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公开(公告)号：US5643563A
公开(公告)日：1997-07-01
申请号：US426036
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Y. Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Y. Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C12N15/73 , C07K14/53 , A61K38/00 , Y10S930/14 , Y10S930/145
摘要： New forms of CSF-1 are provided which relate to N-terminal truncations. Specifically, N-.gradient.3 terminal truncations of the short form of CSF-1 have been found to be particularly advantageous. These forms may have a C-terminal truncation at a variety of different amino acids beyond position 150.
摘要翻译： 提供了与N末端截短有关的新形式的CSF-1。 具体地说，已经发现短-CSF-1的N-NABLA 3末端截短是特别有利的。 这些形式在位置150以外的各种不同氨基酸处可能具有C-末端截短。
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公开(公告)号：US5573930A
公开(公告)日：1996-11-12
申请号：US999298
申请日：1992-12-28
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Y. Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Y. Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C12N15/73 , C07K14/53 , A61K38/00 , Y10S930/14 , Y10S930/145
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子，是可用于克服化疗诱导的免疫抑制或由其他原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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3.发明授权N.gradient.2-CSF-1(long form) and carboxy truncated fragments thereof 失效N NABLA 2-CSF-1（长形式）及其羧基截短的片段
公开(公告)号：US06117422A
公开(公告)日：2000-09-12
申请号：US425876
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C07K14/53 , C12N15/73 , A61K38/00 , Y10S930/14
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子。 是用于克服化疗诱导的免疫抑制或由其它原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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4.发明授权DNA encoding N- and C- terminally truncated colony stimulating factor-1 variants 失效编码N-和C-末端截短的集落刺激因子-1变体的DNA
公开(公告)号：US5681719A
公开(公告)日：1997-10-28
申请号：US401013
申请日：1995-03-08
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C12N15/73 , C07K14/53 , A61K38/00 , Y10S930/14 , Y10S930/145
摘要： DNA for new forms of CSF-1 are provided which relate to N-terminal and C-terminal truncations. Specifically, N-.gradient.3 terminal truncations of the short and long forms of CSF-1 have been found to be particularly advantageous. These forms may have a C-terminal truncation at a variety of different amino acids beyond position 149.
摘要翻译： 提供了关于N末端和C末端截短的新形式的CSF-1的DNA。 具体地说，发现短和长形式的CSF-1的N-NABLA 3末端截短是特别有利的。 这些形式可能在超过149位的多种不同氨基酸处具有C末端截短。
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5.发明授权Point mutants of N.gradient.2 CSF-1 and carboxy truncated fragments thereof 失效N NABLA 2 CSF-1的点突变体及其羧基截短的片段
公开(公告)号：US6156300A
公开(公告)日：2000-12-05
申请号：US426571
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子。 是用于克服化疗诱导的免疫抑制或由其它原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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公开(公告)号：US5672343A
公开(公告)日：1997-09-30
申请号：US426279
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C12N15/73 , C07K14/53 , A61K38/00 , Y10S930/14 , Y10S930/145
摘要： New forms of CSF-1 are provided which relate to N-terminal truncations. Specifically, N-.gradient.3 terminal truncations of the long form of CSF-1 have been found to be particularly advantageous. These forms may have a C-terminal truncation at a variety of different amino acids beyond position 150.
摘要翻译： 提供了与N末端截短有关的新形式的CSF-1。 具体地说，发现长形式的CSF-1的N-NABLA 3末端截短是特别有利的。 这些形式在位置150以外的各种不同氨基酸处可能具有C-末端截短。
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7.发明授权N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof 失效N NABLA 2 CSF-1（短型）及其羧基截短的片段
公开(公告)号：US6103224A
公开(公告)日：2000-08-15
申请号：US426570
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C07K14/53 , C12N15/73 , A61K38/00 , Y10S930/14
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子。 是用于克服化疗诱导的免疫抑制或由其它原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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8.发明授权DNA encoding N∇2 CSF-1 (short form) and carboxy truncated fragment thereof 失效编码N2CSF-1（短型）的DNA及其羧基截短的片段公开(公告)号：US06204020B1
公开(公告)日：2001-03-20
申请号：US08401632
申请日：1995-03-09
申请人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
IPC分类号： C12N121
CPC分类号： C12N15/73 , A61K38/00 , C07K14/53 , Y10S930/14 , Y10S930/145
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both “long” and “short” forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子，是一种可用于克服化疗引起的免疫抑制或由其他原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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9.发明授权
公开(公告)号：US6146851A
公开(公告)日：2000-11-14
申请号：US426243
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C07K14/53 , C12N15/73 , A61K38/00 , Y10S930/14
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子，是可用于克服化疗诱导的免疫抑制或由其他原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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公开(公告)号：US5736340A
公开(公告)日：1998-04-07
申请号：US473791
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K38/36 , A61K39/395 , A61K49/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P37/00 , C07K1/18 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/574
CPC分类号： C07K14/70546 , C07K14/705 , A61K38/00 , C07K2319/00 , Y10S436/813
摘要： A purified glycoprotein complex of over 1200 kD apparent native molecular weight having a sedimentation value of approximately 25S and having the ability to selectively bind human Mac-2 or interfere with PHA activation of lymphocytes, DNA sequences that encode the protein, and expression systems for expressing it, thus providing for reagents that are useful for treating or diagnosing diseases, including cancer, infectious disease, and diseases of the immune system, and for monitoring the concentration of the glycoprotein in human milk.
摘要翻译： 具有超过1200kD表观天然分子量的纯化糖蛋白复合物，其沉降值为约25S，并且具有选择性结合人Mac-2或干扰淋巴细胞的PHA活化的能力，编码蛋白质的DNA序列和用于表达的表达系统 从而提供可用于治疗或诊断疾病（包括癌症，感染性疾病和免疫系统疾病）的试剂，并且用于监测人乳中糖蛋白的浓度。
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