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公开(公告)号：US20070093441A1
公开(公告)日：2007-04-26
申请号：US11499659
申请日：2006-08-07
申请人： Martin Bachmann , Gary Jennings , Ivo Sonderegger
发明人： Martin Bachmann , Gary Jennings , Ivo Sonderegger
CPC分类号： A61K39/0007 , A61K38/00 , A61K38/162 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/646 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2730/10142 , C12N2795/18122 , C12N2810/852
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇的组合物，特别是包含IL-5，IL-13或嗜酸细胞活化趋化因子的蛋白质或肽的阵列。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一种IL-5，IL-13和/或嗜酸性粒细胞趋化因子的蛋白质或肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用嗜酸性成分治疗过敏性疾病的疫苗和作为药物以预防或治愈嗜酸性成分的过敏性疾病并有效诱导免疫应答，特别是抗体应答的疫苗。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号：US07094409B2
公开(公告)日：2006-08-22
申请号：US10289454
申请日：2002-11-07
申请人： Martin Bachmann , Gary Jennings , Ivo Sonderegger
发明人： Martin Bachmann , Gary Jennings , Ivo Sonderegger
IPC分类号： A61K39/385 , C12N7/00 , C07K17/00
CPC分类号： A61K39/0007 , A61K38/00 , A61K38/162 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/646 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2730/10142 , C12N2795/18122 , C12N2810/852
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
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公开(公告)号：US20090155302A1
公开(公告)日：2009-06-18
申请号：US12201731
申请日：2008-08-29
CPC分类号： A61K39/0007 , A61K38/00 , A61K38/162 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/646 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2730/10142 , C12N2795/18122 , C12N2810/852
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇的组合物，特别是包含IL-5，IL-13或嗜酸细胞活化趋化因子的蛋白质或肽的阵列。 更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种IL-5，IL-13和/或嗜酸性粒细胞趋化因子的蛋白质或肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于用嗜酸性成分治疗过敏性疾病的疫苗和作为药物以预防或治愈嗜酸性成分的过敏性疾病并有效诱导免疫应答，特别是抗体应答的疫苗。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号：US20130244940A1
公开(公告)日：2013-09-19
申请号：US13989174
申请日：2011-11-25
申请人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
发明人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
IPC分类号： C07K14/00
CPC分类号： A61K47/64 , A61K38/00 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
摘要： New designed repeat proteins with binding specificity for serum albumin are described, as well as nucleic acids encoding such serum albumin binding proteins, pharmaceutical compositions comprising such proteins, the use of such proteins to modify the pharmacokinetics of therapeutic relevant polypeptides and the use of such proteins in the treatment of diseases. The repeat proteins of the invention have a substantially increased half-life in plasma compared to proteins not binding serum albumin.
摘要翻译： 描述了对血清白蛋白具有结合特异性的新设计的重复蛋白质，以及编码这种血清白蛋白结合蛋白的核酸，包含这种蛋白质的药物组合物，使用这些蛋白质来改变治疗性相关多肽的药代动力学和使用这种蛋白质 在治疗疾病。 与不结合血清白蛋白的蛋白质相比，本发明的重复蛋白质具有显着增加的血浆半衰期。
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公开(公告)号：US09284361B2
公开(公告)日：2016-03-15
申请号：US13989174
申请日：2011-11-25
申请人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
发明人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
CPC分类号： A61K47/64 , A61K38/00 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
摘要： New designed repeat proteins with binding specificity for serum albumin are described, as well as nucleic acids encoding such serum albumin binding proteins, pharmaceutical compositions comprising such proteins, the use of such proteins to modify the pharmacokinetics of therapeutic relevant polypeptides and the use of such proteins in the treatment of diseases. The repeat proteins of the invention have a substantially increased half-life in plasma compared to proteins not binding serum albumin.
摘要翻译： 描述了对血清白蛋白具有结合特异性的新设计的重复蛋白质，以及编码这种血清白蛋白结合蛋白的核酸，包含这种蛋白质的药物组合物，使用这些蛋白质来改变治疗性相关多肽的药代动力学和使用这种蛋白质 在治疗疾病。 与不结合血清白蛋白的蛋白质相比，本发明的重复蛋白质具有显着增加的血浆半衰期。
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