公开(公告)号：US20110060199A1

公开(公告)日：2011-03-10

申请号：US12884175

申请日：2010-09-16

申请人： Mark Ries Robinson ,  Mike Borrello ,  Richard P. Thompson ,  Stephen Vanslyke ,  Shonn Hendee ,  Greg Knipstein ,  Dan Welsh

发明人： Mark Ries Robinson ,  Mike Borrello ,  Richard P. Thompson ,  Stephen Vanslyke ,  Shonn Hendee ,  Greg Knipstein ,  Dan Welsh

IPC分类号： A61B5/157

CPC分类号： A61B5/14557 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150946 ,  A61B5/150961 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M1/1692 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3621 ,  A61M1/3639 ,  A61M1/3663 ,  A61M5/16831 ,  A61M2005/1404 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2230/201

摘要： The use of an optical or other measurement in a blood access system enables the determination of a fluid sample appropriate for measurement on a real time basis. This information can be used to control the blood access system and related measurement processes. The determination can be based on, for example, at least one of: optical density, optical scatter, analyte level, temperature, the absolute level of any of the preceding, the stability of any of the preceding, the rate of change of any of the preceding, or the value of any of the preceding relative to another determination. The determination can be made using, for example, at least one of: electrochemical sensor, ion specific electrode, capacitance measurement, impedance measurement, inductance measurement, conductivity measurement, optical measurement, and ultrasound measurement. The present invention relates to determination of the quality of a biological sample in which determination of an analyte concentration is to be made, and various methods and apparatuses related thereto. An evaluation of sample quality can be made by monitoring the temporal changes in the sample properties or characteristics as the biological sample is procured or measured. The methods and apparatuses described herein can be used to evaluate the temporal characteristics of a sample during sample acquisition and/or during determination of the sample analyte or parameter of interest. The sample quality assurance methods and apparatuses described herein can thus be used to ensure that a valid sample has been procured by or presented to an instrument or measurement system for analyte determination, thereby preventing the measurement and reporting of analyte values for a sample that is unstable or otherwise non-representative of the biological system from which the sample was obtained.

摘要翻译： 在血液存取系统中使用光学或其他测量能够实时地确定适于测量的流体样品。 该信息可用于控制血液存取系统和相关测量过程。 该测定可以基于例如光密度，光学散度，分析物水平，温度，前述任一项的绝对水平，前述任一项的稳定性，任何变化率 前一个或前一个相对于另一个确定的任何值的值。 可以使用例如电化学传感器，离子专用电极，电容测量，阻抗测量，电感测量，电导率测量，光学测量和超声测量中的至少一个来进行确定。 本发明涉及要进行测定分析物浓度的生物样品的质量的确定以及与其相关的各种方法和装置。 通过监测采购或测量生物样品的样品性质或特性的时间变化，可以对样品质量进行评估。 本文描述的方法和装置可以用于在样品获取期间和/或在样品分析物或感兴趣的参数的确定期间评估样品的时间特征。 因此，本文所述的样品质量保证方法和装置可以用于确保有效样品已经由用于分析物测定的仪器或测量系统获得或呈现给样品，从而防止对不稳定的样品的分析物值的测量和报告 或以其他方式代表获得样品的生物系统。

公开(公告)号：US20120065482A1

公开(公告)日：2012-03-15

申请号：US13193602

申请日：2011-07-29

申请人： Mark Ries Robinson ,  Mike Borrello ,  Richard P. Thompson ,  Stephen Vanslyke ,  Shonn Hendee ,  Dan Welsh ,  Steve Bernard ,  John O'Mahony ,  Dave McMahon ,  Victor Gerald Grafe ,  Dave Tobler ,  William R. Patterson ,  Donald W. Landry ,  James H. Macemon ,  Russell Abbink

发明人： Mark Ries Robinson ,  Mike Borrello ,  Richard P. Thompson ,  Stephen Vanslyke ,  Shonn Hendee ,  Dan Welsh ,  Steve Bernard ,  John O'Mahony ,  Dave McMahon ,  Victor Gerald Grafe ,  Dave Tobler ,  William R. Patterson ,  Donald W. Landry ,  James H. Macemon ,  Russell Abbink

IPC分类号： A61B5/145

CPC分类号： A61B5/150221 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61M2005/1588 ,  A61M2039/0009

摘要： The present invention provides methods and apparatuses related to measurement of analytes, including measurements of analytes in samples withdrawn from a patient.

摘要翻译： 本发明提供了与分析物的测量相关的方法和装置，包括从患者抽出的样品中的分析物的测量。

公开(公告)号：US20100168535A1

公开(公告)日：2010-07-01

申请号：US12714100

申请日：2010-02-26

申请人： Mark Ries Robinson ,  William R. Patterson ,  Richard P. Thompson ,  Shonn Hendee ,  James H. Macemon

发明人： Mark Ries Robinson ,  William R. Patterson ,  Richard P. Thompson ,  Shonn Hendee ,  James H. Macemon

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61M5/16831 ,  A61M2005/1404 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2230/201

摘要： The present invention relates to a blood analyte measurement system for the procurement of blood samples for measurement of blood properties such as analyte concentration or analyte presence. A blood access system can be coupled with a measurement system such as an electrochemical sensor, and can also be used with other measurement modalities. Embodiments of the present invention can facilitate accurate measurement of blood glucose by the clinician in a sterile manner. Embodiments of the present invention can also enable the calibration of the sensor at one or more calibration points. One desired analyte of measurement is glucose for the effective implementation of glycemic control protocols. Embodiments of the present invention can also be used for the measurement of other analytes such as arterial blood gases, lactate, hemoglobin, potassium and urea. Additionally, embodiments of the present invention can function effectively on a variety of blood access points and specifically enables glucose monitoring in an existing arterial line that is already in place for hemodynamic monitoring. The present invention does not consume a significant amount of blood. Some embodiments of the present invention can re-infuse the blood into the patient, which can facilitate operation of the system in a sterile manner.

摘要翻译： 本发明涉及一种用于血液分析物测量系统，用于采血用于测量血液特性如分析物浓度或分析物存在。 血液存取系统可以与诸如电化学传感器的测量系统耦合，并且还可以与其它测量模式一起使用。 本发明的实施方案可以促进临床医生以无菌方式精确测量血糖。 本发明的实施例还可以实现在一个或多个校准点处的传感器的校准。 一个期望的测量分析物是用于有效实施血糖控制方案的葡萄糖。 本发明的实施方案也可用于测量其它分析物，例如动脉血气，乳酸，血红蛋白，钾和尿素。 此外，本发明的实施例可以有效地在各种血液接入点上起作用，并且具体地实现已经存在于用于血液动力学监测的现有动脉管线中的葡萄糖监测。 本发明不消耗大量的血液。 本发明的一些实施例可以将血液重新注入患者体内，这可以以无菌的方式促进系统的操作。

公开(公告)号：US20100094114A1

公开(公告)日：2010-04-15

申请号：US12576303

申请日：2009-10-09

申请人： Mark Ries Robinson ,  Richard P. Thompson

发明人： Mark Ries Robinson ,  Richard P. Thompson

IPC分类号： A61B5/145

CPC分类号： A61B5/14532 ,  A61B2560/0223

摘要： The invention relates to an automated calibration procedure for analyte sensors such as glucose sensors. The system can provide a calibration point at zero analyte concentration as well as a second calibration point at a known analyte concentration or other pre-determined points. Although not restricted to two point calibration procedure, the system as described enables the system to create one or more calibration points. The use of multiple calibration points can allow the system to correct for both slope and bias drifts. The system also provides the opportunity to provide one or more validation samples. The present invention enables a multitude of options in both calibration and validation to ensure effective operation of the system.

摘要翻译： 本发明涉及用于诸如葡萄糖传感器的分析物传感器的自动校准程序。 该系统可以提供零分析物浓度的校准点以及在已知分析物浓度或其它预定点处的第二校准点。 尽管不限于两点校准程序，但所描述的系统使系统能够创建一个或多个校准点。 使用多个校准点可以允许系统校正斜率和偏置漂移。 该系统还提供了提供一个或多个验证样本的机会。 本发明使得校准和验证中的许多选项能够确保系统的有效操作。

公开(公告)号：US5240330A

公开(公告)日：1993-08-31

申请号：US966424

申请日：1992-10-26

申请人： Richard P. Thompson

发明人： Richard P. Thompson

IPC分类号： A45C3/10 ,  A45C9/00

CPC分类号： A45C3/10 ,  A45C9/00

摘要： A beach chair bundle includes first, second, third, and fourth panels of terry cloth. The second and third panels are joined by an elastic strip. The second panel is folded up on the first and fastened to it along side edges to form a pouch for a removable pillow. The third panel extends over the pillow pouch and down over the first panel to form an inverted envelope adapted to slip over a chair back. The fourth panel is folded up on the third and fastened to it along side edges to form a utility pocket. A flap cover and fastening strips hold the pocket closed. Tie loops connect the pillow pouch to the utility pocket, through the chair structure, to secure the beach chair bundle to the chair. A fastening strip across the lower exterior of the first panel, and a zipper half across the bottom exterior of the utility pocket provide for attachment of a towel and a bag respectively.

摘要翻译： 沙滩椅束包括毛圈布的第一，第二，第三和第四面板。 第二和第三面板通过弹性带连接。 第二个面板首先折叠起来并沿着侧边缘固定在其上，形成可移动枕头的小袋子。 第三面板在枕头袋上方延伸并且向下延伸到第一面板上以形成适于在椅子上滑动的倒置的信封。 第四个面板折叠在第三个面板上，并沿着侧边缘固定在其上，形成一个实用口袋。 翼片盖和紧固条使口袋闭合。 领带环将枕头袋连接到实用口袋，通过椅子结构，将沙滩椅束固定在椅子上。 穿过第一面板的下部外部的紧固带和穿过实用口袋的底部外部的拉链半部分分别用于附接毛巾和袋子。