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公开(公告)号：US07875008B2
公开(公告)日：2011-01-25
申请号：US10924519
申请日：2004-08-23
申请人： Colin Chong , Keith Oberg , Paul Mounce , Peter C. Lord , William P. Van Antwerp
发明人： Colin Chong , Keith Oberg , Paul Mounce , Peter C. Lord , William P. Van Antwerp
CPC分类号： A61M25/0068 , A61L29/085 , A61L29/103 , A61M5/14276 , A61M25/005 , A61M2025/0073 , A61M2025/0076
摘要： A catheter for use in delivery or withdrawal of a formulation, wherein the catheter has an outer layer comprising a bio-compatible material and a barrier layer comprising a material that provides a more effective barrier than the outer layer against inward and outward diffusion of substances that may cause destabilization of the formulation. The catheter may include a flared distal end tip to aid in the release, during a bolus delivery or catheter flush, of any obstruction situated at the distal end tip of the catheter. The catheter may also include a slit valve at the distal end tip which has one or more and, preferably a plurality of slits that may be elastically extended to an open position by the expulsion of the formulation during an IIP pump stroke. During the interval between IIP pump strokes, the slits return to a closed position and hinder the inflow of body fluid into the distal end tip.
摘要翻译： 一种用于递送或取出制剂的导管，其中所述导管具有包含生物相容性材料的外层和阻挡层，所述阻挡层包含提供比所述外层更有效的屏障的材料，以抵抗物质的向内和向外扩散 可能导致制剂不稳定。 导管可以包括扩张的远端尖端，以帮助在推送或导管冲洗期间释放位于导管的远端尖端处的任何阻塞物。 导管还可以包括在远端尖端处的狭缝阀，其具有一个或多个且优选多个狭缝，其可以在IIP泵冲程期间通过排出制剂而弹性地延伸到打开位置。 在IIP泵冲程间隔期间，狭缝返回到关闭位置并阻止体液流入远端尖端。
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公开(公告)号：US06280416B1
公开(公告)日：2001-08-28
申请号：US09253382
申请日：1999-02-19
IPC分类号： A61M3700
CPC分类号： A61M5/14276 , A61M5/141 , A61M5/1483 , A61M5/155 , Y10S128/12
摘要： A medication infusion pump includes a housing, a medication chamber defined within the housing, a medication delivery device in fluid communication with the medication chamber, a propellant chamber defined within the housing and adapted to apply a predetermined positive pressure to a medication in the medication chamber, and a non-ozone depleting, non-toxic propellant within the propellant chamber. The propellant preferably has a vapor pressure between about 11 psig and about 50 psig at 37° C.
摘要翻译： 药物输注泵包括壳体，限定在所述壳体内的药物室，与所述药物室流体连通的药物输送装置，限定在所述壳体内的推进剂室，并适于对所述药物室中的药物施加预定的正压力 ，以及推进剂室内的非消耗臭氧，无毒的推进剂。 推进剂优选在37℃下的蒸汽压在约11psig至约50psig之间。
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公开(公告)号：US5957890A
公开(公告)日：1999-09-28
申请号：US871830
申请日：1997-06-09
CPC分类号： A61M5/14276 , A61M2039/0226 , A61M39/26 , A61M5/141 , A61M5/165
摘要： A medication infusion pump is provided for substantially constant flow delivery of a selected medication from a medication chamber through a catheter to a patient. The medication infusion pump comprises a compact housing adapted for implantation into the body of a patient, wherein the housing defines a hollow interior forming a medication chamber. An inlet port on the housing permits transcutaneous access to and filling of the medication chamber within the housing. A flexible propellant reservoir occupies a portion of the medication chamber volume and is filled with a selected fluid propellant to apply a substantially constant pressure to the medication for medication delivery with substantially constant flow through an elongated capillary tube and the catheter for administration to the patient. The capillary tube is spooled within the housing at the perimeter thereof in association with an annular filter of large surface area to prevent impurities and particulate from entering and potentially clogging the capillary tube. The inlet port also includes a click plate for providing a positive feedback indication of proper registration between the inlet port and a refill needle for refilling the medication chamber.
摘要翻译： 提供了一种药物输注泵，用于将所选择的药物从药物腔通过导管到患者基本恒定的流量递送。 药物输注泵包括适于植入患者体内的紧凑的壳体，其中壳体限定形成药物室的中空内部。 壳体上的入口允许经皮进入和填充壳体内的药物室。 灵活的推进剂储存器占据药物腔体积的一部分，并且填充有选定的流体推进剂，以基本上恒定的流量通过细长的毛细管和用于向患者施用的导管向用于药物输送的药物施加基本上恒定的压力。 毛细管与其表面周围的环形过滤器一起在外壳内卷绕在壳体内，以防止杂质和微粒进入并潜在地堵塞毛细管。 入口还包括用于提供入口和再填充针之间正确对准的正反馈指示的点击板，用于重新填充药剂室。
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公开(公告)号：US5390671A
公开(公告)日：1995-02-21
申请号：US213101
申请日：1994-03-15
申请人： Peter C. Lord , William P. Van Antwerp , John J. Mastrototaro , Paul S. Cheney, II , Nannette M. Schnabel
发明人： Peter C. Lord , William P. Van Antwerp , John J. Mastrototaro , Paul S. Cheney, II , Nannette M. Schnabel
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1486 , A61B17/34 , A61M25/02 , G01N27/28 , G01N33/49 , A61B5/05 , A61B5/04
CPC分类号： A61B5/14865 , A61B17/3403 , A61B5/6849 , A61M25/02 , A61M2025/0206
摘要： An insertion set is provided for transcutaneous placement of a sensor such as a glucose sensor at a selected site within the body of a patient. The insertion set comprises a slotted insertion needle extending through a mounting base adapted for mounting onto the patient's skin. A flexible thin film sensor includes a proximal segment carried by the mounting base and defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment protruding from the mounting base with sensor electrodes for transcutaneous placement. The proximal and distal segments of the sensor are linearly offset or misaligned, with the distal segment fitted within the insertion needle for transcutaneous sensor placement with the needle as the mounting base is pressed onto the patient's skin. The insertion needle can then be withdrawn to leave the sensor distal segment at the selected insertion position with the sensor electrodes in contact with patient blood or other extracellular fluid.
摘要翻译： 提供插入组用于在病人体内的选定部位经皮放置诸如葡萄糖传感器之类的传感器。 插入组包括延伸穿过适于安装到患者皮肤上的安装基座的开槽插入针。 柔性薄膜传感器包括由安装基座承载的近端段，并且限定适于与合适的监视器电连接的导电触头，以及从安装基座突出的用于经皮放置的传感器电极的远端段。 传感器的近端段和远端段线性偏移或不对准，远端段装配在插入针内，用于经皮传感器放置，随着安装基座被压在病人的皮肤上。 然后可以将插入针抽出以将传感器远端段离开所选择的插入位置，同时传感器电极与患者血液或其它细胞外液接触。
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公开(公告)号：US5482473A
公开(公告)日：1996-01-09
申请号：US239960
申请日：1994-05-09
申请人： Peter C. Lord , William P. Van Antwerp , John J. Mastrototaro , Paul S. Cheney, II , Nannette M. Schnabel
发明人： Peter C. Lord , William P. Van Antwerp , John J. Mastrototaro , Paul S. Cheney, II , Nannette M. Schnabel
CPC分类号： H01R12/774 , H01R12/78 , H01R12/88 , A61B2562/227 , H05K2201/0133 , H05K3/325 , H05K3/361 , H05K3/365
摘要： A connector is provided for electrical connection to a flex circuit in a hermetically sealed manner. The flex circuit comprises thin film conductors encased between layers of insulative material, and including a proximal end with conductive contact pads exposed through one of the insulative layers. In a preferred form, the proximal ends of the two flex circuits are assembled in face-to-face relation and compressed by a clamp fixture against opposite side faces of a compressible terminal block. The terminal block is formed from a resilient insulative elastomer such as silicone rubber with embedded conductive strips having opposite edges exposed at the opposite side faces of the terminal block for electrically connecting aligned pairs of the contact pads on the two flex circuits. The exposed edges of the conductive strips are circumscribed by the insulative elastomer which engages the flex circuits with a footprint circumscribing the exposed contact pads, whereby the terminal block hermetically seals the interface between the conductive strips and the contact pads.
摘要翻译： 提供了一种用于以气密密封的方式电连接到柔性电路的连接器。 柔性电路包括封装在绝缘材料层之间的薄膜导体，并且包括具有通过绝缘层之一暴露的导电接触焊盘的近端。 在优选形式中，两个柔性电路的近端以面对面关系组装，并通过夹具固定器压靠在可压缩端子块的相对侧面上。 端子块由诸如硅橡胶的弹性绝缘弹性体形成，其中嵌入的导电带具有暴露在端子块的相对侧面处的相对边缘，用于电连接两个柔性电路上的对准的接触焊盘对。 导电条的暴露边缘由绝缘弹性体外接，该绝缘弹性体与柔性电路接合，其外接外露的接触焊盘，从而端子块气密地密封导电条和接触焊盘之间的界面。
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公开(公告)号：US5568806A
公开(公告)日：1996-10-29
申请号：US393159
申请日：1995-02-16
申请人： Paul S. Cheney, II , John J. Mastrototaro , Nannette M. Schnabel , Peter C. Lord , William P. Van Antwerp , Raymond D. Clark
发明人： Paul S. Cheney, II , John J. Mastrototaro , Nannette M. Schnabel , Peter C. Lord , William P. Van Antwerp , Raymond D. Clark
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1473 , A61B5/1486 , A61B17/34
CPC分类号： A61B5/4839 , A61B17/3403 , A61B5/14532 , A61B5/6849
摘要： An improved insertion set is provided for transcutaneous placement of a sensor such as a glucose sensor at a selected site within the body of a patient. The insertion set comprises an insertion needle extending through a mounting base adapted for mounting onto the patient's skin. A flexible thin film sensor includes a proximal segment carried by the mounting base and adapted for electrical connection to a suitable monitor or the like, and a distal segment protruding from the mounting base with sensor electrodes thereon for transcutaneous placement. The distal segment of the sensor and a distal segment of the insertion needle are positioned within a flexible cannula which extends from the mounting base, whereby placement of the mounting base onto the patient's skin causes the insertion needle to pierce the skin for transcutaneous placement of the cannula with the sensor therein. The insertion needle can then be withdrawn from the cannula and the mounting base to leave the sensor distal segment at the selected insertion position, with the sensor electrodes being exposed to patient blood or other extracellular fluid via a window formed in the cannula. The cannula is carried by the mounting base to insure alignment of the sensor electrodes with the cannula window.
摘要翻译： 提供了一种改进的插入组，用于在患者体内的选定位置处经皮放置诸如葡萄糖传感器的传感器。 插入组包括延伸穿过适于安装到患者皮肤上的安装基座的插入针。 柔性薄膜传感器包括由安装基座承载并适于与合适的监视器等电连接的近端段，以及从安装基座突出并具有用于经皮放置的传感器电极的远端段。 传感器的远端部分和插入针的远侧部分定位在从安装基部延伸的柔性套管内，由此将安装基座放置在患者皮肤上使得插入针刺穿皮肤以经皮放置 套管与传感器在其中。 然后可以将插入针从插管和安装基座中取出，以将传感器远端段离开所选择的插入位置，传感器电极通过形成在套管中的窗口暴露于患者血液或其它细胞外液体。 套管由安装基座承载，以确保传感器电极与套管窗口的对准。
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7.发明授权Valves, valved fluid transfer devices and ambulatory infusion devices including the same 有权阀，阀门流体输送装置和包括其的流动输液装置公开(公告)号：US08251960B2
公开(公告)日：2012-08-28
申请号：US12054009
申请日：2008-03-24
IPC分类号： A61M5/00
CPC分类号： A61M5/16881 , A61M5/14216 , A61M5/14276 , A61M5/16804 , A61M5/16813 , A61M39/22 , A61M39/24 , A61M2039/226 , A61M2205/0216 , A61M2205/0222 , A61M2205/18 , A61M2205/3317 , A61M2205/3331 , A61M2205/50 , A61M2205/52 , A61M2205/75 , A61M2205/8206 , F16K1/32
摘要： Valves, valved fluid transfer devices and ambulatory infusion devices including the same. The valves includes a valve element and a valve seat, and one of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion.
摘要翻译： 阀，阀门流体输送装置和包括其的流动输液装置。 阀包括阀元件和阀座，阀座和阀元件中的一个包括主体部分和密封部分，该密封部分比主要部分具有较小的粘性。
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8.发明申请公开(公告)号：US20080234638A1
公开(公告)日：2008-09-25
申请号：US12054251
申请日：2008-03-24
CPC分类号： A61M5/14216 , A61M5/14276 , A61M39/22 , A61M2205/0222 , A61M2207/00 , Y10T29/49826
摘要： Valves, valved fluid transfer devices and ambulatory infusion devices including the same.
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9.发明申请Valves, Valved Fluid Transfer Devices and Ambulatory Infusion Devices Including The Same 有权阀门，阀门流体输送装置和包括其的流动输液装置公开(公告)号：US20080234637A1
公开(公告)日：2008-09-25
申请号：US12054009
申请日：2008-03-24
IPC分类号： A61M5/00
CPC分类号： A61M5/16881 , A61M5/14216 , A61M5/14276 , A61M5/16804 , A61M5/16813 , A61M39/22 , A61M39/24 , A61M2039/226 , A61M2205/0216 , A61M2205/0222 , A61M2205/18 , A61M2205/3317 , A61M2205/3331 , A61M2205/50 , A61M2205/52 , A61M2205/75 , A61M2205/8206 , F16K1/32
摘要： Valves, valved fluid transfer devices and ambulatory infusion devices including the same.
摘要翻译： 阀，阀门流体输送装置和包括其的流动输液装置。
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公开(公告)号：US5665065A
公开(公告)日：1997-09-09
申请号：US452406
申请日：1995-05-26
申请人： Fredric C. Colman , Peter C. Lord
发明人： Fredric C. Colman , Peter C. Lord
CPC分类号： A61M5/14244 , A61M5/1723
摘要： A medication infusion device such as a programmable infusion pump includes data input regarding a selected patient parameter such as a current blood glucose reading. The infusion device includes a controller responsive to this data input to develop a medication delivery protocol which can be implemented automatically, recommended via a display for subsequent approval or rejection upon manipulation of control switches, or otherwise overridden in favor of a different medication delivery protocol.
摘要翻译： 诸如可编程输注泵的药物输注装置包括关于所选择的患者参数（例如当前血糖读数）的数据输入。 输注装置包括响应于该数据输入的控制器，用于开发可以自动实现的药物输送方案，通过显示器推荐，以便在控制开关操作时进行随后的批准或拒绝，或以其他方式重写而不同于不同的药物输送方案。
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