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公开(公告)号：US5859210A
公开(公告)日：1999-01-12
申请号：US956195
申请日：1997-10-22
IPC分类号： C07C229/38 , C07C233/49 , C07C233/51 , C07C237/12 , C07C237/22 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , C07D207/44 , C07D207/452 , C07D207/46 , C07D213/71 , C07F5/02 , C07F5/04 , C07K5/02 , G01N33/543
CPC分类号： C07D207/452 , C07C229/38 , C07C233/49 , C07C233/51 , C07C237/12 , C07C237/22 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , C07D207/46 , C07D213/71 , C07F5/025 , C07K5/0207 , G01N33/54353
摘要： Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula IV and General Formula VI. In one embodiment, the reagent of General Formula IV may be used to form a complex with a boron compound, such as a complex shown in General Formula VI. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain of up to about 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide or disulfide moieties, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; group R.sub.3 is selected from one of an H, an alkyl, and a methylene or ethylene moiety with an electronegative substituent; and BAS and BAS* are biologically active species.
摘要翻译： 硼化合物络合剂，硼化合物络合物，以及合成这些试剂和络合物的方法。 这些试剂和络合物包括通式IV和通式VI所示的那些试剂和络合物。 在一个实施方案中，通式IV的试剂可用于与硼化合物如通式VI所示的络合物形成络合物。 通式IV通式VI在一个实施方案中，基团Z包含选自长度最多约6碳当量的饱和或不饱和链的间隔基，约6至18的无支链饱和或不饱和链 长度的碳当量与中间体酰胺或二硫化物部分中的至少一种和长度为约3至12碳当量的聚乙二醇链; 基团R3选自具有电负性取代基的H，烷基和亚甲基或亚乙基部分中的一个; BAS和BAS *是生物活性物种。
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公开(公告)号：US5744627A
公开(公告)日：1998-04-28
申请号：US691929
申请日：1996-08-05
IPC分类号： C07C229/38 , C07C233/49 , C07C233/51 , C07C237/12 , C07C237/22 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , C07D207/44 , C07D207/452 , C07D207/46 , C07D213/71 , C07F5/02 , C07F5/04 , C07K5/02 , G01N33/543
CPC分类号： C07D207/452 , C07C229/38 , C07C233/49 , C07C233/51 , C07C237/12 , C07C237/22 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , C07D207/46 , C07D213/71 , C07F5/025 , C07K5/0207 , G01N33/54353
摘要： Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula III, General Formula IV, and General Formula VI. In one embodiment, the reagents of General Formula III may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula IV. The reagent of General Formula IV may be used to form a complex with a boron compound, such as a complex shown in General Formula VI. ##STR1##
摘要翻译： 硼化合物络合剂，硼化合物络合物，以及合成这些试剂和络合物的方法。 这些试剂和络合物包括通式III，通式IV和通式VI所示的试剂和络合物。 在一个实施方案中，通式III的试剂可用于在与生物活性物质（BAS）缩合后生产通式IV的试剂。 通式IV的试剂可用于与硼化合物如通式VI所示的络合物形成络合物。 方程式IV
通用VI -
公开(公告)号：US5877297A
公开(公告)日：1999-03-02
申请号：US956196
申请日：1997-10-22
IPC分类号： C07C229/38 , C07C233/49 , C07C233/51 , C07C237/12 , C07C237/22 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , C07D207/44 , C07D207/452 , C07D207/46 , C07D213/71 , C07F5/02 , C07F5/04 , C07K5/02 , G01N33/543
CPC分类号： C07C233/51 , C07C229/38 , C07C233/49 , C07C237/12 , C07C237/22 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , C07D207/452 , C07D207/46 , C07D213/71 , C07F5/025 , C07K5/0207 , G01N33/54353
摘要： Boron compound completing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents. These reagents, including those shown as General Formula CII may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain up to about 0 to 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide and disulfide moieties, and a polyethylene glycol chain of from 3 to 12 carbon equivalents in length; group R.sub.2 is one of an alkyl and a methylene with an electronegative moiety; and BAS is a biologically active species.
摘要翻译： 硼化合物完成试剂，那些试剂的中间试剂和合成这些试剂的方法。 在本文所述的进一步反应后，可以使用这些试剂，包括通式CII所示的那些试剂与硼酸化合物如苯基硼酸或其衍生物复合。 通式CII在一个实施方案中，基团Z包括选自饱和或不饱和链长度至多约0至6个碳当量长度的间隔基，长度为约6至18个碳当量长度的无支链饱和或不饱和链， 中间体酰胺和二硫化物部分中的至少一个和长度为3至12个碳当量的聚乙二醇链; 基团R2是具有电负性部分的烷基和亚甲基之一; 而BAS是一种生物活性物种。
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公开(公告)号：US5777148A
公开(公告)日：1998-07-07
申请号：US691930
申请日：1996-08-05
IPC分类号： C07C229/38 , C07C233/49 , C07C233/51 , C07C237/12 , C07C237/22 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , C07D207/44 , C07D207/452 , C07D207/46 , C07D213/71 , C07F5/02 , C07F5/04 , C07K5/02 , G01N33/543 , C07C233/31
CPC分类号： C07C233/51 , C07C229/38 , C07C233/49 , C07C237/12 , C07C237/22 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , C07D207/452 , C07D207/46 , C07D213/71 , C07F5/025 , C07K5/0207 , G01N33/54353
摘要： Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula I and General Formula II may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. ##STR1##
摘要翻译： 公开硼化合物络合剂，这些试剂的中间试剂和合成这些试剂的方法。 在本文所述的进一步反应后，可以使用这些试剂，包括通式I和通式II所示的试剂，与硼酸化合物如苯基硼酸或其衍生物复合。 通用公式CI
通用CII
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