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公开(公告)号：US07208517B1
公开(公告)日：2007-04-24
申请号：US09653563
申请日：2000-08-31
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King , Todd J. Janus , Robert J. Padley
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King , Todd J. Janus , Robert J. Padley
IPC分类号： A61K31/40
CPC分类号： A61K31/40
摘要： A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, a method of antagonizing endothelin, methods for the inhibition of bone metastases, methods for the prevention of growth of new metastases, methods for the inhibition of bone turnover, and methods for the prevention of bone loss in patients, including cancer patients, using an endothelin ET-A receptor antagonist.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，拮抗内皮素的方法，抑制骨转移的方法，预防生长的方法 的新转移，抑制骨转换的方法，以及使用内皮素ET-A受体拮抗剂预防患者（包括癌症患者）的骨丢失的方法。
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公开(公告)号：US06462194B1
公开(公告)日：2002-10-08
申请号：US09572493
申请日：2000-05-15
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号： C07D26530
CPC分类号： C07D207/27 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59
摘要： A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US06380241B1
公开(公告)日：2002-04-30
申请号：US09714934
申请日：2000-11-17
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号： C07D40502
CPC分类号： C07D207/27 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59
摘要： A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US07365093B2
公开(公告)日：2008-04-29
申请号：US11063476
申请日：2005-02-23
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号： A01N43/36 , C07D405/00
CPC分类号： C07D207/16 , C07D405/04 , C07D405/14 , C07D413/14
摘要： A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US06946481B1
公开(公告)日：2005-09-20
申请号：US10266270
申请日：2002-10-08
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号： A61K31/40 , C07D207/00 , C07D405/04
CPC分类号： C07D405/04
摘要： A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US6162927A
公开(公告)日：2000-12-19
申请号：US905913
申请日：1997-08-04
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号： C07D207/16 , C07D207/26 , C07D207/27 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59 , C07D405/02 , C07D405/06 , A61K41/30 , A61N9/06 , A61N9/10
CPC分类号： C07D207/27 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US5731434A
公开(公告)日：1998-03-24
申请号：US458094
申请日：1995-06-01
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
IPC分类号： C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59
CPC分类号： C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：US5767144A
公开(公告)日：1998-06-16
申请号：US442575
申请日：1995-05-30
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
IPC分类号： C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59 , A61K31/40 , C07D207/08
CPC分类号： C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）的化合物：其中（I）或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US5622971A
公开(公告)日：1997-04-22
申请号：US457935
申请日：1995-06-01
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
IPC分类号： C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59 , A61K31/44 , C07D211/08
CPC分类号： C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）的化合物：其中（I）或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US6124341A
公开(公告)日：2000-09-26
申请号：US87178
申请日：1998-05-29
申请人： Andrew S. Tasker , Martin Winn , Steven A. Boyd , Hwan-Soo Jae , Thomas W. von Geldern , Bryan K. Sorensen , Kenneth J. Henry
发明人： Andrew S. Tasker , Martin Winn , Steven A. Boyd , Hwan-Soo Jae , Thomas W. von Geldern , Bryan K. Sorensen , Kenneth J. Henry
IPC分类号： A61P9/00 , C07D405/04 , A61K31/4025 , C07D403/10
CPC分类号： C07D405/04
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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