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![3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof](/abs-image/US/2012/09/18/US08268853B2/abs.jpg.150x150.jpg)
1.发明授权3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof 有权3,9-二氮杂螺[5,5]十一烷酰胺和脲及其使用方法公开(公告)号：US08268853B2
公开(公告)日：2012-09-18
申请号：US12823969
申请日：2010-06-25
IPC分类号： A61K31/438 , C07D221/20
CPC分类号： C07D471/10 , A61K31/4375
摘要： Compounds of formula (I) are useful in treating conditions or disorders ameliorated by α4β2 positive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
摘要翻译： 式（I）化合物可用于治疗由α4和bgr2阳性变构调节剂改善的病症或障碍。 还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法及其制备方法。
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![3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF](/abs-image/US/2010/12/30/US20100331353A1/abs.jpg.150x150.jpg)
2.发明申请3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF 有权3,9-DIAZASPIRO [5,5] UNDECANE AMIDES AND UREAS AND METHODS OF THEREOF公开(公告)号：US20100331353A1
公开(公告)日：2010-12-30
申请号：US12823969
申请日：2010-06-25
IPC分类号： A61K31/4375 , C07D471/10 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/34 , A61P25/30 , A61P25/24 , A61P29/00 , A61P25/04
CPC分类号： C07D471/10 , A61K31/4375
摘要： Compounds of formula (I) are useful in treating conditions or disorders ameliorated by α4β2 postive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
摘要翻译： 式（I）化合物可用于治疗由α4和bgr2两种后变构调节剂改善的病症或障碍。 还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法及其制备方法。
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公开(公告)号：US20100216748A1
公开(公告)日：2010-08-26
申请号：US12775735
申请日：2010-05-07
申请人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
发明人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号： A61K31/655 , C07D207/34 , A61K31/402 , A61P25/28 , A61P29/00 , A61P25/34 , A61P17/02 , A61P19/02 , A61P37/06 , A61P1/04 , A61P25/24 , A61P25/18 , C07D405/10 , A61K31/4025 , C07D409/10 , C07D401/10 , A61K31/4439 , C07D413/10 , A61K31/5377 , C07D403/12 , A61K31/454 , C12Q1/02
CPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US07741364B2
公开(公告)日：2010-06-22
申请号：US11769395
申请日：2007-06-27
申请人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
发明人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号： A01N43/36
CPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US08796297B2
公开(公告)日：2014-08-05
申请号：US12828104
申请日：2010-06-30
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/505 , A61K31/506 , A61K31/551 , C07D239/48 , C07D403/04 , C07D403/12 , C07D471/04 , C07D471/10 , C07D487/04
摘要： Compounds of the formula wherein R1 and R2 are as disclosed herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor full or partial agonists. Also disclosed are pharmaceutical compositions, methods for using such compounds and compositions, and processes for preparing the compounds.
摘要翻译： 下式的化合物其中R1和R2如本文所公开的，可用于治疗由组胺-3受体全部或部分激动剂预防或改善的病症或病症。 还公开了药物组合物，使用这些化合物和组合物的方法以及制备化合物的方法。
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公开(公告)号：US08580968B2
公开(公告)日：2013-11-12
申请号：US13410206
申请日：2012-03-01
申请人： Lawrence A. Black , Marlon D. Cowart , Gregory A. Gfesser , Brian D. Wakefield , Robert J. Altenbach , Huaqing Liu , Chen Zhao , Gin C. Hsieh
发明人： Lawrence A. Black , Marlon D. Cowart , Gregory A. Gfesser , Brian D. Wakefield , Robert J. Altenbach , Huaqing Liu , Chen Zhao , Gin C. Hsieh
IPC分类号： A61K31/454 , A61K31/4545 , A61K31/428 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , C07D413/04 , C07D417/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法及其制备方法。
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公开(公告)号：US20120245163A1
公开(公告)日：2012-09-27
申请号：US13426732
申请日：2012-03-22
申请人： Arthur Gomtsyan , Jerome F. Daanen , Gregory A. Gfesser , Michael E. Kort , Chih-Hung Lee , Heath A. McDonald , Pamela S. Puttfarcken , Eric A. Voight , Philip R. Kym
发明人： Arthur Gomtsyan , Jerome F. Daanen , Gregory A. Gfesser , Michael E. Kort , Chih-Hung Lee , Heath A. McDonald , Pamela S. Puttfarcken , Eric A. Voight , Philip R. Kym
IPC分类号： A61K31/17 , C07D265/36 , A61K31/538 , C07D215/38 , A61K31/192 , C07D217/02 , A61K31/472 , C07D231/56 , A61K31/416 , A61P25/00 , C07C275/32 , A61K31/4704
CPC分类号： C07C275/32 , C07C2601/08 , C07C2602/08 , C07D209/08 , C07D215/38 , C07D217/02 , C07D231/56 , C07D239/80 , C07D263/48 , C07D265/36 , C07D401/04 , C07D413/12 , C07D417/12
摘要： Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, wherein X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）化合物或其药学上可接受的盐，溶剂化物或其组合，其中X1，X2，X3，X4，J，K，L，X5，X6，Rb，G2和m在本说明书中定义 。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20110098285A1
公开(公告)日：2011-04-28
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： A61K31/40 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506 , A61K31/5355 , A61K31/541 , A61K31/4709 , A61K31/501 , A61P25/28 , A61P11/06 , A61P25/00 , A61P25/16 , A61P3/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/30 , A61P3/10 , A61P3/04
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US07538138B2
公开(公告)日：2009-05-26
申请号：US11102415
申请日：2005-04-08
IPC分类号： C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , A61K31/343 , A61K31/44 , A61K31/47 , A61P25/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D307/79 , C07D307/81 , C07D333/54 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/04 , C07D491/08 , C07D491/10
摘要： Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.
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公开(公告)号：US09063126B2
公开(公告)日：2015-06-23
申请号：US12568085
申请日：2009-09-28
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/439 , C07D471/08 , G01N33/50 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/68
CPC分类号： G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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