公开(公告)号：US20180111894A1

公开(公告)日：2018-04-26

申请号：US15846198

申请日：2017-12-18

申请人： Mark G. DeGiacomo

发明人： Hassan Pajouhesh ,  Richard Holland ,  Lingyun Zhang ,  Hossein Pajouhesh ,  Jason Lamontagne ,  Brendan Whelan

IPC分类号： C07C237/06 ,  C07C237/22 ,  C07D265/30 ,  C07D231/14 ,  C07C237/04 ,  C07D241/08 ,  C07D413/06 ,  C07D401/12 ,  C07D205/04 ,  C07D413/04 ,  C07D403/06 ,  C07D403/04 ,  C07D401/04 ,  C07D235/14 ,  C07D211/60 ,  C07D207/16 ,  C07C237/24

CPC分类号： C07C237/06 ,  A61K31/401 ,  A61K31/454 ,  A61K31/5377 ,  C07C237/04 ,  C07C237/22 ,  C07C237/24 ,  C07C2601/02 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D231/14 ,  C07D235/14 ,  C07D241/08 ,  C07D265/30 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D413/06

摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) and in particular Formula (X), and Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.

公开(公告)号：US20170260130A1

公开(公告)日：2017-09-14

申请号：US15602089

申请日：2017-05-22

申请人： Mark G. DeGiacomo

发明人： Hassan Pajouhesh ,  Richard Holland ,  Lingyun Zhang ,  Hossein Pajouhesh ,  Jason Lamontagne ,  Brendan Whelan

IPC分类号： C07C237/06 ,  C07D207/16 ,  C07D211/60 ,  C07D235/14 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D205/04 ,  C07D401/12 ,  C07D413/06 ,  C07D241/08 ,  C07C237/04 ,  C07D231/14 ,  C07D265/30 ,  C07C237/22 ,  C07C237/24

CPC分类号： C07C237/06 ,  A61K31/401 ,  A61K31/454 ,  A61K31/5377 ,  C07C237/04 ,  C07C237/22 ,  C07C237/24 ,  C07C2601/02 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D231/14 ,  C07D235/14 ,  C07D241/08 ,  C07D265/30 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D413/06

摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.

公开(公告)号：US10351514B2

公开(公告)日：2019-07-16

申请号：US15846198

申请日：2017-12-18

申请人： Mark G. DeGiacomo

发明人： Hassan Pajouhesh ,  Richard Holland ,  Lingyun Zhang ,  Hossein Pajouhesh ,  Jason Lamontagne ,  Brendan Whelan

IPC分类号： A61K31/401 ,  A61K31/454 ,  A61K31/5377 ,  C07C237/06 ,  C07C237/22 ,  C07C237/24 ,  C07D207/16 ,  C07D211/60 ,  C07D235/14 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D205/04 ,  C07D401/12 ,  C07D413/06 ,  C07C237/04 ,  C07D231/14 ,  C07D265/30 ,  C07D241/08

摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) and in particular Formula (X), and Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.

公开(公告)号：US09688615B2

公开(公告)日：2017-06-27

申请号：US14833601

申请日：2015-08-24

申请人： Mark G. DeGiacomo

发明人： Hassan Pajouhesh ,  Richard Holland ,  Lingyun Zhang ,  Hossein Pajouhesh ,  Jason Lamontagne ,  Brendan Whelan

IPC分类号： C07D207/16 ,  C07D205/04 ,  C07D265/30 ,  C07D231/14 ,  C07D211/60 ,  C07C237/04 ,  C07C237/06 ,  C07C237/22 ,  C07C237/24 ,  C07D235/14 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D401/12 ,  C07D413/06 ,  C07D241/08

CPC分类号： C07C237/06 ,  C07C237/04 ,  C07C237/22 ,  C07C237/24 ,  C07C2601/02 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D231/14 ,  C07D235/14 ,  C07D241/08 ,  C07D265/30 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D413/06

摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.

公开(公告)号：US10208023B2

公开(公告)日：2019-02-19

申请号：US14771628

申请日：2014-02-27

申请人： Mark G. DeGiacomo

发明人： Hassan Pajouhesh ,  Richard Holland ,  Lingyun Zhang ,  Hossein Pajouhesh ,  Jason Lamontagne ,  Brendan Whelan

IPC分类号： C07D403/06 ,  C07D403/04 ,  C07D403/12 ,  C07D233/76 ,  C07D401/04 ,  C07D235/14 ,  C07D401/12 ,  C07D241/08 ,  C07D241/44 ,  C07D265/30 ,  C07D207/08 ,  C07D207/16 ,  C07D211/58 ,  C07D211/60 ,  C07D295/18 ,  C07C237/08 ,  C07C237/18 ,  C07C237/20 ,  C07C237/24 ,  C07D207/09 ,  C07D295/185

摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (I)-(X) or Compounds (1)-(92) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotrophic lateral sclerosis, glaucoma, ischemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.