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    Apparatus for manufacturing low-oxygen copper
    1.
    发明授权
    Apparatus for manufacturing low-oxygen copper 有权
    低氧铜制造装置

    公开(公告)号：US06589473B2

    公开(公告)日：2003-07-08

    申请号：US09789594

    申请日：2001-02-22

    申请人： Haruhiko Asao ,  Yutaka Koshiba ,  Keiji Nogami ,  Tutomu Masui ,  Kazumasa Hori ,  Kenji Wakiguchi ,  Masahiko Wada ,  Yoshiaki Hattori

    发明人： Haruhiko Asao ,  Yutaka Koshiba ,  Keiji Nogami ,  Tutomu Masui ,  Kazumasa Hori ,  Kenji Wakiguchi ,  Masahiko Wada ,  Yoshiaki Hattori

    IPC分类号： C21D952

    CPC分类号： B22D11/005 ,  B22D11/00 ,  B22D11/0602 ,  B22D11/11 ,  B22D11/113 ,  C22B9/006 ,  C22B9/05 ,  C22B15/006 ,  Y10S29/005 ,  Y10T29/49988 ,  Y10T29/49989 ,  Y10T29/49991

    摘要： An apparatus for manufacturing a copper wire includes a melting furnace in which combustion is performed in a reducing atmosphere so as to produce molten copper; a holding furnace for maintaining a predetermined temperature of the molten copper supplied from the melting furnace; a casting trough for sealing the molten copper supplied from the holding furnace in a non-oxidizing atmosphere and for transferring the molten copper to a tundish; a degasser provided in the casting trough for dehydrogenating the molten copper passing therethrough; a continuous casting machine for continuously producing cast copper from the molten copper supplied from the tundish, and a cutter for cutting the cast copper into a predetermined length. The apparatus permits a dehydrogenating treatment to be performed without requiring a long moving distance of molten copper, and in which the generation of holes in solidification is suppressed, whereby high quality low-oxygen copper wire having superior surface quality can be obtained.

    摘要翻译： 一种铜线的制造装置，其特征在于，包括：在还原气氛中进行燃烧以产生熔融铜的熔化炉; 用于保持从熔化炉供给的熔融铜的预定温度的保持炉; 用于在非氧化气氛中密封从保持炉供应的熔融铜并将熔融铜转移到中间包的铸槽; 设置在铸槽中的用于使通过其中的熔融铜脱氢的脱气机; 用于从中间包提供的熔融铜连续生产铸铜的连续铸造机和用于将铸铜切割成预定长度的切割机。 该设备允许进行脱氢处理而不需要熔融铜的长移动距离，并且其中凝固孔产生被抑制，从而可以获得具有优异表面质量的高质量低氧铜线。

    Apparatus and method for manufacturing copper-base alloy
    2.
    发明授权
    Apparatus and method for manufacturing copper-base alloy 失效
    铜基合金的制造方法及装置

    公开(公告)号：US5062614A

    公开(公告)日：1991-11-05

    申请号：US90652

    申请日：1987-08-28

    申请人： Izumi Sukekawa ,  Haruhiko Asao ,  Hiroshi Kohno ,  Yukio Sugawara ,  Keiji Nogami

    发明人： Izumi Sukekawa ,  Haruhiko Asao ,  Hiroshi Kohno ,  Yukio Sugawara ,  Keiji Nogami

    IPC分类号： C22C9/00 ,  B22D11/11 ,  C22C1/02

    CPC分类号： B22D11/11

    摘要： There are provided an apparatus and a method for manufacturing a copper-base alloy. The apparatus includes an alloying spout, at least one feeder and a tundish. The tundish is inclined downwardly from one end toward the other end for flowing a molten copper therethrough. The feeder is connected to the alloying spout for introducing at least one solid solute constituent into the alloying spout. The method includes the steps of providing the above apparatus, continuously introducing the molten copper from the inlet into the passageway of the alloying spout and causing the molten copper to flow downwardly through the passageway to the outlet, and continuously introducing the solid solute constitutent into the passageway of the alloying spout through the feeder to mix the solute constituent with the molten copper to produce the copper-base alloy.

    摘要翻译： 提供了一种用于制造铜基合金的装置和方法。 该装置包括合金喷口，至少一个进料器和中间包。 中间包从一端朝向另一端向下倾斜，用于使熔融铜流过。 进料器连接到合金喷口，用于将至少一个固体溶质成分引入到合金喷口中。 该方法包括以下步骤：提供上述装置，将熔融铜从入口连续引入合金喷口的通道中，并使熔融铜从通道向下流出到出口，并将固体溶质组分连续引入 合金喷口通过进料器的通道，以将溶质组分与熔融铜混合以产生铜基合金。

    Blood Coagulation Factor VIII Activation-Enhancing Antibodies
    4.
    发明申请
    Blood Coagulation Factor VIII Activation-Enhancing Antibodies 有权
    血液凝固因子VIII激活增强抗体

    公开(公告)号：US20090297503A1

    公开(公告)日：2009-12-03

    申请号：US12395909

    申请日：2009-03-02

    申请人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

    发明人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P7/00

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

    摘要： For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.

    摘要翻译： 本发明首次提供增强活化凝血因子VIII产生的抗体。 抗体增强了位置372的Arg处的凝血因子VIII的切割，并通过识别和结合凝血因子VIII的A2结构域来抑制位置336的Arg的切割。 预期这样的抗体可用于预防或治疗由于凝血因子VIII活性降低或丧失而发展或进展的疾病，例如血友病A，获得性血友病和血管性血友病。

    Blood coagulation factor VIII activation-enhancing antibodies
    6.
    发明授权
    Blood coagulation factor VIII activation-enhancing antibodies 有权
    血液凝固因子VIII激活增强抗体

    公开(公告)号：US08252287B2

    公开(公告)日：2012-08-28

    申请号：US12395909

    申请日：2009-03-02

    申请人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

    发明人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

    IPC分类号： A61K39/395

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

    摘要： For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.

    摘要翻译： 本发明首次提供增强活化凝血因子VIII产生的抗体。 抗体增强了位置372的Arg处的凝血因子VIII的切割，并通过识别和结合凝血因子VIII的A2结构域来抑制位置336的Arg的切割。 预期这样的抗体可用于预防或治疗由于凝血因子VIII活性降低或丧失而发展或进展的疾病，例如血友病A，获得性血友病和血管性血友病。

    Method for manufacturing low-oxygen copper
    7.
    发明授权
    Method for manufacturing low-oxygen copper 有权
    低氧铜制造方法

    公开(公告)号：US07524356B2

    公开(公告)日：2009-04-28

    申请号：US11194568

    申请日：2005-08-02

    申请人： Haruhiko Asao ,  Yutaka Koshiba ,  Keiji Nogami ,  Tutomu Masui ,  Kazumasa Hori ,  Kenji Wakiguchi ,  Masahiko Wada ,  Yoshiaki Hattori

    发明人： Haruhiko Asao ,  Yutaka Koshiba ,  Keiji Nogami ,  Tutomu Masui ,  Kazumasa Hori ,  Kenji Wakiguchi ,  Masahiko Wada ,  Yoshiaki Hattori

    IPC分类号： C22B15/00 ,  C22C9/00

    CPC分类号： B22D11/005 ,  B22D11/00 ,  B22D11/0602 ,  B22D11/11 ,  B22D11/113 ,  C22B9/006 ,  C22B9/05 ,  C22B15/006 ,  Y10S29/005 ,  Y10T29/49988 ,  Y10T29/49989 ,  Y10T29/49991

    摘要： A method for manufacturing a low-oxygen copper wire is provided, in which a dehydrogenating treatment can be performed without requiring a long moving distance of molten copper, and the generation of holes in solidification is suppressed, whereby high quality low-oxygen copper wire can be obtained having superior surface quality. The method for continuously manufacturing ingots of low-oxygen copper from molten copper includes a step of performing combustion in a reducing atmosphere in a melting furnace so as to produce molten copper; a step of sealing the molten copper in a non-oxidizing atmosphere in a casting trough; a step of transferring the molten copper to a tundish by using the casting trough; a degassing step of passing the molten copper through a degasser provided in the casting trough so as to dehydrogenate the molten copper; a step of continuously feeding the molten copper to a continuous casting machine so as to continuously produce cast copper; and a step of cutting the cast copper into a predetermined length.

    摘要翻译： 提供一种制造低氧铜线的方法，其中可以进行脱氢处理而不需要长时间的熔融铜的移动距离，并且可以抑制凝固孔的产生，从而优质的低氧铜线可以 获得具有优异的表面质量。 从熔融铜连续生产低氧铜锭的方法包括在熔炉中在还原气氛中进行燃烧以产生熔融铜的步骤; 在铸造槽中的非氧化性气氛中密封熔融铜的工序; 通过使用铸造槽将熔融铜转移到中间包的步骤; 使熔融铜通过设置在铸造槽中的脱气器以使熔融铜脱氢的脱气步骤; 连续地将熔融铜进料到连续铸造机上以连续生产铸铜的步骤; 以及将铸铜切割成预定长度的步骤。

    Method for manufacturing copper-base alloy
    9.
    发明授权
    Method for manufacturing copper-base alloy 失效
    铜基合金的制造方法

    公开(公告)号：US4981514A

    公开(公告)日：1991-01-01

    申请号：US384268

    申请日：1989-07-24

    申请人： Izumi Sukekawa ,  Haruhiko Asao ,  Hiroshi Kohno ,  Yukio Sugawara ,  Keiji Nogami

    发明人： Izumi Sukekawa ,  Haruhiko Asao ,  Hiroshi Kohno ,  Yukio Sugawara ,  Keiji Nogami

    IPC分类号： B22D11/11

    CPC分类号： B22D11/11

    摘要： There are provided an apparatus and a method for manufacturing a copper-base alloy. The apparatus includes an alloying spout, at least one feeder and a tundish. The tundish is inclined downwardly from one end toward the other end for flowing a molten copper therethrough. The feeder is connected to the alloying spout for introducing at least one solid solute constituent into the alloying spout. The method includes the steps of providing the above apparatus, continuously introducing the molten copper from the inlet into the passageway of the alloying spout and causing the molten copper to flow downwardly through the passageway to the outlet, and continuously introducing the solid state constituent into the passageway of the alloying spout through the feeder to mix the solute constituent with the molten copper to produce the copper-base alloy.

    摘要翻译： 提供了一种用于制造铜基合金的装置和方法。 该装置包括合金喷口，至少一个进料器和中间包。 中间包从一端朝向另一端向下倾斜，用于使熔融铜流过。 进料器连接到合金喷口，用于将至少一个固体溶质成分引入到合金喷口中。 该方法包括以下步骤：提供上述装置，将熔融铜从入口连续引入合金喷口的通道中，并使熔融铜从通道向下流动到出口，并将固态成分连续引入 合金喷口通过进料器的通道，以将溶质组分与熔融铜混合以产生铜基合金。