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    Long acting injectable formulations
    4.
    发明申请
    Long acting injectable formulations 有权
    长效注射制剂

    公开(公告)号：US20070042013A1

    公开(公告)日：2007-02-22

    申请号：US11207980

    申请日：2005-08-19

    申请人： Mark Soll ,  Peter Hanson ,  Krishan Kumar ,  Monica Tejwani-Motwani

    发明人： Mark Soll ,  Peter Hanson ,  Krishan Kumar ,  Monica Tejwani-Motwani

    IPC分类号： A01N43/04 ,  A01N25/00

    CPC分类号： A61K31/00 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K48/00

    摘要： The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

    摘要翻译： 本申请涉及用于对抗哺乳动物体内寄生虫和内寄生虫的长效注射剂（LAI）制剂。 特别地，本发明提供了包含皮下挥发性溶剂，生物学上可接受的聚合物，生物活性剂和任选的一种或多种抗外寄生物或抗内分泌上可接受的添加剂或赋形剂的LAI制剂。 令人惊奇的是，本发明的液体长效注射制剂通过具有长期稳定性能够解决与先前可注射制剂相关的问题，能够适应较小的针头直径并且实现控制哺乳动物中害虫的长效应。 本发明的独特配方还允许抵抗已经变得对大环内酯类抗生素具有抗性的外寄生物和内寄生虫。

    SYSTEM AND METHOD FOR MANAGING A MODEL-BASED DESIGN LIFECYCLE
    6.
    发明申请
    SYSTEM AND METHOD FOR MANAGING A MODEL-BASED DESIGN LIFECYCLE 审中-公开
    用于管理基于模型的设计生物的系统和方法

    公开(公告)号：US20100235809A1

    公开(公告)日：2010-09-16

    申请号：US12403295

    申请日：2009-03-12

    申请人： Manaswini Rath ,  Kevin Uker ,  Kumar Mahadevan ,  Krishan Kumar ,  Shobhit Shanker ,  Lavanya Mallikarjuna ,  Soumya Nandavarapu ,  Aneel Kumar Reddy ,  Harish Gurram

    发明人： Manaswini Rath ,  Kevin Uker ,  Kumar Mahadevan ,  Krishan Kumar ,  Shobhit Shanker ,  Lavanya Mallikarjuna ,  Soumya Nandavarapu ,  Aneel Kumar Reddy ,  Harish Gurram

    IPC分类号： G06F3/048 ,  G06F9/44

    CPC分类号： G06F8/20

    摘要： Methods and systems are provided for managing a model-based design lifecycle having a plurality of stages. The system comprises an input interface for receiving input from the user of the system, a display device, and a processor coupled to the input interface and the display device. The processor is configured to display a user interface on the display device, wherein the user interface comprises a plurality of controls that each corresponds to a different process associated with a stage of the model-based design lifecycle. Certain ones of the controls are configured to require the user to perform the corresponding processes in a required order and certain other ones of the controls are arranged to encourage the user to perform the corresponding operation in a preferred order. The processor is also configured to retrieve a software module for each selected control to implement the corresponding process.

    摘要翻译： 提供了用于管理具有多个阶段的基于模型的设计生命周期的方法和系统。 该系统包括用于从系统的用户接收输入的输入接口，显示设备和耦合到输入接口和显示设备的处理器。 处理器被配置为在显示设备上显示用户界面，其中用户界面包括多个控件，每个对应于与基于模型的设计生命周期的阶段相关联的不同过程。 控制器中的某些被配置为要求用户以所需的顺序执行相应的处理，并且安排某些其他控制器以鼓励用户以优选顺序执行相应的操作。 处理器还被配置为为每个选择的控制器检索软件模块以实现相应的过程。

    Dual functioning excipient for metal chelate contrast agents
    7.
    发明授权
    Dual functioning excipient for metal chelate contrast agents 失效
    金属螯合造影剂双功能赋形剂

    公开(公告)号：US07385041B2

    公开(公告)日：2008-06-10

    申请号：US10787526

    申请日：2004-02-26

    申请人： C. Allen Chang ,  Krishan Kumar ,  Michael F. Tweedle

    发明人： C. Allen Chang ,  Krishan Kumar ,  Michael F. Tweedle

    IPC分类号： C07F13/00

    CPC分类号： A61K49/06 ,  A61K49/0002 ,  A61K49/04 ,  A61K51/0482 ,  A61K2123/00

    摘要： A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient, Xm[X′(L′)]n, which is the calcium or zinc salt of the calcium or zinc complex of an organic ligand, enhances safety in that it is able to scavenge both free metal ions and free organic ligand.

    摘要翻译： 公开了一种用于金属螯合造影剂的新型双功能赋形剂。 本发明的赋形剂<？in-line-formula description =“In-line Formulas”end =“lead”？> X＆lt; X'（L'）] n ，<？in-line-formula description =“在线公式”end =“tail”？>它是有机配体的钙或锌络合物的钙或锌盐，增强了安全性，因为它能够 清除游离金属离子和游离有机配体。

    Process for the preparation of p-toluic acid by liquid phase oxidation of p-xylene in water
    8.
    发明申请
    Process for the preparation of p-toluic acid by liquid phase oxidation of p-xylene in water 有权
    通过水中对二甲苯的液相氧化制备对甲苯甲酸的方法

    公开(公告)号：US20060247464A1

    公开(公告)日：2006-11-02

    申请号：US11378055

    申请日：2006-03-17

    申请人： Mahendra Saxena ,  Ashok Gupta ,  Satish Sharma ,  Dinesh Bangwal ,  Krishan Kumar

    发明人： Mahendra Saxena ,  Ashok Gupta ,  Satish Sharma ,  Dinesh Bangwal ,  Krishan Kumar

    IPC分类号： C07C51/16 ,  C07C51/255

    CPC分类号： C07C51/265 ,  Y02P20/584 ,  C07C63/04

    摘要： The present invention provides a process for the preparation of p-toluic acid by liquid phase oxidation of p-xylene using oxygen or air as oxidant in the presence of p-toluic acid, water as solvent and cobalt salt or its combinations with salts of Ce, Mn as catalyst. Oxidation is carried out at 130-190° C. and pressure sufficient to keep water in liquid state. Oxidation step is followed by filteration to obtain p-toluic acid as major product. Unreacted p-xylene is recovered and recycled and the catalyst is recovered from aqueous phase and is recycled.

    摘要翻译： 本发明提供了一种通过在对甲苯甲酸，水作为溶剂和钴盐或其与Ce的盐的存在下，使用氧或空气作为氧化剂的对二甲苯的液相氧化制备对甲苯甲酸的方法 ，Mn为催化剂。 在130-190℃下进行氧化和足以使水保持液态的压力。 氧化步骤之后进行过滤，得到对甲苯甲酸为主要产物。 回收未反应的对二甲苯并回收，并从水相回收催化剂并回收。

    Long acting injectable formulations
    9.
    发明授权
    Long acting injectable formulations 有权
    长效注射制剂

    公开(公告)号：US08362086B2

    公开(公告)日：2013-01-29

    申请号：US11207980

    申请日：2005-08-19

    申请人： Mark D. Soll ,  Peter Hanson ,  Krishan Kumar ,  Monica Tejwani-Motwani

    发明人： Mark D. Soll ,  Peter Hanson ,  Krishan Kumar ,  Monica Tejwani-Motwani

    IPC分类号： A61K31/63 ,  A61K31/7048

    CPC分类号： A61K31/00 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K48/00

    摘要： The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

    摘要翻译： 本申请涉及用于对抗哺乳动物体内寄生虫和内寄生虫的长效注射剂（LAI）制剂。 特别地，本发明提供了包含皮下挥发性溶剂，生物学上可接受的聚合物，生物活性剂和任选的一种或多种抗外寄生物或抗内分泌上可接受的添加剂或赋形剂的LAI制剂。 令人惊奇的是，本发明的液体长效注射制剂通过具有长期稳定性能够解决与先前可注射制剂相关的问题，能够适应较小的针头直径并且实现控制哺乳动物中害虫的长效应。 本发明的独特配方还允许抵抗已经变得对大环内酯类抗生素具有抗性的外寄生物和内寄生虫。