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    Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same
    2.
    发明授权
    Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same 失效
    酰氨基酸的吡咯烷酰胺衍生物和含有它们的药物组合物

    公开(公告)号：US5198458A

    公开(公告)日：1993-03-30

    申请号：US638148

    申请日：1991-01-09

    申请人： Naoki Higuchi ,  Masayuki Saitoh ,  Masaki Hashimoto ,  Harukazu Fukami ,  Takaharu Tanaka

    发明人： Naoki Higuchi ,  Masayuki Saitoh ,  Masaki Hashimoto ,  Harukazu Fukami ,  Takaharu Tanaka

    IPC分类号： C07D207/16 ,  C07D295/185

    CPC分类号： C07D295/185 ,  C07D207/16

    摘要： A compound of the general formula: ##STR1## wherein m is an integer of 1 to 7,n is 0 or an integer of 1 to 5,R.sup.1 is the phenyl, a substituted phenyl, the phenoxy, a substituted phenoxy or a saturated or unsaturated straight alkyl having 5 to 18 carbon atoms,R.sup.2 is hydrogen atom,R.sup.3 is hydrogen atom, a branched or unbranched alkyl having 3 to 5 carbon atoms, the phenyl, hydroxyphenyl, benzyloxyphenyl, an alkylthio having 1 to 3 carbon atoms in its alkyl moiety, amino, carboxyl, hydroxy, benzyloxy, indolyl or imidazolyl, or R.sup.2 and R.sup.3 together form a single bond between the carbon atom and the nitrogen atom, and a pharmaceutical composition containing said compound are provided. The compound is effective in curing amnesia because of its anti-prolyl endopeptidase activity.

    摘要翻译： 一种通式如下的化合物：其中m为1〜7的整数，n为0或1〜5的整数，R 1为苯基，取代苯基，苯氧基，取代的苯氧基或 具有5至18个碳原子的饱和或不饱和直链烷基，R 2是氢原子，R 3是氢原子，具有3至5个碳原子的支链或非支链烷基，苯基，羟基苯基，苄氧基苯基，具有1至3个碳原子的烷硫基 在其烷基部分中，氨基，羧基，羟基，苄氧基，吲哚基或咪唑基，或R2和R3一起形成碳原子和氮原子之间的单键，并提供含有所述化合物的药物组合物。 该化合物由于其抗脯氨酰内肽酶活性而有效地治愈健忘症。

    Cut flower preservative slurry composition
    4.
    发明授权
    Cut flower preservative slurry composition 失效
    切花防腐浆料组成

    公开(公告)号：US5961886A

    公开(公告)日：1999-10-05

    申请号：US634722

    申请日：1996-04-19

    申请人： Masaki Hashimoto ,  Takaharu Tanaka

    发明人： Masaki Hashimoto ,  Takaharu Tanaka

    IPC分类号： A01N3/02 ,  C09K15/32

    CPC分类号： A01N3/02

    摘要： A cut flower preservative slurry composition comprising a water insoluble or hardly soluble cut flower preservative component and a dispersing agent for dispersing the preservative component in water to form a slurry.

    摘要翻译： 一种切花防腐浆料组合物，其包含水不溶性或难溶性切花防腐剂组分和用于将防腐剂组分分散在水中以形成浆料的分散剂。

    Pyrrolidineamide derivative of acylamino acid and pharmaceutical containing the same
    8.
    发明授权
    Pyrrolidineamide derivative of acylamino acid and pharmaceutical containing the same 失效
    酰基氨基酸的吡咯烷酰胺衍生物和含有它们的药物

    公开(公告)号：US4826870A

    公开(公告)日：1989-05-02

    申请号：US10490

    申请日：1987-02-03

    申请人： Naoki Higuchi ,  Masayuki Saitoh ,  Masaki Hashimoto ,  Harukazu Fukami ,  Takaharu Tanaka

    发明人： Naoki Higuchi ,  Masayuki Saitoh ,  Masaki Hashimoto ,  Harukazu Fukami ,  Takaharu Tanaka

    IPC分类号： C07D207/16 ,  C07D295/185 ,  A61K31/40 ,  C07D207/09

    CPC分类号： C07D295/185 ,  C07D207/16

    摘要： A compound of the general formula: ##STR1## wherein m is an integer of 1 to 7, n is 0 or an integer of 1 to 5,R.sup.1 is the phenyl, a substituted phenyl, the phenoxy, a substituted phenoxy or a saturated or unsaturated straight alkyl having 5 to 18 carbon atoms,R.sup.2 is hydrogen atom,R.sup.3 is hydrogen atom, a branched or unbranched alkyl having 3 to 5 carbon atoms, the phenyl, hydroxyphenyl, benzyloxyphenyl, an alkylthio having 1 to 3 carbon atoms in its alkyl moiety, amino, carboxyl, hydroxy, benzyloxy, indolyl or imidazolyl, or R.sup.2 and R.sup.3 together form a single bond between the carbon atom and the nitrogen atom, and a pharmaceutical composition containing said compound are provided. The compound is effective in curing amnesia because of its anti-prolyl endopeptidase activity.

    摘要翻译： 一种通式如下的化合物：其中m为1〜7的整数，n为0或1〜5的整数，R 1为苯基，取代苯基，苯氧基，取代的苯氧基或 具有5至18个碳原子的饱和或不饱和直链烷基，R 2是氢原子，R 3是氢原子，具有3至5个碳原子的支链或非支链烷基，苯基，羟基苯基，苄氧基苯基，具有1至3个碳原子的烷硫基 在其烷基部分中，氨基，羧基，羟基，苄氧基，吲哚基或咪唑基，或R2和R3一起形成碳原子和氮原子之间的单键，并提供含有所述化合物的药物组合物。 该化合物由于其抗脯氨酰内肽酶活性而有效地治愈健忘症。