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公开(公告)号：US5440004A
公开(公告)日：1995-08-08
申请号：US238743
申请日：1994-05-05
IPC分类号： C07D317/36 , C08G64/00
CPC分类号： C07D317/36
摘要： A method for the production of an alkylene carbonate at high yields and high selectivity by a reaction between an alkylene glycol and urea, the method being capable to preventing the deposition of a white crystal in the reflux condenser used in a conventional method for the production of alkylene carbonate and the subsequent decrease in the yield, wherein:a gas washing member and a cooling member are disposed above a reaction portion where alkylene glycol and urea are allowed to react,ammonia-containing steam exhausted from the reaction portion is downwardly introduced into the cooling member through the gas washing member,condensate and ammonia gas exhausted from a bottom of the cooling member are gas-liquid separated,the condensate is introduced into the gas washing member, andthe ammonia gas is removed from the reaction system.
摘要翻译： 一种通过亚烷基二醇和尿素之间的反应以高产率和高选择性生产碳酸亚烷基酯的方法，该方法能够防止白色结晶沉积在用于生产 碳酸亚烷基酯和随后的产率降低，其中：气体洗涤部件和冷却部件设置在使亚烷基二醇和尿素反应的反应部分上方，从反应部分排出的含氨蒸气被向下引入 通过气体洗涤部件的冷却部件，从冷却部件的底部排出的冷凝物和氨气体被气液分离，将冷凝物引入到气体洗涤部件中，从反应体系中除去氨气。
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公开(公告)号：US5489702A
公开(公告)日：1996-02-06
申请号：US286203
申请日：1994-08-05
申请人： Masaharu Doya , Ken-ichi Kimizuka , Yutaka Kanbara
发明人： Masaharu Doya , Ken-ichi Kimizuka , Yutaka Kanbara
IPC分类号： B01J21/10 , B01J23/02 , B01J23/06 , B01J23/14 , C07B61/00 , C07C68/00 , C07C68/06 , C07C69/96 , C07D317/36
CPC分类号： C07D317/36 , C07C68/00 , C07C68/065
摘要： A process for the production of a dialkyl carbonate comprisinga first step of reacting an alkylene glycol, or an alkanediol, with urea in the presence of a catalyst to form an alkylene carbonate or a six-membered cyclic carbonate, anda second step of reacting the alkylene carbonate or the six-membered cyclic carbonate with an alcohol in the presence of a catalyst to obtain a dialkyl carbonate and an alkylene glycol, or a dialkyl carbonate and an alkanediol,wherein the alkylene glycol or the alkanediol obtained in the second step is recycled to the first step.
摘要翻译： 一种制备碳酸二烷基酯的方法，包括在催化剂存在下使亚烷基二醇或链烷二醇与脲反应的第一步骤，以形成碳酸亚烃酯或六元环状碳酸酯，第二步是使 碳酸亚烃酯或六元环状碳酸酯与醇在催化剂存在下反应，得到碳酸二烷基酯和亚烷基二醇或碳酸二烷基酯和链烷二醇，其中第二步得到的亚烷基二醇或链烷二醇是 回收到第一步。
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公开(公告)号：US5969187A
公开(公告)日：1999-10-19
申请号：US30794
申请日：1998-02-26
IPC分类号： C07C209/68 , C07C209/86 , C07C211/18 , C07C209/88
CPC分类号： C07C209/86 , C07C209/68
摘要： Provided a process for producing higher content of trans 1,4-bis(aminomethyl)cyclohexane which is used as the raw material for producing polyamides or polyurethanes having physically and chemically excellent properties from 1,4-bis(aminomethyl)cyclohexane which is generally produced by hydrogenation of p-xylylenediamine.That is, a mixture of cis and trans 1,4-bis(aminomethyl)cyclohexane is isomerized by heating at 120 to 250.degree. C. in the presence of a platinum group catalyst to change to trans isomer. 1,4-bis(aminomethyl)cyclohexane containing more than 80% trans isomer is produced by combining this isomerization technique and crystallization technique.
摘要翻译： 提供了用于生产具有物理和化学性质优异的聚酰胺或聚氨酯的原料的反式1,4-双（氨基甲基）环己烷的较高含量的方法，其通常由1,4-双（氨基甲基）环己烷生产 通过对苯二甲胺的氢化。 也就是说，在铂族催化剂的存在下，通过在120-250℃下加热使顺式和反式1,4-双（氨基甲基）环己烷的混合物异构化，以变成反式异构体。 通过组合这种异构化技术和结晶技术产生含有超过80％反式异构体的1,4-双（氨基甲基）环己烷。
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公开(公告)号：US5349077A
公开(公告)日：1994-09-20
申请号：US99461
申请日：1993-07-30
IPC分类号： C07D317/36 , C07D317/38 , C07C69/96
CPC分类号： C07D317/38 , C07D317/36
摘要： A process for producing alkylene carbonates which comprises reacting urea and glycols described by the general formula RCH(OH) CH.sub.2 OH; wherein R represents hydrogen or an alkyl group containing 1 to 4 carbons, using a catalyst containing zinc, magnesium, lead or calcium at reduced pressures. The alkylene carbonates are produced with high yield easily using raw materials which are comparatively inexpensive with a mild reaction that does not involve explosive or hazardous materials.
摘要翻译： 一种制备碳酸亚烷基酯的方法，其包括使通式RCH（OH）CH 2 OH描述的脲和二醇反应; 其中R表示氢或含有1至4个碳的烷基，在减压下使用含锌，镁，铅或钙的催化剂。 碳酸亚烷基酯可以容易地使用相对便宜的不具有爆炸性或有害物质的轻度反应的原料而高产率地制备。
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5.发明授权Process for recimization of an optically active alpha-amino acid amides and process for producing optically active alpha-amino acids 失效用于重新获得光学活性α-氨基酸酰胺的方法和用于制备光学活性α-氨基酸的方法
公开(公告)号：US4918196A
公开(公告)日：1990-04-17
申请号：US831915
申请日：1986-02-21
申请人： Masaharu Doya , Toshio Kondo , Hideo Igarashi , Takako Uchiyama
发明人： Masaharu Doya , Toshio Kondo , Hideo Igarashi , Takako Uchiyama
IPC分类号： C07D233/72 , C12P13/04 , C12P41/00
CPC分类号： C12P41/006 , C12P13/04
摘要： A process for optically isomerizing an optically active alpha-amino acid amide comprising heating a D-alpha-amino acid amide or an L-alpha-amino acid amide in the presence of a strongly basic compound; and a process for producing an L-alpha-amino acid, which comprises(1) subjecting a D,L-alpha-amino acid amide or a mixture of a major amount of a D-alpha-amino acid amide and a minor amount of an L-alpha-amino acid amide to the action of a microorganism having the ability to hydrolyze the L-alpha-amino acid to obtain a hydrolyzate containing the L-alpha-amino acid and D-alpha-amino acid,(2) separating the L-alpha-amino acid from the hydrolyzate and recovering the remaining D-alpha-amino acid amide.(3) heating all or part of the recovered D-alpha-amino acid amide in the presence of a strongly basic substance to obtain a D,L-alpha-amino acid amide or a mixture of a major amount of the D-alpha-amino acid amide and a minor amount of the L-alpha-amino acid amide, and(4) recycling the D,L-alpha-amino acid amide or the mixture to step (1) as part or all of the starting material.
摘要翻译： 包括光学异构化光学活性α-氨基酸酰胺的方法，包括在强碱性化合物存在下加热D-α-氨基酸酰胺或L-α-氨基酸酰胺; 以及制备L-α-氨基酸的方法，其包括（1）使D，L-α-氨基酸酰胺或主要量的D-α-氨基酸酰胺和少量的 L-α-氨基酸酰胺，具有水解L-α-氨基酸的能力的微生物的作用，得到含有L-α-氨基酸和D-α-氨基酸的水解产物，（2）分离 来自水解产物的L-α-氨基酸并回收剩余的D-α-氨基酸酰胺。 （3）在强碱性物质存在下加热全部或部分回收的D-α-氨基酸酰胺，得到D，L-α-氨基酸酰胺或大量D-α-氨基酸酰胺的混合物， 氨基酸酰胺和少量的L-α-氨基酸酰胺，和（4）将D，L-α-氨基酸酰胺或混合物循环到步骤（1）中作为起始原料的一部分或全部。
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6.发明授权Process for production of iodine compounds and process for production of high-purity 5-iodo-2-methylbenzoic acid 失效生产碘化合物的方法和生产高纯度5-碘-2-甲基苯甲酸的方法公开(公告)号：US07750182B2
公开(公告)日：2010-07-06
申请号：US10545005
申请日：2004-02-10
CPC分类号： C07C253/30 , C07B39/00 , C07C17/12 , C07C17/156 , C07C17/158 , C07C51/363 , C07C51/43 , C07C25/02 , C07C25/13 , C07C25/18 , C07C25/125 , C07C63/70 , C07C255/50
摘要： Provided is a production method for an iodine compound in which iodine is reacted with a substrate in the presence of a porous material having a pore diameter of 500 nm or less or in the presence of the above porous material and an oxidizing agent and a production process for high purity 5-iodo-2-methylbenzoic acid comprising an iodination reaction step carried out by the above-mentioned, a crystal precipitation and separation step in which a product is precipitated by adding water or cooling and then separated and a purification step in which crystal separated is recrystallized using an organic solvent. According to the production method for an iodine compound described above, iodine can be introduced into various substrates at a high selectivity. Since expensive metals and specific reagents do not have to be used, it can readily be carried out in an industrially scale, and the product having a high purity can be obtained. Further, the process comprising the iodination reaction, separation and purification steps described above makes it possible to readily obtain at a high yield, 5-iodo-2-methylbenzoic acid having a high purity which is useful in uses for functional chemical products such as medicines. The process of the present invention comprising iodination reaction, separation and purification steps is characterized by that it is simple in terms of a procedure and that the purification load is smaller, and it is very advantageous in industrially carrying out.
摘要翻译： 提供一种碘化合物的制造方法，其中碘在孔径为500nm以下的多孔质材料的存在下，或者在上述多孔质材料和氧化剂的存在下，与基材反应，制造方法 包括通过上述进行的碘化反应步骤的高纯度5-碘-2-甲基苯甲酸，其中通过加入水或冷却然后分离产物而沉淀产物的晶体沉淀和分离步骤和纯化步骤，其中 使用有机溶剂重结晶晶体分离。 根据上述碘化合物的制造方法，能够以高选择性将碘引入各种基材中。 由于不需要使用昂贵的金属和特定试剂，因此可以容易地以工业规模进行，可以获得高纯度的产物。 此外，包括上述碘化反应，分离和纯化步骤的方法使得可以容易地以高产率获得具有高纯度的5-碘-2-甲基苯甲酸，其可用于诸如药物的功能性化学产品的用途 。 包括碘化反应，分离和纯化步骤的本发明方法的特征在于它在程序方面简单，净化负荷较小，在工业上非常有利。
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7.发明申请Process for production of iodine compounds and process for production of high-purity 5-iodo-2-methylbenzoic acid 失效生产碘化合物的方法和生产高纯度5-碘-2-甲基苯甲酸的方法公开(公告)号：US20060161028A1
公开(公告)日：2006-07-20
申请号：US10545005
申请日：2004-02-10
IPC分类号： C07C17/00
CPC分类号： C07C253/30 , C07B39/00 , C07C17/12 , C07C17/156 , C07C17/158 , C07C51/363 , C07C51/43 , C07C25/02 , C07C25/13 , C07C25/18 , C07C25/125 , C07C63/70 , C07C255/50
摘要： Provided is a production method for an iodine compound in which iodine is reacted with a substrate in the presence of a porous material having a pore diameter of 500 nm or less or in the presence of the above porous material and an oxidizing agent and a production process for high purity 5-iodo-2-methylbenzoic acid comprising an iodination reaction step carried out by the above-mentioned, a crystal precipitation and separation step in which a product is precipitated by adding water or cooling and then separated and a purification step in which crystal separated is recrystallized using an organic solvent. According to the production method for an iodine compound described above, iodine can be introduced into various substrates at a high selectivity. Since expensive metals and specific reagents do not have to be used, it can readily be carried out in an industrially scale, and the product having a high purity can be obtained. Further, the process comprising the iodination reaction, separation and purification steps described above makes it possible to readily obtain at a high yield, 5-iodo-2-methylbenzoic acid having a high purity which is useful in uses for functional chemical products such as medicines. The process of the present invention comprising iodination reaction, separation and purification steps is characterized by that it is simple in terms of a procedure and that the purification load is smaller, and it is very advantageous in industrially carrying out.
摘要翻译： 提供一种碘化合物的制造方法，其中碘在孔径为500nm以下的多孔质材料的存在下，或者在上述多孔质材料和氧化剂的存在下，与基材反应，制造方法 包括通过上述进行的碘化反应步骤的高纯度5-碘-2-甲基苯甲酸，其中通过加入水或冷却然后分离产物而沉淀产物的晶体沉淀和分离步骤和纯化步骤，其中 使用有机溶剂重结晶晶体分离。 根据上述碘化合物的制造方法，能够以高选择性将碘引入各种基材中。 由于不需要使用昂贵的金属和特定试剂，因此可以容易地以工业规模进行，可以获得高纯度的产物。 此外，包括上述碘化反应，分离和纯化步骤的方法使得可以容易地以高产率获得具有高纯度的5-碘-2-甲基苯甲酸，其可用于诸如药物的功能性化学产品的用途 。 包括碘化反应，分离和纯化步骤的本发明方法的特征在于它在程序方面简单，净化负荷较小，在工业上非常有利。
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公开(公告)号：US4605477A
公开(公告)日：1986-08-12
申请号：US704596
申请日：1985-02-25
申请人： Masaharu Doya , Toshio Kondo , Hideo Igarashi , Takako Uchiyama
发明人： Masaharu Doya , Toshio Kondo , Hideo Igarashi , Takako Uchiyama
IPC分类号： C07C319/28 , C07C67/00 , C07C227/00 , C07C227/40 , C07C229/02 , C07C313/00 , C07C323/58 , C12P13/04 , B01D13/02
CPC分类号： B01D61/44 , C12P13/04 , B01D2311/2623
摘要： An .alpha.-amino acid is effectively separated and recovered from an aqueous solution containing at least an .alpha.-amino acid and its corresponding .alpha.-amino acid amide by performing ion-exchange electrodialysis in the presence of ammonia. A reaction product liquid obtained by biochemical asymmetric hydrolysis of a D, L-.alpha.-amino acid is used preferably as the raw material aqueous solution for dialysis.
摘要翻译： 通过在氨的存在下进行离子交换电渗析，从含有至少α-氨基酸及其相应的α-氨基酰胺的水溶液中有效地分离和回收α-氨基酸。 优选使用通过D，L-α-氨基酸的生物化学不对称水解获得的反应产物作为用于透析的原料水溶液。
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公开(公告)号：US06174711B1
公开(公告)日：2001-01-16
申请号：US09351619
申请日：1999-07-12
IPC分类号： C12P1306
CPC分类号： C07C237/06 , C07C231/10 , C07D317/30 , C07D319/06 , C12P41/006
摘要： A method for producing L-allysine acetal represented by general formula (II), comprising reacting D,L-allysinamide acetal represented by general formula (I) with cells of microorganism or treated cell product having an activity of stereoselectively hydrolyzing L-allysinamide acetal, wherein R1 and R2, which may be the same or different, each independently represent a lower alkyl group, or R1 and R2 are combined to form an alkylene group represented by [CH2]n, and n is 2 to 3. D,L-allysinamide acetal represented by general formula (I) is also in the scope of the invention. According to the present invention, L-allysine acetal useful as a raw material for medicine can be produced in a smaller number of steps at low costs.
摘要翻译： 一种由通式（II）表示的L-烯丙基乙缩醛的制备方法，其特征在于，将由通式（I）表示的D，L-烯丙基酰胺缩醛与具有立体选择性水解L-烯丙基酰胺缩醛活性的微生物或经处理的细胞产物反应， 其中R 1和R 2可以相同或不同，各自独立地表示低级烷基，或者R 1和R 2结合形成由[CH 2] n表示的亚烷基，n为2至3.D，L- 由通式（I）表示的烯丙基酰胺缩醛也在本发明的范围内。 根据本发明，可以低成本地以较少数量的步骤生产用作医药原料的L-烯丙基乙缩醛。
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公开(公告)号：US4328374A
公开(公告)日：1982-05-04
申请号：US166114
申请日：1980-07-07
申请人： Shigeo Yoshinaka , Masaharu Doya
发明人： Shigeo Yoshinaka , Masaharu Doya
IPC分类号： C07C47/544 , C07C17/14 , C07C45/00 , C07C45/27 , C07C45/80 , C07C45/81 , C07C67/00 , C07C45/28
摘要： A process for the production of aromatic dialdehydes which comprises reacting xylene chloride selected from the group consisting of .alpha.,.alpha.,.alpha.'-trichloroxylene alone, or a mixture of .alpha.,.alpha.,.alpha.'-trichloroxylene and .alpha.,.alpha.'-dichloroxylene, a mixture of .alpha.,.alpha.,.alpha.'-trichloroxylene and .alpha.,.alpha.,.alpha.',.alpha.'-tetrachloroxylene and a mixture of .alpha.,.alpha.,.alpha.'-trichloroxylene, .alpha.,.alpha.'-dichloroxylene and .alpha.,.alpha.,.alpha.',.alpha.'-tetrachloroxylene with nitric acid.
摘要翻译： 一种制备芳族二醛的方法，其包括使选自α，α，α'-三氯代二氧化硅或单独的α，α，α'-三氯代二甲苯和α，α'-二氯二氧化硅的混合物的二甲苯氯反应， α，α，α'-三氯代二甲苯和α，α，α'，α'-四氯代二甲苯和α，α，α'-三氯代二甲苯，α，α'-二氯二氧化碳和α，α，α'，α ' - 四氯二氧化硅与硝酸。
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