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    METHODS AND APPARATUSES RELATED TO BLOOD ANALYTE MEASUREMENT SYSTEM
    1.
    发明申请
    METHODS AND APPARATUSES RELATED TO BLOOD ANALYTE MEASUREMENT SYSTEM 审中-公开
    与血液分析仪测量系统相关的方法和装置

    公开(公告)号：US20100168535A1

    公开(公告)日：2010-07-01

    申请号：US12714100

    申请日：2010-02-26

    申请人： Mark Ries Robinson ,  William R. Patterson ,  Richard P. Thompson ,  Shonn Hendee ,  James H. Macemon

    发明人： Mark Ries Robinson ,  William R. Patterson ,  Richard P. Thompson ,  Shonn Hendee ,  James H. Macemon

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14532 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61M5/16831 ,  A61M2005/1404 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2230/201

    摘要： The present invention relates to a blood analyte measurement system for the procurement of blood samples for measurement of blood properties such as analyte concentration or analyte presence. A blood access system can be coupled with a measurement system such as an electrochemical sensor, and can also be used with other measurement modalities. Embodiments of the present invention can facilitate accurate measurement of blood glucose by the clinician in a sterile manner. Embodiments of the present invention can also enable the calibration of the sensor at one or more calibration points. One desired analyte of measurement is glucose for the effective implementation of glycemic control protocols. Embodiments of the present invention can also be used for the measurement of other analytes such as arterial blood gases, lactate, hemoglobin, potassium and urea. Additionally, embodiments of the present invention can function effectively on a variety of blood access points and specifically enables glucose monitoring in an existing arterial line that is already in place for hemodynamic monitoring. The present invention does not consume a significant amount of blood. Some embodiments of the present invention can re-infuse the blood into the patient, which can facilitate operation of the system in a sterile manner.

    摘要翻译： 本发明涉及一种用于血液分析物测量系统，用于采血用于测量血液特性如分析物浓度或分析物存在。 血液存取系统可以与诸如电化学传感器的测量系统耦合，并且还可以与其它测量模式一起使用。 本发明的实施方案可以促进临床医生以无菌方式精确测量血糖。 本发明的实施例还可以实现在一个或多个校准点处的传感器的校准。 一个期望的测量分析物是用于有效实施血糖控制方案的葡萄糖。 本发明的实施方案也可用于测量其它分析物，例如动脉血气，乳酸，血红蛋白，钾和尿素。 此外，本发明的实施例可以有效地在各种血液接入点上起作用，并且具体地实现已经存在于用于血液动力学监测的现有动脉管线中的葡萄糖监测。 本发明不消耗大量的血液。 本发明的一些实施例可以将血液重新注入患者体内，这可以以无菌的方式促进系统的操作。

    HEMODYNAMIC MONITORING DURING AUTOMATED MEASUREMENT OF BLOOD CONSTITUENTS
    3.
    发明申请
    HEMODYNAMIC MONITORING DURING AUTOMATED MEASUREMENT OF BLOOD CONSTITUENTS 审中-公开
    血液自动测量期间的血液动力学监测

    公开(公告)号：US20100094113A1

    公开(公告)日：2010-04-15

    申请号：US12576121

    申请日：2009-10-08

    申请人： Mark Ries Robinson ,  Mike Borrello ,  William R. Patterson

    发明人： Mark Ries Robinson ,  Mike Borrello ,  William R. Patterson

    IPC分类号： A61B5/1473 ,  A61B5/02 ,  A61B5/021

    CPC分类号： A61B5/0215 ,  A61B5/14532 ,  A61B5/14546

    摘要： The present invention provides methods and apparatuses that can provide measurement of analytes such as glucose with a variety of sensors in connection with hemodynamic monitoring. Some embodiments of the present invention enable the use of a single arterial access site for automated blood glucose measurement as well as hemodynamic monitoring. Some embodiments of the present invention can reduce or eliminate nuisance hemodynamic alarms. Some embodiments of the present invention can provide hemodynamic monitoring during an automated analyte measurement process. An example apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with or integrated into the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system.

    摘要翻译： 本发明提供了可以提供诸如葡萄糖等分析物与血液动力学监测相结合的各种传感器的测量方法和装置。 本发明的一些实施例使得能够使用单个动脉进入部位进行自动血糖测量以及血液动力学监测。 本发明的一些实施例可以减少或消除麻烦的血液动力学警报。 本发明的一些实施方案可以在自动分析物测量过程中提供血液动力学监测。 根据本发明的示例性装置包括血液存取系统，其适于从身体去除血液并将至少一部分血液注入体内。 这样的装置还包括安装有或集成到血液存取系统中的分析物传感器，使得分析物传感器测量血液中已被血液存取系统从体内除去的分析物。

    Disposable cartridge for producing gas-enriched fluids
    4.
    发明授权
    Disposable cartridge for producing gas-enriched fluids 有权
    用于生产富含气体的流体的一次性筒

    公开(公告)号：US07820102B2

    公开(公告)日：2010-10-26

    申请号：US10402463

    申请日：2003-03-28

    申请人： Stephen E. Myrick ,  Gregory P. Watson ,  William R. Patterson ,  Paul J. Zalesky

    发明人： Stephen E. Myrick ,  Gregory P. Watson ,  William R. Patterson ,  Paul J. Zalesky

    IPC分类号： A61M1/00 ,  A61M37/00

    CPC分类号： A61M1/3621 ,  A61M1/32 ,  A61M1/3626 ,  A61M2202/0208 ,  A61M2202/0476 ,  B01F3/04758

    摘要： A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid under pressure to an atomizer. The atomizer delivers fluid droplets into a gas-pressurized atomization chamber to enrich the physiologic fluid with the gas. The gas-enriched physiologic fluid is delivered to a mixing chamber in the cartridge where the gas-enriched physiologic fluid is mixed with a bodily fluid, such as blood, to create a gas-enriched bodily fluid.

    摘要翻译： 装置产生气体富集的生理流体并将其与体液结合以产生富含气体的体液。 该装置可以采取一次性盒式的形式。 药筒可以包括用于将生理液体在压力下输送到雾化器的流体供应室。 雾化器将流体液滴输送到气体加压的雾化室中以与气体一起富集生理液体。 将气体富集的生理液体输送到药筒中的混合室，其中富含气体的生理液体与诸如血液的体液混合，以产生富含气体的体液。

    Apparatus and method for blood oxygenation
    5.
    发明授权
    Apparatus and method for blood oxygenation 有权

    公开(公告)号：US06387324B1

    公开(公告)日：2002-05-14

    申请号：US09409952

    申请日：1999-09-30

    申请人： William R. Patterson ,  Stephen E. Myrick ,  Vincent Divino, Jr. ,  Jeffrey L. Creech ,  Mark S. Buhr

    发明人： William R. Patterson ,  Stephen E. Myrick ,  Vincent Divino, Jr. ,  Jeffrey L. Creech ,  Mark S. Buhr

    IPC分类号： A61M114

    CPC分类号： A61M1/1698 ,  A61M1/3613 ,  A61M2202/0476 ,  B01F3/04758 ,  Y10S128/03 ,  Y10S261/28

    摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

    Method of blood oxygenation
    9.
    发明授权
    Method of blood oxygenation 失效
    血氧合法

    公开(公告)号：US06855291B2

    公开(公告)日：2005-02-15

    申请号：US10384301

    申请日：2003-03-07

    申请人： William R. Patterson ,  Stephen E. Myrick ,  Vincent Divino, Jr. ,  Jeffrey L. Creech ,  Mark S. Buhr

    发明人： William R. Patterson ,  Stephen E. Myrick ,  Vincent Divino, Jr. ,  Jeffrey L. Creech ,  Mark S. Buhr

    IPC分类号： A61M1/16 ,  A61M1/36 ,  A61M1/14 ,  A61M37/00

    CPC分类号： A61M1/1698 ,  A61M1/3613 ,  A61M2202/0476 ,  B01F3/04758 ,  Y10S128/03 ,  Y10S261/28

    摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membranes(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.

    摘要翻译： 提供了一种用于血氧的装置和方法。 该装置包括具有第一入口以容纳气体过饱和流体例如生理盐水的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。 联接到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到其中，以产生气体过饱和流体，其通过出口被去除。 去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。 或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成含氧血液，再次输送到患者或其他部位。