , A61P25/02 , C07C57/145 , C07C59/255 , C07C59/265 , C07D487/04
CPC分类号： C07D487/04 , C07C57/145 , C07C59/255 , C07C59/265
摘要： Organic salts of physostigmine derivatives, having the following general mula: ##STR1## in which R is a linear or branched C.sub.2 -C.sub.12 alkyl or a cycloalkyl or an aryl, and X.sub.- is the anion of an organic acid, the process for their preparation and their pharmaceutical use for acetylcholinesterase inhibition purposes.
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公开(公告)号：US20100137644A1
公开(公告)日：2010-06-03
申请号：US12599043
申请日：2008-05-06
申请人： Antonio Nardi , Mara Sada , Annibale Salvi , Stefano Maiorana
发明人： Antonio Nardi , Mara Sada , Annibale Salvi , Stefano Maiorana
IPC分类号： C07C45/61
摘要： The invention concerns a new process for the preparation of naphthoquinones, in particular an improved process for the preparation of 2,3-disubstituted 1,4-naphthoquinones, in the trans configuration.
摘要翻译： 本发明涉及用于制备萘醌的新方法，特别是在反式构型中制备2,3-二取代的1,4-萘醌的改进方法。
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8.发明授权Process for preparing pyrido-benzothiazine derivatives having high antibacterial activity and high bioavailability to tissues 失效制备具有高抗细菌活性和高组织生物可利用性的吡咯并苯并噻嗪衍生物的方法
公开(公告)号：US5066802A
公开(公告)日：1991-11-19
申请号：US447406
申请日：1989-12-07
IPC分类号： A61K31/54 , A61P31/04 , C07D513/06
CPC分类号： C07D513/06
摘要： A process for preparing pyrido-benzothiazine derivatives having the following general formula: ##STR1## in which R is H or a C.sub.1 -C.sub.6 alkyl or a C.sub.1 -C.sub.6 fluoroalkyl, and R.sub.1 is N-alkyl-3-pyrrolidinalkylamine with C.sub.1 to C.sub.6 alkyls or ##STR2## where R.sub.2 is a C.sub.1 -C.sub.6 alkyl or a C.sub.2 -C.sub.6 alkenyl or an arylalkyl group, possibly substituted by halogen, hydroxy or keto-groups, both in the racemic form and in the optically active form. The process for the preparation of derivatives of formula (I) starts with a first reaction cycle starting from 2,4-difluoro-3-chloronitrobenzene. Said derivatives possess a high antibacterial activity as well as a high bioavailability to tissues. The invention also refers to pharmaceutical compositions containing them as active components.
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公开(公告)号：US08324411B2
公开(公告)日：2012-12-04
申请号：US12811423
申请日：2008-12-19
申请人： Annibale Salvi , Antonio Nardi , Stefano Maiorana , Mara Sada
发明人： Annibale Salvi , Antonio Nardi , Stefano Maiorana , Mara Sada
IPC分类号： C07C49/593
CPC分类号： C07C66/02 , C07C67/24 , C07C2603/24 , C07C69/16
摘要： The invention concerns a new process for the preparation of high purity diacerein, by oxidization of the protected aloe-emodin in the presence of an oxidizing system and radical catalyst and subsequent substitution of the protector groups with acetyl groups.
摘要翻译： 本发明涉及通过在氧化体系和自由基催化剂的存在下氧化保护的芦荟大黄素并随后用乙酰基取代保护基团来制备高纯度双醋瑞因的新方法。
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10.发明授权Pyrido-benzothiazine derivatives having high antibacterial activity and high bioavailability to tissues 失效吡啶并苯并噻嗪衍生物对组织具有高抗菌活性和高生物利用度
公开(公告)号：US4923859A
公开(公告)日：1990-05-08
申请号：US251457
申请日：1988-09-30
IPC分类号： A61K31/54 , A61P31/04 , C07D513/06
CPC分类号： C07D513/06
摘要： Pyrido-benzothiazine derivatives having the following general formula: ##STR1## in which R is H or a C.sub.1 -C.sub.6 alkyl or a C.sub.1 -C.sub.6 fluoroalkyl, and R.sub.1 is N-alkyl-3-pyrrolidinalkylamine with C.sub.1 to C.sub.6 alkyls or ##STR2## where R.sub.2 is a S.sub.1 -C.sub.6 alkyl or a C.sub.2 -C.sub.6 alkenyl or an arylalkyl group, possibly substituted by halogen, hydroxy or keto-groups, both in the racemic form and in the optically active form.The invention also comprises the process for the preparation of derivatives of formula (I) starting from 2.4-difluoro-3-chloronitrobenzene.Said derivatives possess a high antibacterial acitvity as well as a high bioavailability to tissues; the invention also refers to pharmaceutical compositions containing them as active components.
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