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    Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use
    9.
    发明授权
    Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use 失效
    哌啶，四氢吡啶和哌嗪衍生物，其制备和用途

    公开(公告)号：US06596722B2

    公开(公告)日：2003-07-22

    申请号：US09901585

    申请日：2001-07-09

    申请人： Ejner Knud Moltzen ,  Christian Krog-Jensen ,  Berith Bjørnholm

    发明人： Ejner Knud Moltzen ,  Christian Krog-Jensen ,  Berith Bjørnholm

    IPC分类号： C07D41114

    CPC分类号： C07D405/12 ,  C07D307/81 ,  C07D319/18 ,  C07D405/14 ,  C07D407/12 ,  C07D413/12

    摘要： A piperidine, tetrahydropyridine or piperazine derivative having formula (I), any of its enantiomers or any mixture thereof, or an acid addition salt thereof, wherein B is C1-10-alkylene, C1-10-alkenylene or C1-10-alkynylene; X is —O—, —S—, or CR4R5—; and Y is —CR6R7, —CR6R7—CR8R9, or CR6═CR7—; or X and Y together form a group —CR4═CR5, or —CR4—CR5—CR6R7-; Z is —O—, or —S—; W is N, C, or CH, and the dotted line is an optional bond; A is a bicyclic ring selected from (Ia) or (Ib) wherein E1, E2 and E3 are selected from O, S, N, NR11, C, CR12 and CHR13, and the dotted line indicates an optional bond, provided that E2 and E1 and/or E3 may not simultaneously be O, or S. The compounds of the invention are considered useful for the treatment of affective disorders, such as depression, psychosis, anxiety disorders including general anxiety disorder, panic disorder, obsessive compulsive disorder, and eating disorders.

    摘要翻译： 具有式（I）的哌啶，四氢吡啶或哌嗪衍生物，其任何对映异构体或其任何混合物或其酸加成盐，其中B为C1-10亚烷基，C1-10亚烯基或C1-10亚炔基; X是-O-，-S-或CR 4 R 5 - ; 且Y为-CR 6 R 7，-CR 6 R 7 -CR 8 R 9或CR 6 = CR 7 - ; 或X和Y一起形成-CR4 = CR5或-CR4-CR5-CR6R7-; Z是-O-或-S-; W是N，C或CH，虚线是任选的键; A是选自（Ia）或（Ib）的双环，其中E1，E2和E3选自O，S，N，NR11，C，CR12和CHR13，虚线表示任选的键，条件是E2和 E1和/或E3可能不能同时为O或S.本发明的化合物被认为可用于治疗情感障碍，例如抑郁症，精神病，焦虑症，包括一般焦虑症，恐慌症，强迫症，和强迫症 饮食失调。