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    Barrier catheter apparatus and method
    2.
    发明授权
    Barrier catheter apparatus and method 有权
    阻隔导管装置及方法

    公开(公告)号：US07875008B2

    公开(公告)日：2011-01-25

    申请号：US10924519

    申请日：2004-08-23

    申请人： Colin Chong ,  Keith Oberg ,  Paul Mounce ,  Peter C. Lord ,  William P. Van Antwerp

    发明人： Colin Chong ,  Keith Oberg ,  Paul Mounce ,  Peter C. Lord ,  William P. Van Antwerp

    IPC分类号： A61M5/00 ,  A61M25/18

    CPC分类号： A61M25/0068 ,  A61L29/085 ,  A61L29/103 ,  A61M5/14276 ,  A61M25/005 ,  A61M2025/0073 ,  A61M2025/0076

    摘要： A catheter for use in delivery or withdrawal of a formulation, wherein the catheter has an outer layer comprising a bio-compatible material and a barrier layer comprising a material that provides a more effective barrier than the outer layer against inward and outward diffusion of substances that may cause destabilization of the formulation. The catheter may include a flared distal end tip to aid in the release, during a bolus delivery or catheter flush, of any obstruction situated at the distal end tip of the catheter. The catheter may also include a slit valve at the distal end tip which has one or more and, preferably a plurality of slits that may be elastically extended to an open position by the expulsion of the formulation during an IIP pump stroke. During the interval between IIP pump strokes, the slits return to a closed position and hinder the inflow of body fluid into the distal end tip.

    摘要翻译： 一种用于递送或取出制剂的导管，其中所述导管具有包含生物相容性材料的外层和阻挡层，所述阻挡层包含提供比所述外层更有效的屏障的材料，以抵抗物质的向内和向外扩散 可能导致制剂不稳定。 导管可以包括扩张的远端尖端，以帮助在推送或导管冲洗期间释放位于导管的远端尖端处的任何阻塞物。 导管还可以包括在远端尖端处的狭缝阀，其具有一个或多个且优选多个狭缝，其可以在IIP泵冲程期间通过排出制剂而弹性地延伸到打开位置。 在IIP泵冲程间隔期间，狭缝返回到关闭位置并阻止体液流入远端尖端。

    Barrier catheter apparatus and method
    3.
    发明申请
    Barrier catheter apparatus and method 有权
    阻隔导管装置及方法

    公开(公告)号：US20050021001A1

    公开(公告)日：2005-01-27

    申请号：US10924519

    申请日：2004-08-23

    申请人： Colin Chong ,  Keith Oberg ,  Paul Mounce ,  Peter Lord ,  William Antwerp

    发明人： Colin Chong ,  Keith Oberg ,  Paul Mounce ,  Peter Lord ,  William Antwerp

    IPC分类号： A61L29/08 ,  A61L29/10 ,  A61M5/142 ,  A61M25/00 ,  A61M29/00

    CPC分类号： A61M25/0068 ,  A61L29/085 ,  A61L29/103 ,  A61M5/14276 ,  A61M25/005 ,  A61M2025/0073 ,  A61M2025/0076

    摘要： A catheter for use in delivery or withdrawal of a formulation, wherein the catheter has an outer layer comprising a bio-compatible material and a barrier layer comprising a material that provides a more effective barrier than the outer layer against inward and outward diffusion of substances that may cause destabilization of the formulation. The outer surface of the barrier layer contacts at least a portion of the inner surface of the outer layer. The catheter may include a flared distal end tip to aid in the release, during a bolus delivery or catheter flush, of any obstruction situated at the distal end tip of the catheter. The larger cross-sectional area at the flared distal end tip minimizes the chances that any obstruction that develops at the distal end tip will be sufficient to hinder the flow of the formulation within the lumen of the catheter. The catheter may also include a slit valve at the distal end tip which has one or more and, preferably a plurality of slits that may be elastically extended to an open position by the expulsion of the formulation during an IIP pump stroke. During the interval between IIP pump strokes, the slits return to a closed position and hinder the inflow of body fluid into the distal end tip.

    摘要翻译： 一种用于递送或取出制剂的导管，其中所述导管具有包含生物相容性材料的外层和阻挡层，所述阻挡层包含提供比所述外层更有效的屏障的材料，以抵抗物质的向内和向外扩散 可能导致制剂不稳定。 阻挡层的外表面与外层的内表面的至少一部分接触。 导管可以包括扩张的远端尖端，以帮助在推送或导管冲洗期间释放位于导管的远端尖端处的任何阻塞物。 在扩张的远端尖端处的较大的横截面面积使得在远端尖端处产生的任何阻塞物足以阻碍制剂在导管内腔内的流动的机会最小化。 导管还可以包括在远端尖端处的狭缝阀，其具有一个或多个且优选多个狭缝，其可以在IIP泵冲程期间通过排出制剂而弹性地延伸到打开位置。 在IIP泵冲程间隔期间，狭缝返回到关闭位置并阻止体液流入远端尖端。