公开(公告)号：US20060068454A1

公开(公告)日：2006-03-30

申请号：US11234114

申请日：2005-09-26

申请人： Masahiro Okuda ,  Yoshihito Yamamoto ,  Akira Yoshioka ,  Midori Shima ,  Masahiro Takeyama

发明人： Masahiro Okuda ,  Yoshihito Yamamoto ,  Akira Yoshioka ,  Midori Shima ,  Masahiro Takeyama

IPC分类号： C12Q1/56

CPC分类号： G01N33/86

摘要： A method of inactivating a blood coagulation factor is described. The method comprises a step of contacting a sample containing at least one of factors V and VIII with a compound having an iminodiacetate group, whereby at least one of factors V and VIII in the sample is changed into an inactivated form.

摘要翻译： 描述了使凝血因子失活的方法。 该方法包括将含有至少一种因子V和VIII的样品与具有亚氨基二乙酸酯基团的化合物接触的步骤，由此将样品中的因子V和VIII中的至少一种变为失活形式。

公开(公告)号：US20090092958A1

公开(公告)日：2009-04-09

申请号：US12237175

申请日：2008-09-24

申请人： Masahiro OKUDA ,  Yoshihito Yamamoto ,  Akira Yoshioka ,  Midori Shima ,  Masahiro Takeyama

发明人： Masahiro OKUDA ,  Yoshihito Yamamoto ,  Akira Yoshioka ,  Midori Shima ,  Masahiro Takeyama

IPC分类号： A01N1/02

CPC分类号： G01N33/86

摘要： A method of inactivating a blood coagulation factor is described. The method comprises a step of contacting a sample containing at least one of factors V and VIII with a compound having an iminodiacetate group, whereby at least one of factors V and VIII in the sample is changed into an inactivated form.

摘要翻译： 描述了使凝血因子失活的方法。 该方法包括将含有至少一种因子V和VIII的样品与具有亚氨基二乙酸酯基团的化合物接触的步骤，由此将样品中的因子V和VIII中的至少一种变为灭活形式。

公开(公告)号：US08252287B2

公开(公告)日：2012-08-28

申请号：US12395909

申请日：2009-03-02

申请人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

发明人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

IPC分类号： A61K39/395

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

摘要： For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.

摘要翻译： 本发明首次提供增强活化凝血因子VIII产生的抗体。 抗体增强了位置372的Arg处的凝血因子VIII的切割，并通过识别和结合凝血因子VIII的A2结构域来抑制位置336的Arg的切割。 预期这样的抗体可用于预防或治疗由于凝血因子VIII活性降低或丧失而发展或进展的疾病，例如血友病A，获得性血友病和血管性血友病。

公开(公告)号：US20090297503A1

公开(公告)日：2009-12-03

申请号：US12395909

申请日：2009-03-02

申请人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

发明人： Masahiro Takeyama ,  Keiji Nogami ,  Midori Shima ,  Tsukasa Suzuki

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P7/00

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

摘要： For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.

摘要翻译： 本发明首次提供增强活化凝血因子VIII产生的抗体。 抗体增强了位置372的Arg处的凝血因子VIII的切割，并通过识别和结合凝血因子VIII的A2结构域来抑制位置336的Arg的切割。 预期这样的抗体可用于预防或治疗由于凝血因子VIII活性降低或丧失而发展或进展的疾病，例如血友病A，获得性血友病和血管性血友病。

公开(公告)号：US20130004755A1

公开(公告)日：2013-01-03

申请号：US13635031

申请日：2011-03-22

申请人： Naoki Fukumura ,  Masahiro Takeyama ,  Ryo Nakazawa

发明人： Naoki Fukumura ,  Masahiro Takeyama ,  Ryo Nakazawa

IPC分类号： C09D129/10 ,  B32B7/02 ,  B32B19/04 ,  C08K5/17 ,  B32B27/08 ,  B05D7/24 ,  B05D3/02 ,  B32B17/10 ,  B32B15/08

CPC分类号： C09D129/10 ,  C08K5/0091 ,  C08K5/057 ,  C08K5/098 ,  C08K2201/019 ,  C09D5/002 ,  C09D5/08 ,  C09D127/12 ,  C09D127/18 ,  Y10T428/24967 ,  Y10T428/269 ,  C08L27/12 ,  C08L27/18

摘要： A chromium-free fluoropolymer-containing primer composition, which can provide a coated article having excellent higher corrosion resistance by forming a fluoropolymer coating film, and a primer layer having sufficient adhesive strength to the fluoropolymer coating film on the surface of a substrate such as metal, glass, ceramic and heat resistant plastics, a method for manufacturing a coating film using the same, and a coated article using the same. The coating composition contains at least one kind of a fluoropolymer component selected from a reactive functional group-containing fluoropolymer, and a fluoropolymer having a melt flow rate (MFR), measured under a load of 5 kg and at 372° C., in accordance with ASTM D1238, of 10 to 100 g/10 minutes, and an organic titanate, wherein content of titanium contained in the organic titanate, relative to the fluoropolymer component, is 1 to 40% by weight.

摘要翻译： 一种含铬含氟聚合物的底漆组合物，其可以通过形成含氟聚合物涂膜来提供具有优异的较高耐腐蚀性的涂布制品，以及对诸如金属的基材的表面上的含氟聚合物涂膜具有足够的粘合强度的底漆层 玻璃，陶瓷和耐热塑料，使用其的涂膜的制造方法和使用其的涂布制品。 涂料组合物含有选自含有反应性官能团的含氟聚合物中的至少一种含氟聚合物组分和在5kg负荷和372℃下按照下式测量的熔体流动速率（MFR）的含氟聚合物 ASTM D1238为10〜100g / 10分钟，有机钛酸酯相对于含氟聚合物成分含有的钛的含量为1〜40重量％。

公开(公告)号：US4278980A

公开(公告)日：1981-07-14

申请号：US24854

申请日：1979-03-28

申请人： Minoru Ogita ,  Masahiro Takeyama

发明人： Minoru Ogita ,  Masahiro Takeyama

IPC分类号： H01Q7/06 ,  H01Q1/24 ,  H01Q7/00 ,  H01Q21/00 ,  H01Q21/30

CPC分类号： H01Q21/30 ,  H01Q1/24 ,  H01Q21/00 ,  H01Q7/00

摘要： A low-impedance loop antenna for receiving medium-frequency-band radio waves has an inductance of 1 microhenry up to 100 microhenries and an effective loop area larger than 20 cm.sup.2, whereby it is capable of receiving radio waves with a markedly improved rejection of undersirable radiations in the form of electric field from external noise sources. Such low-impendance loop antenna is coupled to a radio receiver via an input transformer whereat the impedance of this antenna is stepped up for the purpose of impedance matching. The input transformer has a primary winding provided with a tap adapted to be connected to the antenna and whose ends are connected to a variable capacitor constituting a tuning circuit jointly with the input transformer.

摘要翻译： 用于接收中频带无线电波的低阻环路天线的电感为1微亨，高达100微亨，有效回路面积大于20平方厘米，从而能够接收无线电波，显着改善对不可取的 来自外部噪声源的电场形式的辐射。 这种低阻抗环形天线经由输入变压器耦合到无线电接收机，其中该天线的阻抗被加强以用于阻抗匹配。 输入变压器具有初级绕组，其具有适于连接到天线的抽头，并且其端部与构成与输入变压器组合的调谐电路的可变电容器连接。