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公开(公告)号：US5643563A
公开(公告)日：1997-07-01
申请号：US426036
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Y. Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Y. Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C12N15/73 , C07K14/53 , A61K38/00 , Y10S930/14 , Y10S930/145
摘要： New forms of CSF-1 are provided which relate to N-terminal truncations. Specifically, N-.gradient.3 terminal truncations of the short form of CSF-1 have been found to be particularly advantageous. These forms may have a C-terminal truncation at a variety of different amino acids beyond position 150.
摘要翻译： 提供了与N末端截短有关的新形式的CSF-1。 具体地说，已经发现短-CSF-1的N-NABLA 3末端截短是特别有利的。 这些形式在位置150以外的各种不同氨基酸处可能具有C-末端截短。
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公开(公告)号：US5573930A
公开(公告)日：1996-11-12
申请号：US999298
申请日：1992-12-28
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Y. Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Y. Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C12N15/73 , C07K14/53 , A61K38/00 , Y10S930/14 , Y10S930/145
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子，是可用于克服化疗诱导的免疫抑制或由其他原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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3.发明授权N.gradient.2-CSF-1(long form) and carboxy truncated fragments thereof 失效N NABLA 2-CSF-1（长形式）及其羧基截短的片段
公开(公告)号：US06117422A
公开(公告)日：2000-09-12
申请号：US425876
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C07K14/53 , C12N15/73 , A61K38/00 , Y10S930/14
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子。 是用于克服化疗诱导的免疫抑制或由其它原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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4.发明授权DNA encoding N- and C- terminally truncated colony stimulating factor-1 variants 失效编码N-和C-末端截短的集落刺激因子-1变体的DNA
公开(公告)号：US5681719A
公开(公告)日：1997-10-28
申请号：US401013
申请日：1995-03-08
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C12N15/73 , C07K14/53 , A61K38/00 , Y10S930/14 , Y10S930/145
摘要： DNA for new forms of CSF-1 are provided which relate to N-terminal and C-terminal truncations. Specifically, N-.gradient.3 terminal truncations of the short and long forms of CSF-1 have been found to be particularly advantageous. These forms may have a C-terminal truncation at a variety of different amino acids beyond position 149.
摘要翻译： 提供了关于N末端和C末端截短的新形式的CSF-1的DNA。 具体地说，发现短和长形式的CSF-1的N-NABLA 3末端截短是特别有利的。 这些形式可能在超过149位的多种不同氨基酸处具有C末端截短。
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5.发明授权Point mutants of N.gradient.2 CSF-1 and carboxy truncated fragments thereof 失效N NABLA 2 CSF-1的点突变体及其羧基截短的片段
公开(公告)号：US6156300A
公开(公告)日：2000-12-05
申请号：US426571
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子。 是用于克服化疗诱导的免疫抑制或由其它原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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公开(公告)号：US5672343A
公开(公告)日：1997-09-30
申请号：US426279
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C12N15/73 , C07K14/53 , A61K38/00 , Y10S930/14 , Y10S930/145
摘要： New forms of CSF-1 are provided which relate to N-terminal truncations. Specifically, N-.gradient.3 terminal truncations of the long form of CSF-1 have been found to be particularly advantageous. These forms may have a C-terminal truncation at a variety of different amino acids beyond position 150.
摘要翻译： 提供了与N末端截短有关的新形式的CSF-1。 具体地说，发现长形式的CSF-1的N-NABLA 3末端截短是特别有利的。 这些形式在位置150以外的各种不同氨基酸处可能具有C-末端截短。
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7.发明授权N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof 失效N NABLA 2 CSF-1（短型）及其羧基截短的片段
公开(公告)号：US6103224A
公开(公告)日：2000-08-15
申请号：US426570
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C07K14/53 , C12N15/73 , A61K38/00 , Y10S930/14
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子。 是用于克服化疗诱导的免疫抑制或由其它原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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8.发明授权DNA encoding N∇2 CSF-1 (short form) and carboxy truncated fragment thereof 失效编码N2CSF-1（短型）的DNA及其羧基截短的片段公开(公告)号：US06204020B1
公开(公告)日：2001-03-20
申请号：US08401632
申请日：1995-03-09
申请人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
IPC分类号： C12N121
CPC分类号： C12N15/73 , A61K38/00 , C07K14/53 , Y10S930/14 , Y10S930/145
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both “long” and “short” forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子，是一种可用于克服化疗引起的免疫抑制或由其他原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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9.发明授权
公开(公告)号：US6146851A
公开(公告)日：2000-11-14
申请号：US426243
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C07K14/53 , C12N15/73 , A61K38/00 , Y10S930/14
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子，是可用于克服化疗诱导的免疫抑制或由其他原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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10.发明授权Commodity Futures Index and methods and systems of trading in futures contracts that minimize turnover and transactions costs 有权商品期货指数及期货合约交易方式及制度，以最小化营业额及交易成本公开(公告)号：US08447694B2
公开(公告)日：2013-05-21
申请号：US12613356
申请日：2009-11-05
IPC分类号： G06Q40/00
摘要： This invention relates to methods and systems for reducing transaction costs and minimizes turnover in the trading of futures contracts. The invention further describes an algorithm whose output is a unique method of investing in futures contracts that reduces the rate of turnover, and thus the cost of trading, of certain common trading strategies. The primary application of this method is to a class of strategies referred to as indexing strategies that incorporate a dynamic asset allocation approach using futures contracts.
摘要翻译： 本发明涉及降低交易成本的方法和系统，并最小化期货合约交易的营业额。 本发明还描述了一种算法，其输出是投资期货合约的独特方法，其降低某些常见交易策略的周转率，从而降低交易成本。 这种方法的主要应用是一类被称为索引策略的策略，其中包含使用期货合约的动态资产分配方法。
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