公开(公告)号：US20090297503A1

公开(公告)日：2009-12-03

申请号：US12395909

申请日：2009-03-02

申请人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

发明人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P7/00

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

摘要： For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.

摘要翻译： 本发明首次提供增强活化凝血因子VIII产生的抗体。 抗体增强了位置372的Arg处的凝血因子VIII的切割，并通过识别和结合凝血因子VIII的A2结构域来抑制位置336的Arg的切割。 预期这样的抗体可用于预防或治疗由于凝血因子VIII活性降低或丧失而发展或进展的疾病，例如血友病A，获得性血友病和血管性血友病。

公开(公告)号：US08252287B2

公开(公告)日：2012-08-28

申请号：US12395909

申请日：2009-03-02

申请人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

发明人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

IPC分类号： A61K39/395

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

摘要： For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.

摘要翻译： 本发明首次提供增强活化凝血因子VIII产生的抗体。 抗体增强了位置372的Arg处的凝血因子VIII的切割，并通过识别和结合凝血因子VIII的A2结构域来抑制位置336的Arg的切割。 预期这样的抗体可用于预防或治疗由于凝血因子VIII活性降低或丧失而发展或进展的疾病，例如血友病A，获得性血友病和血管性血友病。

公开(公告)号：US20060068454A1

公开(公告)日：2006-03-30

申请号：US11234114

申请日：2005-09-26

申请人： Masahiro Okuda ,  Yoshihito Yamamoto ,  Akira Yoshioka ,  Midori Shima ,  Masahiro Takeyama

发明人： Masahiro Okuda ,  Yoshihito Yamamoto ,  Akira Yoshioka ,  Midori Shima ,  Masahiro Takeyama

IPC分类号： C12Q1/56

CPC分类号： G01N33/86

摘要： A method of inactivating a blood coagulation factor is described. The method comprises a step of contacting a sample containing at least one of factors V and VIII with a compound having an iminodiacetate group, whereby at least one of factors V and VIII in the sample is changed into an inactivated form.

摘要翻译： 描述了使凝血因子失活的方法。 该方法包括将含有至少一种因子V和VIII的样品与具有亚氨基二乙酸酯基团的化合物接触的步骤，由此将样品中的因子V和VIII中的至少一种变为失活形式。

公开(公告)号：US20090092958A1

公开(公告)日：2009-04-09

申请号：US12237175

申请日：2008-09-24

申请人： Masahiro OKUDA ,  Yoshihito Yamamoto ,  Akira Yoshioka ,  Midori Shima ,  Masahiro Takeyama

发明人： Masahiro OKUDA ,  Yoshihito Yamamoto ,  Akira Yoshioka ,  Midori Shima ,  Masahiro Takeyama

IPC分类号： A01N1/02

CPC分类号： G01N33/86

摘要： A method of inactivating a blood coagulation factor is described. The method comprises a step of contacting a sample containing at least one of factors V and VIII with a compound having an iminodiacetate group, whereby at least one of factors V and VIII in the sample is changed into an inactivated form.

摘要翻译： 描述了使凝血因子失活的方法。 该方法包括将含有至少一种因子V和VIII的样品与具有亚氨基二乙酸酯基团的化合物接触的步骤，由此将样品中的因子V和VIII中的至少一种变为灭活形式。