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公开(公告)号：US20170260130A1
公开(公告)日：2017-09-14
申请号：US15602089
申请日：2017-05-22
申请人： Mark G. DeGiacomo
发明人： Hassan Pajouhesh , Richard Holland , Lingyun Zhang , Hossein Pajouhesh , Jason Lamontagne , Brendan Whelan
IPC分类号： C07C237/06 , C07D207/16 , C07D211/60 , C07D235/14 , C07D401/04 , C07D403/04 , C07D403/06 , C07D413/04 , C07D205/04 , C07D401/12 , C07D413/06 , C07D241/08 , C07C237/04 , C07D231/14 , C07D265/30 , C07C237/22 , C07C237/24
CPC分类号： C07C237/06 , A61K31/401 , A61K31/454 , A61K31/5377 , C07C237/04 , C07C237/22 , C07C237/24 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D207/16 , C07D211/60 , C07D231/14 , C07D235/14 , C07D241/08 , C07D265/30 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D413/04 , C07D413/06
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.
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公开(公告)号：US20200017488A1
公开(公告)日：2020-01-16
申请号：US16579803
申请日：2019-09-23
申请人： Mark G. DeGiacomo
IPC分类号： C07D417/12 , C07D307/24 , C07D277/52 , C07C311/10 , C07C233/58 , C07D285/08 , C07D207/16 , C07D239/42 , C07D237/20 , C07C237/24 , C07C235/40 , C07C311/51
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (I)-(III) or Compounds (1)-(65) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotropic lateral sclerosis, glaucoma, ischaemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.
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公开(公告)号：US20180111894A1
公开(公告)日：2018-04-26
申请号：US15846198
申请日：2017-12-18
申请人： Mark G. DeGiacomo
发明人： Hassan Pajouhesh , Richard Holland , Lingyun Zhang , Hossein Pajouhesh , Jason Lamontagne , Brendan Whelan
IPC分类号： C07C237/06 , C07C237/22 , C07D265/30 , C07D231/14 , C07C237/04 , C07D241/08 , C07D413/06 , C07D401/12 , C07D205/04 , C07D413/04 , C07D403/06 , C07D403/04 , C07D401/04 , C07D235/14 , C07D211/60 , C07D207/16 , C07C237/24
CPC分类号： C07C237/06 , A61K31/401 , A61K31/454 , A61K31/5377 , C07C237/04 , C07C237/22 , C07C237/24 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D207/16 , C07D211/60 , C07D231/14 , C07D235/14 , C07D241/08 , C07D265/30 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D413/04 , C07D413/06
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) and in particular Formula (X), and Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.
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公开(公告)号：US10351514B2
公开(公告)日：2019-07-16
申请号：US15846198
申请日：2017-12-18
申请人： Mark G. DeGiacomo
发明人： Hassan Pajouhesh , Richard Holland , Lingyun Zhang , Hossein Pajouhesh , Jason Lamontagne , Brendan Whelan
IPC分类号： A61K31/401 , A61K31/454 , A61K31/5377 , C07C237/06 , C07C237/22 , C07C237/24 , C07D207/16 , C07D211/60 , C07D235/14 , C07D401/04 , C07D403/04 , C07D403/06 , C07D413/04 , C07D205/04 , C07D401/12 , C07D413/06 , C07C237/04 , C07D231/14 , C07D265/30 , C07D241/08
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) and in particular Formula (X), and Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.
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公开(公告)号：US09688615B2
公开(公告)日：2017-06-27
申请号：US14833601
申请日：2015-08-24
申请人： Mark G. DeGiacomo
发明人： Hassan Pajouhesh , Richard Holland , Lingyun Zhang , Hossein Pajouhesh , Jason Lamontagne , Brendan Whelan
IPC分类号： C07D207/16 , C07D205/04 , C07D265/30 , C07D231/14 , C07D211/60 , C07C237/04 , C07C237/06 , C07C237/22 , C07C237/24 , C07D235/14 , C07D401/04 , C07D403/04 , C07D403/06 , C07D413/04 , C07D401/12 , C07D413/06 , C07D241/08
CPC分类号： C07C237/06 , C07C237/04 , C07C237/22 , C07C237/24 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D207/16 , C07D211/60 , C07D231/14 , C07D235/14 , C07D241/08 , C07D265/30 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D413/04 , C07D413/06
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.
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公开(公告)号：US20170145003A1
公开(公告)日：2017-05-25
申请号：US15122085
申请日：2015-02-26
申请人： Mark G. DeGiacomo
IPC分类号： C07D417/12 , C07D207/16 , C07D277/52 , C07C311/51 , C07C235/40 , C07C311/10 , C07D237/20 , C07C237/24 , C07C233/58 , C07D307/24 , C07D285/08 , C07D239/42
CPC分类号： C07D417/12 , C07C233/58 , C07C233/66 , C07C235/40 , C07C237/24 , C07C311/04 , C07C311/10 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D237/20 , C07D239/42 , C07D277/52 , C07D285/08 , C07D307/24
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (1)-(11 1) or Compounds (1)-(65) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotropic lateral sclerosis, glaucoma, ischaemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.
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公开(公告)号：US11236078B2
公开(公告)日：2022-02-01
申请号：US16579803
申请日：2019-09-23
申请人： Mark G. DeGiacomo
IPC分类号： C07D417/12 , C07C311/51 , C07C235/40 , C07C237/24 , C07D237/20 , C07D239/42 , C07D207/16 , C07D285/08 , C07C311/04 , C07C233/66 , C07C233/58 , C07C311/10 , C07D277/52 , C07D307/24
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (I)-(III) or Compounds (1)-(65) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotropic lateral sclerosis, glaucoma, ischaemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.
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公开(公告)号：US10208023B2
公开(公告)日：2019-02-19
申请号：US14771628
申请日：2014-02-27
申请人： Mark G. DeGiacomo
发明人： Hassan Pajouhesh , Richard Holland , Lingyun Zhang , Hossein Pajouhesh , Jason Lamontagne , Brendan Whelan
IPC分类号： C07D403/06 , C07D403/04 , C07D403/12 , C07D233/76 , C07D401/04 , C07D235/14 , C07D401/12 , C07D241/08 , C07D241/44 , C07D265/30 , C07D207/08 , C07D207/16 , C07D211/58 , C07D211/60 , C07D295/18 , C07C237/08 , C07C237/18 , C07C237/20 , C07C237/24 , C07D207/09 , C07D295/185
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (I)-(X) or Compounds (1)-(92) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotrophic lateral sclerosis, glaucoma, ischemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.
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