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1.发明申请Polymorphisms Associated With Age-Related Macular Degeneration And Methods For Evaluating Patient Risk 审中-公开与年龄相关性黄斑变性相关的多态性和评估患者风险的方法公开(公告)号：US20110177957A1
公开(公告)日：2011-07-21
申请号：US12988340
申请日：2009-04-17
Applicant: Johanna M. Seddon , Mark Daly
Inventor： Johanna M. Seddon , Mark Daly
CPC classification number: C12Q1/6883 , C12Q2600/156 , C12Q2600/172
Abstract: The present invention provides for certain polynucleotide sequences that have been correlated to AMD. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an array, useful for screening patient samples. The array is used as part of a laboratory information management system, to store and process additional patient information in addition to the patient's genomic profile. As described herein, the system provides an assessment of the patient's risk for developing AMD, risk for disease progression, and the likelihood of disease prevention based on patient controllable factors.
Abstract translation: 本发明提供了与AMD相关的某些多核苷酸序列。 这些多核苷酸可用作诊断，并且优选用于制备用于筛选患者样品的阵列。 该阵列用作实验室信息管理系统的一部分，用于存储和处理除患者基因组谱外的其他患者信息。 如本文所述，系统提供对患者开发AMD的风险，疾病进展风险以及基于患者可控因素的预防疾病的可能性的评估。
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公开(公告)号：US06869762B1
公开(公告)日：2005-03-22
申请号：US09735271
申请日：2000-12-11
Applicant: Mark Daly , Thomas J. Hudson , Eric S. Lander , John Rioux , Kathy Siminovitch
Inventor： Mark Daly , Thomas J. Hudson , Eric S. Lander , John Rioux , Kathy Siminovitch
CPC classification number: C12Q1/6883 , C12Q2600/156
Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.
Abstract translation: 本发明提供人基因组的核酸片段，特别是来自基因的核酸片段，包括多态位点。 还提供了与侧翼或含有这些位点的区域杂交的等位基因特异性引物和探针。 核酸，引物和探针用于表型相关性，取证，亲子鉴定，药物和遗传分析等应用中。
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公开(公告)号：US20100157733A1
公开(公告)日：2010-06-24
申请号：US12342325
申请日：2008-12-23
Applicant: Mark Daly
Inventor： Mark Daly
IPC: G01V1/28
CPC classification number: G01V1/37
Abstract: A technique includes modeling a fundamental component of a vibroseis sweep that is injected into the earth based on a ground force measurement and a reference sweep. The technique includes determining an operator to compensate seismic data acquired in response to the injected vibroseis sweep based at least in part on the reference sweep and the fundamental component, and the technique includes applying the operator to the seismic data.
Abstract translation: 一种技术包括对基于地面力测量和参考扫描注入地球的可控震源扫描的基本分量建模。 该技术包括确定操作者以至少部分地基于参考扫描和基本分量来补偿响应于注入的可控震源扫描获取的地震数据，并且该技术包括将操作者应用于地震数据。
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公开(公告)号：US20080319176A1
公开(公告)日：2008-12-25
申请号：US12036960
申请日：2008-02-25
Applicant: Daniel Gaudet , John D. Rioux , Steve Arsenault , Thomas J. Hudson , Mark Daly
Inventor： Daniel Gaudet , John D. Rioux , Steve Arsenault , Thomas J. Hudson , Mark Daly
IPC: C07H21/00
CPC classification number: C12N9/1205 , C12Q1/48 , C12Q1/485 , C12Q1/6883 , C12Q2600/156 , C12Y207/0103 , G01N33/66 , G01N33/6893 , G01N2333/91215 , G01N2500/00 , G01N2800/042 , G01N2800/52
Abstract: Novel alterations in the glycerol kinase gene are described. Also described are methods of predicting or assisting in the prediction of impaired glucose tolerance and type 2 diabetes mellitus.
Abstract translation: 描述了甘油激酶基因的新的改变。 还描述了预测或辅助预测葡萄糖耐量异常和2型糖尿病的方法。
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公开(公告)号：US20060278034A1
公开(公告)日：2006-12-14
申请号：US11151383
申请日：2005-06-13
Applicant: Mark Daly , John Schroeder
Inventor： Mark Daly , John Schroeder
IPC: B62D1/04
CPC classification number: F16F9/06 , B62D1/06 , B62D7/222 , F16F7/1034 , Y10T74/20834
Abstract: A steering wheel assembly having a tuned absorber for damping a vibration of a motor vehicle. The steering wheel assembly has a hub and a substantially circular rim connected to the hub by a plurality of spokes extending between the hub and the rim. A hollow tube is affixed to an interior portion of the rim. A rigid plug is inside the hollow tube. A fluid substance is inside the hollow tube. A gaseous substance is inside the hollow tube. The gaseous substance is interposed between the fluid substance and the rigid plug.
Abstract translation: 一种具有用于阻尼机动车振动的调谐吸收器的方向盘组件。 方向盘组件具有轮毂和通过在轮毂和轮辋之间延伸的多个轮辐连接到轮毂的大致圆形的轮缘。 中空管固定在轮辋的内部。 中空管内有一个刚性塞。 流体物质在中空管内。 气体物质在中空管内。 气体物质介于流体物质和刚性塞子之间。
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Patent Agency Ranking
公开(公告)号：US06743579B1
公开(公告)日：2004-06-01
申请号：US09694088
申请日：2000-10-20
Applicant: Daniel Gaudet , John D. Rioux , Steve Arsenault , Thomas J. Hudson , Mark Daly
Inventor： Daniel Gaudet , John D. Rioux , Steve Arsenault , Thomas J. Hudson , Mark Daly
IPC: C12Q168
CPC classification number: C12N9/1205 , C12Q1/48 , C12Q1/485 , C12Q1/6883 , C12Q2600/156 , C12Y207/0103 , G01N33/66 , G01N33/6893 , G01N2333/91215 , G01N2500/00 , G01N2800/042 , G01N2800/52
Abstract: Novel alterations in the glycerol kinase gene are described. Also described are methods of predicting or assisting in the prediction of impaired glucose tolerance and type 2 diabetes mellitus.
Abstract translation: 描述了甘油激酶基因的新的改变。 还描述了预测或辅助预测葡萄糖耐量异常和2型糖尿病的方法。
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7.发明申请公开(公告)号：US20140309125A1
公开(公告)日：2014-10-16
申请号：US14101915
申请日：2013-12-10
Applicant: Johanna M. Seddon , Mark Daly
Inventor： Johanna M. Seddon , Mark Daly
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N2333/92 , G01N2800/164
Abstract: Described herein are compositions, kits and methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular lipid metabolism markers associated with AMD. Predictive computer models of disease risk are also disclosed.
Abstract translation: 本文描述的是通过检测与AMD相关的特定脂质代谢标记的存在或不存在来诊断和跟踪受试者中AMD进展的组合物，试剂盒和方法。 疾病风险预测计算机模型也被披露。
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8.发明申请公开(公告)号：US20140087960A1
公开(公告)日：2014-03-27
申请号：US13992378
申请日：2011-12-14
Applicant: Johanna M. Seddon , Mark Daly
Inventor： Johanna M. Seddon , Mark Daly
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/156 , C12Q2600/172
Abstract: Methods are provided of screening for age-related macular degeneration (AMD), including a risk of a subject devel - oping AMD or a risk of a subject progressing to an advanced fom of AMD. The methods can include analyzing a sample obtained from the subject for the presence of at least one single nucleotide polymorphism (SNP) selected from the group consisting of rs4711751, rs6982567, rs1999930, rs13278062, rs1912795, rs2270637, rs12040406, rs1367068, rs1079982, rs1443179, rs7720497, and/or rs6 1800454.
Abstract translation: 提供筛查年龄相关性黄斑变性（AMD）的方法，包括发生AMD的受试者风险或患者进展为AMD先进的风险。 所述方法可以包括分析从受试者获得的至少一种选自以下的单核苷酸多态性（SNP）的存在：rs4711751，rs6982567，rs1999930，rs13278062，rs1912795，rs2270637，rs12040406，rs1367068，rs1079982，rs1443179， rs7720497和/或rs6 1800454。
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9.发明申请公开(公告)号：US20120046189A1
公开(公告)日：2012-02-23
申请号：US13260457
申请日：2010-03-26
Applicant: Johanna M. Seddon , Mark Daly
Inventor： Johanna M. Seddon , Mark Daly
CPC classification number: C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N2333/92 , G01N2800/164
Abstract: Described herein are compositions, kits and methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular lipid metabolism markers associated with AMD. Predictive computer models of disease risk are also disclosed.
Abstract translation: 本文描述的是通过检测与AMD相关的特定脂质代谢标记的存在或不存在来诊断和跟踪受试者中AMD进展的组合物，试剂盒和方法。 疾病风险预测计算机模型也被披露。
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公开(公告)号：US09128207B2
公开(公告)日：2015-09-08
申请号：US12342325
申请日：2008-12-23
Applicant: Mark Daly
Inventor： Mark Daly
CPC classification number: G01V1/37
Abstract: A technique includes modeling a fundamental component of a vibroseis sweep that is injected into the earth based on a ground force measurement and a reference sweep. The technique includes determining an operator to compensate seismic data acquired in response to the injected vibroseis sweep based at least in part on the reference sweep and the fundamental component, and the technique includes applying the operator to the seismic data.
Abstract translation: 一种技术包括对基于地面力测量和参考扫描注入地球的可控震源扫描的基本分量建模。 该技术包括确定操作者以至少部分地基于参考扫描和基本分量来补偿响应于注入的可控震源扫描获取的地震数据，并且该技术包括将操作者应用于地震数据。
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