公开(公告)号：US20050114801A1

公开(公告)日：2005-05-26

申请号：US10956878

申请日：2004-10-01

申请人： Mary Yang ,  Edward Bylina ,  William Coleman ,  Michael Dilworth ,  Steven Robles ,  Douglas Youvan

发明人： Mary Yang ,  Edward Bylina ,  William Coleman ,  Michael Dilworth ,  Steven Robles ,  Douglas Youvan

IPC分类号： G06K9/00 ,  G06K9/62 ,  G06T5/00 ,  G06T11/20 ,  G06K9/20

CPC分类号： G06K9/00127 ,  G06K9/0014 ,  G06K9/0063 ,  G06K9/6253 ,  G06K2009/00644 ,  G06K2009/4657 ,  G06T7/0012 ,  G06T2200/24 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/30024 ,  Y10S128/922 ,  Y10S707/99937

摘要： Complex multidimensional datasets generated by digital imaging spectroscopy can be organized and analyzed by applying software and computer-based methods comprising sorting algorithms. Combinations of these algorithms to images and graphical data, allow pixels or features to be rapidly and efficiently classified into meaningful groups according to defined criteria. Multiple rounds of pixel or feature selection may be performed based on independent sorting criteria. In one embodiment sorting by spectral criteria (e.g., intensity at a given wavelength) is combined with sorting by temporal criteria (e.g., absorbance at a given time) to identify microcolonies of recombinant organisms harboring mutated genes encoding enzymes having desirable kinetic attributes and substrate specificity. Restriction of the set of pixels analyzed in a subsequent sort based on criteria applied in an earlier sort (“sort and lock” analyses) minimize computational and storage resources. User-defined criteria can also be incorporated into the sorting process by means of a graphical user interface that comprises a visualization tools including a contour plot, a sorting bar and a grouping bar, an image window, and a plot window that allow run-time interactive identification of pixels or features meeting one or more criteria, and display of their associated spectral or kinetic data. These methods are useful for extracting information from imaging data in applications ranging from biology and medicine to remote sensing.

摘要翻译： 通过数字成像光谱法生成的复杂多维数据集可以通过应用软件和基于计算机的方法进行组织和分析，包括排序算法。 这些算法与图像和图形数据的组合允许像素或特征根据定义的标准快速有效地分类为有意义的组。 可以基于独立排序标准来执行多轮像素或特征选择。 在一个实施方案中，通过光谱标准（例如，给定波长处的强度）的排序与通过时间标准（例如，给定时间的吸光度）排序相结合，以鉴定携带突变基因的重组体的微菌落，所述突变基因编码具有期望的动力学属性和底物特异性的酶 。 基于先前排序（“排序和锁定”分析）中应用的标准，在后续排序中分析的像素集合的限制最小化了计算和存储资源。 用户定义的标准也可以通过包括可视化工具的图形用户界面结合到分类过程中，该可视化工具包括轮廓图，分类栏和分组条，图像窗口和允许运行时间的绘图窗口 满足一个或多个标准的像素或特征的交互式识别，以及它们相关联的光谱或动力学数据的显示。 这些方法可用于从生物学和医学到遥感等应用中从成像数据中提取信息。

公开(公告)号：US20070217689A1

公开(公告)日：2007-09-20

申请号：US11750107

申请日：2007-05-17

申请人： Mary Yang ,  Edward Bylina ,  William Coleman ,  Michael Dilworth ,  Steven Robles ,  Douglas Youvan

发明人： Mary Yang ,  Edward Bylina ,  William Coleman ,  Michael Dilworth ,  Steven Robles ,  Douglas Youvan

IPC分类号： G06K9/68

CPC分类号： G06K9/00127 ,  G06K9/0014 ,  G06K9/0063 ,  G06K9/6253 ,  G06K2009/00644 ,  G06K2009/4657 ,  G06T7/0012 ,  G06T2200/24 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/30024 ,  Y10S128/922 ,  Y10S707/99937

摘要： Complex multidimensional datasets generated by digital imaging spectroscopy can be organized and analyzed by applying software and computer-based methods comprising sorting algorithms. Combinations of these algorithms to images and graphical data, allow pixels or features to be rapidly and efficiently classified into meaningful groups according to defined criteria. Multiple rounds of pixel or feature selection may be performed based on independent sorting criteria. In one embodiment sorting by spectral criteria (e.g., intensity at a given wavelength) is combined with sorting by temporal criteria (e.g., absorbance at a given time) to identify microcolonies of recombinant organisms harboring mutated genes encoding enzymes having desirable kinetic attributes and substrate specificity. Restriction of the set of pixels analyzed in a subsequent sort based on criteria applied in an earlier sort (“sort and lock” analyses) minimize computational and storage resources. User-defined criteria can also be incorporated into the sorting process by means of a graphical user interface that comprises a visualization tools including a contour plot, a sorting bar and a grouping bar, an image window, and a plot window that allow run-time interactive identification of pixels or features meeting one or more criteria, and display of their associated spectral or kinetic data. These methods are useful for extracting information from imaging data in applications ranging from biology and medicine to remote sensing.

摘要翻译： 通过数字成像光谱法生成的复杂多维数据集可以通过应用软件和基于计算机的方法进行组织和分析，包括排序算法。 这些算法与图像和图形数据的组合允许像素或特征根据定义的标准快速有效地分类为有意义的组。 可以基于独立排序标准来执行多轮像素或特征选择。 在一个实施方案中，通过光谱标准（例如，给定波长处的强度）的排序与通过时间标准（例如，给定时间的吸光度）排序相结合，以鉴定携带突变基因的重组体的微菌落，所述突变基因编码具有期望的动力学属性和底物特异性的酶 。 基于先前排序（“排序和锁定”分析）中应用的标准，在后续排序中分析的像素集合的限制最小化了计算和存储资源。 用户定义的标准也可以通过包括可视化工具的图形用户界面结合到分类过程中，该可视化工具包括轮廓图，分类栏和分组条，图像窗口和允许运行时间的绘图窗口 满足一个或多个标准的像素或特征的交互式识别，以及它们相关联的光谱或动力学数据的显示。 这些方法可用于从生物学和医学到遥感等应用中从成像数据中提取信息。

公开(公告)号：US06738502B1

公开(公告)日：2004-05-18

申请号：US09585951

申请日：2000-06-02

申请人： William Coleman ,  Michael A. Tanner ,  Christopher M. Silva ,  Edward Bylina ,  Steven J. Robles ,  Michael R. Dilworth ,  Douglas C. Youvan ,  Mary M. Yang

发明人： William Coleman ,  Michael A. Tanner ,  Christopher M. Silva ,  Edward Bylina ,  Steven J. Robles ,  Michael R. Dilworth ,  Douglas C. Youvan ,  Mary M. Yang

IPC分类号： G06K900

CPC分类号： G01N21/274 ,  G01N21/6458 ,  G01N2201/127

摘要： The present invention provides an instrument and methods for a multispectral optical technique that can simultaneously classify individual biological cells within mixed populations. This invention, known as Multispectral Taxonomic Identification (MTID), shows that microscopy can be combined with a software analysis program to measure and categorize the fluorescence and other spectroscopically identifiable signals from complex populations of cells in situ, without cultivation. The invention thus enables high-throughput screening of cells for taxonomic classification.

摘要翻译： 本发明提供了一种用于多光谱光学技术的仪器和方法，其可以在混合群体内同时分类各个生物细胞。 称为多光谱分类鉴定（MTID）的本发明表明，显微镜可以与软件分析程序相结合，以便对来自复杂原位细胞群的荧光和其他可光谱鉴定的信号进行原位测量和分类，无需培养。 因此，本发明使得能够进行用于分类分类的细胞的高通量筛选。

公开(公告)号：US20120298125A1

公开(公告)日：2012-11-29

申请号：US13117655

申请日：2011-05-27

申请人： Michael Francis Dube ,  William Coleman

发明人： Michael Francis Dube ,  William Coleman

IPC分类号： A24B15/12 ,  C07C67/08 ,  C07C69/34 ,  A24B15/10

CPC分类号： A24B15/12 ,  A24B15/10 ,  A24B15/24 ,  A24B15/30 ,  A24B15/302 ,  C07C29/095 ,  C07C51/09 ,  C07C67/08 ,  C07C69/34 ,  C07C31/225 ,  C07C69/18 ,  C07C53/08

摘要： A method for producing triacetin from one or more plants of genus Nicotiana is provided. The triacetin can be derived inter alia from Nicotiana species biomass or from seed. In certain embodiments, the triacetin is produced by condensation of glycerin, generated by hydrolysis of acylglycerol-containing starting material derived from tobacco biomass or seed, and acetic acid, also derived from tobacco biomass or seed. The invention also provides articles and compositions including tobacco articles and tobacco compositions that include triacetin produced from one or more plants of genus Nicotiana.

摘要翻译： 提供了从一种或多种烟草属植物生产三醋精的方法。 三醋精可以从烟草属物种生物量或种子中获得。 在某些实施方案中，通过由衍生自烟草生物质或种子的含酰基甘油的原料水解产生的甘油与来自烟草生物质或种子的乙酸的缩合产生三醋精。 本发明还提供了包括烟草制品和烟草组合物的制品和组合物，其包括由一种或多种烟草属植物产生的三醋精。

公开(公告)号：US20070116723A1

公开(公告)日：2007-05-24

申请号：US11483939

申请日：2006-07-10

申请人： William Coleman

发明人： William Coleman

IPC分类号： A61K39/08

CPC分类号： A61K9/0014 ,  A61K38/4893 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  Y02A50/469

摘要： Hyperactive glandular conditions are treated using topically formulated botulinum toxin compositions. In the preferred embodiment of the invention, topical botulinum preparations are applied directly to the skin by a patient as needed to suppress his or her hyperhidrosis, bromhidrosis, chromhidrosis, nevus sudoriferous, acne, seborrhiec dermatitis or other glandular condition. In other embodiments, topical botulinum toxins are applied with the aid of mechanical, electrical, and/or chemical transdermal delivery enhancers.

摘要翻译： 使用局部配制的肉毒杆菌毒素组合物治疗活动过度的腺体病症。 在本发明的优选实施方案中，根据需要，局部用肉毒素制剂直接施用于皮肤，以抑制他或她的多汗症，异色性，色素变性，痣气味，痤疮，皮脂溢性皮炎或其他腺体状况。 在其它实施方案中，借助机械，电和/或化学透皮递送增强剂施用局部肉毒杆菌毒素。

公开(公告)号：US20060279691A1

公开(公告)日：2006-12-14

申请号：US11147608

申请日：2005-06-08

申请人： Marilyn Coleman ,  William Coleman

发明人： Marilyn Coleman ,  William Coleman

IPC分类号： G02C5/00

CPC分类号： G02C13/00 ,  B65D83/0805

摘要： Disclosed are systems and methods for manufacturing sleeves, a sleeve dispenser, and a method of manufacturing inexpensive, throwaway sleeves that may be used to protect temples from chemicals, germs, bacteria, and the like. Sleeves may be inexpensively manufactured using a single inexpensive raw material as well as an inexpensive manufacturing process in which no waste material is produced. Furthermore, sleeves may be produced as a compact roll of sleeves to accommodate unobtrusive placement in areas with limited space, thereby facilitating distribution in space-limited facilities such as hair salons, spas, optometrist or ophthalmologist offices, sunglass shops, and the like. In some embodiments, the sleeves include latitudinal and longitudinal perforations that facilitate removal of pairs of sleeves from the sleeve roll and removal of each of the pair of sleeves from each other. After separation, a sleeve aperture is passed over the temple until it is fully covered and protected.

摘要翻译： 公开了用于制造套筒的系统和方法，套筒分配器和制造便宜的一次性套筒的方法，其可用于保护寺庙免受化学物质，细菌，细菌等的影响。 可以使用单一便宜的原材料廉价地制造套筒，以及不产生废料的廉价的制造工艺。 此外，袖子可以作为紧凑的袖子卷制成，以容纳在有限空间的区域中的不引人注目的布置，从而便于在诸如美发厅，水疗中心，验光师或眼科医生办公室，太阳眼镜店等的空间有限的设施中的分布。 在一些实施例中，套筒包括纬向和纵向穿孔，其有助于从套筒辊中取出成对的套筒并且将一对套筒中的每一个从彼此中移除。 分离后，套筒孔通过镜子，直到其完全被覆盖和保护。

公开(公告)号：US20050248428A1

公开(公告)日：2005-11-10

申请号：US10838898

申请日：2004-05-04

申请人： William Coleman ,  Fonzie Sanders ,  Christopher Yates

发明人： William Coleman ,  Fonzie Sanders ,  Christopher Yates

IPC分类号： H01F20060101 ,  H01F21/12 ,  H01F27/29 ,  H02M5/42

CPC分类号： H01F21/12 ,  H01F27/292 ,  H01F2021/125

摘要： A differential mode inductor includes a first inductor lead that receives a current. A first arm receives the current from the first inductor lead. A center tap receives the current from the first arm. A second arm receives the current from the center tap. The second arm is substantially parallel to the first arm. The current in the first arm flows in the same direction as the current in the second arm. A second inductor receives the current from the second arm.

摘要翻译： 差模电感器包括接收电流的第一电感器引线。 第一臂接收来自第一电感器引线的电流。 中心抽头接收来自第一臂的电流。 第二臂从中心水龙头接收电流。 第二臂基本上平行于第一臂。 第一臂中的电流沿与第二臂中的电流相同的方向流动。 第二电感器接收来自第二臂的电流。

公开(公告)号：US20070169790A1

公开(公告)日：2007-07-26

申请号：US11414285

申请日：2006-04-28

申请人： Robert Castagno ,  William Coleman

发明人： Robert Castagno ,  William Coleman

IPC分类号： A45D40/26

CPC分类号： A45D40/26 ,  A45D19/0008 ,  A45D19/02 ,  A45D2019/0091 ,  A46B9/005 ,  A46B9/023

摘要： Disclosed are apparatus and methods for efficiently and effectively manipulating spreadable materials. Such apparatus and methods may be incorporated for uses such as applying spreadable materials such as hair color, relaxers, and the like to a surface such as the surface of strands of hair for the purpose of highlighting or otherwise processing hair. A variety of applicators including varying edges, surfaces, tapers, and dimensions are disclosed, wherein each applicator configuration creates a different effect when used for hair processing. Furthermore, a hair stylist may select one or more of the disclosed applicators based upon ease of use for the particular hair stylist, personal preference, and/or the type of hair to be processed. The applicators disclosed herein retain their rigidity during use, are fast-drying, create less waste, and are easy to clean. In one embodiment, a user may tailor the applicator's head design to meet his or her personal needs.

摘要翻译： 公开了用于有效和有效地操纵可展开材料的装置和方法。 为了突出或以其他方式加工头发，可以将这种装置和方法结合到诸如将头发颜色，松弛剂等等可涂抹材料用于诸如毛发表面的表面之类的用途。 公开了包括变化的边缘，表面，锥形和尺寸的各种施用器，其中每个施用器构型在用于头发处理时产生不同的效果。 此外，发型师可以基于对特定发型师的易用性，个人喜好和/或待处理的头发的类型来选择所公开的一个或多个涂抹器。 本文公开的施用器在使用期间保持其刚性，快干，产生较少的浪费，并且易于清洁。 在一个实施例中，用户可以定制施用器的头部设计以满足他或她的个人需要。

公开(公告)号：US20070197210A1

公开(公告)日：2007-08-23

申请号：US11361641

申请日：2006-02-23

申请人： William Mosley ,  William Coleman ,  Mark Gloudemans ,  Bror Peterson ,  Jayanti Patel

发明人： William Mosley ,  William Coleman ,  Mark Gloudemans ,  Bror Peterson ,  Jayanti Patel

IPC分类号： H04Q7/20

CPC分类号： H04L27/2624

摘要： Reducing the peak-to-average power ratio of a signal comprises receiving the input signal, where the input signal is associated with at least one unacceptable frequency range. The input signal is clipped about an amplitude range to yield a clipped signal and clipped information, where the clipped information represents intermodulation products. The clipped information is filtered to yield an error signal. The error signal represents a subset of the intermodulation products, where an intermodulation product of the subset corresponds to the unacceptable frequency range. The error signal is subtracted from the input signal to yield an output signal.

摘要翻译： 降低信号的峰均功率比包括接收输入信号，其中输入信号与至少一个不可接受的频率范围相关联。 输入信号被约束在幅度范围内以产生剪辑信号和剪辑信息，其中剪辑的信息表示互调产物。 被剪辑的信息被过滤以产生错误信号。 误差信号表示互调产物的子集，其中子集的互调乘积对应于不可接受的频率范围。 从输入信号中减去误差信号，产生输出信号。

公开(公告)号：US20070069708A1

公开(公告)日：2007-03-29

申请号：US11560441

申请日：2006-11-16

申请人： William Coleman ,  Fonzie Sanders ,  Christopher Yates

发明人： William Coleman ,  Fonzie Sanders ,  Christopher Yates

IPC分类号： G05F1/00

CPC分类号： H01F21/12 ,  H01F27/292 ,  H01F2021/125

摘要： A differential mode inductor includes a first inductor lead that receives a current. A first arm receives the current from the first inductor lead. A center tap receives the current from the first arm. A second arm receives the current from the center tap. The second arm is substantially parallel to the first arm. The current in the first arm flows in the same direction as the current in the second arm. A second inductor receives the current from the second arm.

摘要翻译： 差模电感器包括接收电流的第一电感器引线。 第一臂接收来自第一电感器引线的电流。 中心抽头接收来自第一臂的电流。 第二臂从中心水龙头接收电流。 第二臂基本上平行于第一臂。 第一臂中的电流沿与第二臂中的电流相同的方向流动。 第二电感器接收来自第二臂的电流。