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公开(公告)号：US20050070974A1
公开(公告)日：2005-03-31
申请号：US10756176
申请日：2004-01-12
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
CPC分类号： A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36085
摘要： A method and apparatus for treating patients suffering from obesity or eating disorders by applying a predetermined stimulating signal to the patient's vagus nerve appropriate to alleviate the condition and by applying a neural conduction block to the vagus nerve at a blocking site with the neural conduction block selected to at least partially block nerve impulses on the vagus nerve at the blocking site.
摘要翻译： 一种用于通过将预定的刺激信号施加到患者的迷走神经以适当减轻病症并通过在所选择的神经传导阻滞的阻塞部位向迷走神经应用神经传导阻滞来治疗患有肥胖或进食障碍的患者的方法和装置 至少部分阻断阻塞部位的迷走神经上的神经冲动。
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2.发明申请公开(公告)号：US20080021512A1
公开(公告)日：2008-01-24
申请号：US11891770
申请日：2007-08-13
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译： 通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。 治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。 电刺激包括在刺激部位施加刺激信号。 在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。 选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。
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公开(公告)号：US20050038484A1
公开(公告)日：2005-02-17
申请号：US10881045
申请日：2004-06-30
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
摘要翻译： 用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。 将电信号施加到电极以调节迷走神经活性。 电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。 电信号的应用被停止。 重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。
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公开(公告)号：US20070135858A1
公开(公告)日：2007-06-14
申请号：US11656132
申请日：2007-01-22
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC分类号： A61N1/32
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
摘要翻译： 至少部分由至少部分由迷走神经活动支配至少一个患者的多个器官的患者的障碍中的至少一种通过包括将神经刺激器载体定位在患者的身体器官周围的方法来治疗， 器官由至少一个迷走神经树干支配。 电极设置在载体上并位于迷走神经干线处。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 该信号可以是阻塞或刺激信号。
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公开(公告)号：US20050131485A1
公开(公告)日：2005-06-16
申请号：US11040767
申请日：2005-01-21
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
CPC分类号： A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode at a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency in excess of 3,000 Hz for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus.
摘要翻译： 用于治疗至少部分由迷走神经活动表征的多种病症中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官上。 将电信号施加到电极以调节迷走神经活性。 电信号以超过3000Hz的频率施加，以产生神经传导阻滞至迷走神经，神经传导阻滞被选择以至少部分阻断迷走神经冲动。
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公开(公告)号：US20070142870A1
公开(公告)日：2007-06-21
申请号：US11656113
申请日：2007-01-22
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
摘要翻译： 至少部分由至少部分由迷走神经活动支配至少一个患者的多个器官的患者的障碍中的至少一种通过包括将神经刺激器载体定位在患者的身体器官周围的方法来治疗， 器官由至少一个迷走神经树干支配。 电极设置在载体上并位于迷走神经干线处。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 该信号可以是阻塞或刺激信号。
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公开(公告)号：US20070135857A1
公开(公告)日：2007-06-14
申请号：US11656122
申请日：2007-01-22
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC分类号： A61N1/32
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
摘要翻译： 至少部分由至少部分由迷走神经活动支配至少一个患者的多个器官的患者的障碍中的至少一种通过包括将神经刺激器载体定位在患者的身体器官周围的方法来治疗， 器官由至少一个迷走神经树干支配。 电极设置在载体上并位于迷走神经干线处。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 该信号可以是阻塞或刺激信号。
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公开(公告)号：US20070135846A1
公开(公告)日：2007-06-14
申请号：US11656123
申请日：2007-01-22
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC分类号： A61N1/32
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
摘要翻译： 至少部分由至少部分由迷走神经活动支配至少一个患者的多个器官的患者的障碍中的至少一种通过包括将神经刺激器载体定位在患者的身体器官周围的方法来治疗， 器官由至少一个迷走神经树干支配。 电极设置在载体上并位于迷走神经干线处。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 该信号可以是阻塞或刺激信号。
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公开(公告)号：US20050070970A1
公开(公告)日：2005-03-31
申请号：US10756166
申请日：2004-01-12
申请人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
CPC分类号： A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36064 , A61N1/36067
摘要： A method and apparatus for treating patients suffering from involuntary movement disorders (including epilepsy) by stimulating a selected cranial nerve of the patient with an electrical signal applied to induce a signal at brain by applying an electrical signal at the nerve to ameliorate the disorder and by applying a neural conduction block at the nerve selected to at least partially block nerve impulses on said nerve at a blocking site and reduce adverse effects of said signal on an organ.
摘要翻译： 一种用于通过用施加电信号刺激患者的选择的颅神经来治疗患有非自愿运动障碍（包括癫痫）的患者的方法和装置，以通过在神经处施加电信号来改善该疾病，并通过 在所选择的神经处应用神经传导阻滞，以在阻断部位至少部分地阻断所述神经上的神经冲动，并减少所述信号对器官的不良影响。
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公开(公告)号：US20050268923A1
公开(公告)日：2005-12-08
申请号：US11197271
申请日：2005-08-03
申请人： Mark Knudson , Katherine Tweden , Timothy Conrad
发明人： Mark Knudson , Katherine Tweden , Timothy Conrad
CPC分类号： A61F5/56 , A61F2/0059
摘要： A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.
摘要翻译： 患者的上呼吸道状况如打鼾和睡眠呼吸暂停通过选择在组织内选择用于有限迁移的颗粒材料并促进组织对该材料的纤维化反应来治疗。 将大量颗粒材料注入组织区域以使组织结构变硬。
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