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公开(公告)号:US20100048467A1
公开(公告)日:2010-02-25
申请号:US12159541
申请日:2006-01-12
申请人: Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson , Yan Lavrovsky
发明人: Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson , Yan Lavrovsky
IPC分类号: A61K38/16 , A61K31/7088 , A61P35/00
CPC分类号: A61K38/18
摘要: This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及一种新型蛋白质(INSP002),其被鉴定为分泌型蛋白质,其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员,并且使用该蛋白质和来自编码基因的核酸序列 诊断,预防和治疗疾病。
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公开(公告)号:US07619065B2
公开(公告)日:2009-11-17
申请号:US10872898
申请日:2004-06-21
申请人: Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson
发明人: Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson
摘要: This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及一种新型蛋白质(INSP002),其被鉴定为分泌型蛋白质,其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员,并且使用该蛋白质和来自编码基因的核酸序列 诊断,预防和治疗疾病。
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公开(公告)号:US07514533B2
公开(公告)日:2009-04-07
申请号:US10557400
申请日:2003-05-21
申请人: Stephen Noel Fitzgerald , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Mark Ibberson , Melanie Yorke
发明人: Stephen Noel Fitzgerald , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Mark Ibberson , Melanie Yorke
CPC分类号: A01K2217/075 , A61K38/00 , C07K14/472 , C07K14/525
摘要: This invention relates to novel protein INSP058, herein identified as TNF-like secreted protein, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及本文鉴定为TNF-样分泌蛋白的新型蛋白质INSP058,以及该蛋白质和来自编码基因的核酸序列在疾病的诊断,预防和治疗中的用途。
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公开(公告)号:US07531508B2
公开(公告)日:2009-05-12
申请号:US10537142
申请日:2003-12-05
申请人: Richard Joseph Fagan , Christopher Benjamin Phelps , Tania Maria Rodrigues , Melanie Yorke , Mariastella De Tiani
发明人: Richard Joseph Fagan , Christopher Benjamin Phelps , Tania Maria Rodrigues , Melanie Yorke , Mariastella De Tiani
IPC分类号: A61K38/27 , C07K14/475
CPC分类号: C07K14/61 , A01K2217/05 , A01K2217/075
摘要: This invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及一种称为INSP101的新型蛋白质,在本文中被鉴定为人垂体生长激素的新型剪接变体,以及在诊断,预防和治疗疾病中使用该蛋白质和来自编码基因的核酸序列。
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公开(公告)号:US20090042775A1
公开(公告)日:2009-02-12
申请号:US10539656
申请日:2004-01-13
CPC分类号: C07K14/4723
摘要: This invention relates to novel proteins, termed INSP 108 and INSP 109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP 108和INSP 109的新型蛋白质,其在本文中被鉴定为蛋白质防卫素家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20090324562A1
公开(公告)日:2009-12-31
申请号:US12494875
申请日:2009-06-30
CPC分类号: C07K14/4723
摘要: This invention relates to the novel proteins, termed INSP108 and INSP109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP108和INSP109的新型蛋白质,其在本文中被鉴定为蛋白防御素家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US07563767B2
公开(公告)日:2009-07-21
申请号:US10539656
申请日:2004-01-13
IPC分类号: A61K38/17 , C07K14/435 , C12P21/02
CPC分类号: C07K14/4723
摘要: This invention relates to novel proteins, termed INSP 108 and INSP 109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP 108和INSP 109的新型蛋白质,其在本文中被鉴定为蛋白质防卫素家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20080196113A1
公开(公告)日:2008-08-14
申请号:US11577266
申请日:2005-10-14
IPC分类号: A01K67/027 , C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/775
摘要: The invention is based on the discovery that the human protein referred to herein as INSP153 protein is a lipocalin.
摘要翻译: 本发明基于这样的发现,即本文称为INSP153蛋白的人蛋白质是脂质运载蛋白。
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公开(公告)号:US07700724B2
公开(公告)日:2010-04-20
申请号:US10573936
申请日:2004-10-27
申请人: Stephen Noel Fitzgerald , Richard Joseph Fagan , Christine Power , Melanie Yorke , Jadwiga Bienkowska
发明人: Stephen Noel Fitzgerald , Richard Joseph Fagan , Christine Power , Melanie Yorke , Jadwiga Bienkowska
CPC分类号: C07K14/525 , A01K2217/05 , A01K2217/075 , A01K2267/03 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/472 , C07K2319/21
摘要: This invention relates to the novel protein, termed INSP163, herein identified as a secreted protein containing a jelly-roll fold, in particular, as a member of the TNF (tumor necrosis factor)-like family of cytokines, specifically as a C1q-like protein and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP163的新型蛋白质,其在本文中被鉴定为含有胶卷折叠物的分泌蛋白质,特别是作为TNF(肿瘤坏死因子)样细胞因子家族的成员,特别是作为C1q样 蛋白质和使用该蛋白质和核酸序列的编码基因进行诊断,预防和治疗疾病。
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公开(公告)号:US20080213286A1
公开(公告)日:2008-09-04
申请号:US11577443
申请日:2005-10-18
IPC分类号: A61K39/395 , C07K14/00 , C12N15/11 , C12N9/00 , A61K31/70 , A61K38/00 , A61K39/00 , A61P43/00 , C12Q1/68 , G01N33/53 , A01K67/027 , C12N15/00 , C12N5/06 , C07K16/18
CPC分类号: C12N9/6489 , C12N9/16
摘要: This invention relates to a novel protein, termed INSP152, herein identified as a secreted protein, in particular, as a MAM domain containing protein and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment.
摘要翻译: 本发明涉及一种称为INSP152的新型蛋白质,在本文中鉴定为分泌蛋白,特别是含有MAM结构域的蛋白质,以及在诊断,预防和治疗中使用该蛋白质和编码基因的核酸序列。
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