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公开(公告)号：US20050186663A1
公开(公告)日：2005-08-25
申请号：US10872898
申请日：2004-06-21
申请人： Mark Davies , Christopher Phelps , Richard Fagan , Christine Power , Melanie Yorke , Mark Ibberson
发明人： Mark Davies , Christopher Phelps , Richard Fagan , Christine Power , Melanie Yorke , Mark Ibberson
IPC分类号： A01K67/027 , A61K38/00 , A61K39/00 , A61P3/00 , A61P9/00 , A61P25/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , C07H21/04 , C07K14/475 , C07K14/52 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53
摘要： This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种新型蛋白质（INSP002），其被鉴定为分泌型蛋白质，其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员，并且使用该蛋白质和来自编码基因的核酸序列 诊断，预防和治疗疾病。
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公开(公告)号：US20070155958A1
公开(公告)日：2007-07-05
申请号：US10557400
申请日：2003-05-21
申请人： Stephen Fitzgerald , Richard Fagan , Christopher Phelps , Christine Power , Mark Ibberson , Melanie Yorke
发明人： Stephen Fitzgerald , Richard Fagan , Christopher Phelps , Christine Power , Mark Ibberson , Melanie Yorke
CPC分类号： A01K2217/075 , A61K38/00 , C07K14/472 , C07K14/525
摘要： This invention relates to novel protein INSP058, herein identified as TNF-like secreted protein, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及本文鉴定为TNF-样分泌蛋白的新型蛋白质INSP058，以及该蛋白质和来自编码基因的核酸序列在疾病的诊断，预防和治疗中的用途。
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公开(公告)号：US20100048467A1
公开(公告)日：2010-02-25
申请号：US12159541
申请日：2006-01-12
申请人： Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson , Yan Lavrovsky
发明人： Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson , Yan Lavrovsky
IPC分类号： A61K38/16 , A61K31/7088 , A61P35/00
CPC分类号： A61K38/18
摘要： This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种新型蛋白质（INSP002），其被鉴定为分泌型蛋白质，其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员，并且使用该蛋白质和来自编码基因的核酸序列 诊断，预防和治疗疾病。
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公开(公告)号：US07619065B2
公开(公告)日：2009-11-17
申请号：US10872898
申请日：2004-06-21
申请人： Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson
发明人： Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson
摘要： This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种新型蛋白质（INSP002），其被鉴定为分泌型蛋白质，其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员，并且使用该蛋白质和来自编码基因的核酸序列 诊断，预防和治疗疾病。
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公开(公告)号：US07514533B2
公开(公告)日：2009-04-07
申请号：US10557400
申请日：2003-05-21
申请人： Stephen Noel Fitzgerald , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Mark Ibberson , Melanie Yorke
发明人： Stephen Noel Fitzgerald , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Mark Ibberson , Melanie Yorke
CPC分类号： A01K2217/075 , A61K38/00 , C07K14/472 , C07K14/525
摘要： This invention relates to novel protein INSP058, herein identified as TNF-like secreted protein, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及本文鉴定为TNF-样分泌蛋白的新型蛋白质INSP058，以及该蛋白质和来自编码基因的核酸序列在疾病的诊断，预防和治疗中的用途。
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公开(公告)号：US20060080744A1
公开(公告)日：2006-04-13
申请号：US10530104
申请日：2003-09-29
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/00
摘要： The present invention discloses open reading frames (ORFs) in human genome encoding for novel chemokines-like polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and antagonists directed against them. The invention provides methods for identifying and making these molecules, for preparing pharmaceutical compositions containing them, and for using them in the diagnosis, prevention and treatment of diseases.
摘要翻译： 本发明公开了编码新型趋化因子样多肽的人类基因组中的开放阅读框（ORF），以及与其相关的试剂，包括所述多肽的变体，突变体和片段，以及针对它们的配体和拮抗剂。 本发明提供了用于鉴定和制备这些分子的方法，用于制备含有它们的药物组合物，并用于诊断，预防和治疗疾病。
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