公开(公告)号：US20140196554A1

公开(公告)日：2014-07-17

申请号：US14232036

申请日：2012-06-28

申请人： Masanari Kato ,  Koji Nakamura

发明人： Masanari Kato ,  Koji Nakamura

IPC分类号： F16H19/08

CPC分类号： F16H19/08 ,  F16H1/32 ,  F16H2001/323 ,  Y10T74/188

摘要： Provided is a gear device capable of resolving inconveniences such as abnormal wear that arises due to the relative misalignment between the internal gear pins and the external gear, and inhibiting an increase in the number of components. This gear device has an outer cylinder, internal gear pins, and a carrier. A plurality of pin grooves extending in the axial direction of the outer cylinder are formed on the inner peripheral face of the outer cylinder, and the internal gear pins are fitted in the pin grooves. The pin grooves are formed so that the length of the pin grooves becomes longer than the length of the internal gear pins. The carrier has a pair of pressing members which includes a pressing surface. The pressing surface is configured to regulate movement of the internal gear pins and an oscillating gear which includes external teeth in the axial direction.

摘要翻译： 提供一种能够解决由于内齿轮销和外齿轮之间的相对不对中而引起的异常磨损等不良情况的齿轮装置，并且抑制部件数量的增加。 该齿轮装置具有外筒，内齿轮销和托架。 在外筒的内周面上形成有沿外筒的轴向延伸的多个销槽，并且内齿轮销嵌合在销槽中。 销槽形成为使得销槽的长度长于内齿轮销的长度。 载体具有包括按压面的一对按压部件。 按压面被构造成调节内齿轮的运动和在轴向上包括外齿的摆动齿轮。

公开(公告)号：US08900084B2

公开(公告)日：2014-12-02

申请号：US14232036

申请日：2012-06-28

申请人： Masanari Kato ,  Koji Nakamura

发明人： Masanari Kato ,  Koji Nakamura

IPC分类号： F16H1/32 ,  F16H19/08

CPC分类号： F16H19/08 ,  F16H1/32 ,  F16H2001/323 ,  Y10T74/188

摘要： Provided is a gear device capable of resolving inconveniences such as abnormal wear that arises due to the relative misalignment between the internal gear pins and the external gear, and inhibiting an increase in the number of components. This gear device has an outer cylinder, internal gear pins, and a carrier. A plurality of pin grooves extending in the axial direction of the outer cylinder are formed on the inner peripheral face of the outer cylinder, and the internal gear pins are fitted in the pin grooves. The pin grooves are formed so that the length of the pin grooves becomes longer than the length of the internal gear pins. The carrier has a pair of pressing members which includes a pressing surface. The pressing surface is configured to regulate movement of the internal gear pins and an oscillating gear which includes external teeth in the axial direction.

摘要翻译： 提供一种能够解决由于内齿轮销和外齿轮之间的相对不对中而引起的异常磨损等不良情况的齿轮装置，并且抑制部件数量的增加。 该齿轮装置具有外筒，内齿轮销和托架。 在外筒的内周面上形成有沿外筒的轴向延伸的多个销槽，并且内齿轮销嵌合在销槽中。 销槽形成为使得销槽的长度长于内齿轮销的长度。 载体具有包括按压面的一对按压部件。 按压面被构造成调节内齿轮的运动和在轴向上包括外齿的摆动齿轮。

公开(公告)号：US08956589B2

公开(公告)日：2015-02-17

申请号：US13203589

申请日：2010-02-26

申请人： Ikuo Tooyama ,  Hiroyasu Taguchi ,  Shigehiro Morikawa ,  Makoto Urushitani ,  Daijiro Yanagisawa ,  Tomone Nagae ,  Nobuaki Shirai ,  Koichi Hirao ,  Masanari Kato ,  Hirohiko Kimura ,  Takashi Okada

发明人： Ikuo Tooyama ,  Hiroyasu Taguchi ,  Shigehiro Morikawa ,  Makoto Urushitani ,  Daijiro Yanagisawa ,  Tomone Nagae ,  Nobuaki Shirai ,  Koichi Hirao ,  Masanari Kato ,  Hirohiko Kimura ,  Takashi Okada

IPC分类号： A61K49/06 ,  C07C69/738 ,  A61K31/12 ,  G01N33/68 ,  A61K49/10 ,  A61K51/04 ,  C07C49/255 ,  C07C59/70 ,  C07C59/90 ,  C07C225/22 ,  C07C235/78 ,  C07C255/40 ,  C07D213/50 ,  C07D307/46

CPC分类号： G01N33/6896 ,  A61K49/10 ,  A61K51/04 ,  C07C49/255 ,  C07C59/70 ,  C07C59/90 ,  C07C69/738 ,  C07C225/22 ,  C07C235/78 ,  C07C255/40 ,  C07D213/50 ,  C07D307/46 ,  G01N33/6839 ,  G01N2800/2821

摘要： Disclosed are a curcumin derivative or a salt thereof, which contains a fluorine atom, represented by formula (I): (wherein R1a and R1b are each independently a hydrogen atom, alkyl, acetyl, or methoxycarbonyl; R2s are each independently a fluorine atom, CHF2—, CF3—, CHF2O—, or CF3O—; R3s are each independently a hydrogen atom or a fluorine atom; A is alkyl, cyano, carboxyl, alkoxycarbonyl, or R4—(CH2)m—; R4 is hydroxy, carboxy, cyano, acetyloxy, alkoxycarbonyl, alkoxyalkoxy, hydroxyalkoxy, or CONR5R6; R5 and R6 are each independently a hydrogen atom or alkyl; and m is an integer from 1 to 5), and a diagnostic imaging agent for diagnosing a disease in which an amyloid β peptide aggregate accumulates, the diagnostic imaging agent containing a compound having a 1,3-dicarbonyl structure, wherein the compound exists in a keto form and an enol form, and the keto form and the enol form have different affinities, respectively, to the amyloid β peptide aggregate.

摘要翻译： 公开了含有由式（I）表示的氟原子的姜黄素衍生物或其盐：其中R 1a和R 1b各自独立地为氢原子，烷基，乙酰基或甲氧基羰基; R 2各自独立地为氟原子， CH 2 - ，CF 3 - ，CHF 2 O-或CF 3 O-; R 3各自独立地为氢原子或氟原子; A为烷基，氰基，羧基，烷氧基羰基或R 4 - （CH 2）m - ; R 4为羟基， 氰基，乙酰氧基，烷氧基羰基，烷氧基烷氧基，羟基烷氧基或CONR5R6; R5和R6各自独立地为氢原子或烷基; m为1至5的整数），以及用于诊断淀粉样蛋白和bgr的疾病的诊断显像剂 ; 肽聚集体积累，诊断成像剂含有具有1,3-二羰基结构的化合物，其中化合物以酮形式和烯醇形式存在，酮形式和烯醇形式分别具有与淀粉样蛋白不同的亲和力 ＆bgr 肽聚集体。

公开(公告)号：US08281048B2

公开(公告)日：2012-10-02

申请号：US12776696

申请日：2010-05-10

申请人： Daisuke Fujii ,  Masanari Kato

发明人： Daisuke Fujii ,  Masanari Kato

IPC分类号： G06F3/00

CPC分类号： G06F13/4081 ,  G06F2213/0042

摘要： An information processing apparatus includes a connector that conforms to a Universal Serial Bus standard. The information processing apparatus detects voltages at signal terminals of the connector a plurality of times, and judges a type of an apparatus connected to the connector by using detection results obtained the plurality of times.

摘要翻译： 信息处理装置包括符合通用串行总线标准的连接器。 信息处理装置多次检测连接器的信号端子处的电压，并且通过使用多次获得的检测结果来判断连接到连接器的装置的类型。

公开(公告)号：US5519119A

公开(公告)日：1996-05-21

申请号：US994469

申请日：1992-12-21

申请人： Nobutoshi Yamada ,  Masanari Kato ,  Keizo Miyata ,  Yoshiyuki Aoyama ,  Hiroshi Shikama

发明人： Nobutoshi Yamada ,  Masanari Kato ,  Keizo Miyata ,  Yoshiyuki Aoyama ,  Hiroshi Shikama

IPC分类号： A61K38/00 ,  C07K14/525 ,  C12N15/00 ,  A61K38/19 ,  C12N15/09

CPC分类号： C07K14/525 ,  A61K38/00

摘要： A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of Arg-Gly-Asp and from 3 to 16 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.

摘要翻译： 作为序列表中SEQ ID NO：1所示的具有由第1至第155位的Leu所表示的氨基酸序列的肿瘤坏死因子多肽的多肽或其突变蛋白，其中，第1位序列的氨基酸序列 至SEQ ID NO：1的第8位Asp或突变蛋白的相应氨基酸序列被含有至少一个Arg-Gly-Asp氨基酸序列和3至16个氨基酸的氨基酸序列替代。 还公开了含有编码这种多肽的DNA，由这样的重组质粒转化的重组微生物细胞的重组质粒，产生多肽的方法，包含多肽作为活性成分的药物组合物和多肽的DNA。

公开(公告)号：US20110311444A1

公开(公告)日：2011-12-22

申请号：US13203589

申请日：2010-02-26

申请人： Ikuo Tooyama ,  Hiroyasu Taguchi ,  Shigehiro Morikawa ,  Makoto Urushitani ,  Daijiro Yanagisawa ,  Tomone Nagae ,  Nobuaki Shirai ,  Koichi Hirao ,  Masanari Kato ,  Hirohiko Kimura ,  Takashi Okada

发明人： Ikuo Tooyama ,  Hiroyasu Taguchi ,  Shigehiro Morikawa ,  Makoto Urushitani ,  Daijiro Yanagisawa ,  Tomone Nagae ,  Nobuaki Shirai ,  Koichi Hirao ,  Masanari Kato ,  Hirohiko Kimura ,  Takashi Okada

IPC分类号： A61K49/06 ,  C07C69/738 ,  A61P43/00 ,  C07C49/255 ,  C07D309/32 ,  A61K49/00 ,  G01N21/64 ,  C07C59/90

CPC分类号： G01N33/6896 ,  A61K49/10 ,  A61K51/04 ,  C07C49/255 ,  C07C59/70 ,  C07C59/90 ,  C07C69/738 ,  C07C225/22 ,  C07C235/78 ,  C07C255/40 ,  C07D213/50 ,  C07D307/46 ,  G01N33/6839 ,  G01N2800/2821

摘要： Disclosed are a curcumin derivative or a salt thereof, which contains a fluorine atom, represented by formula (I): (wherein R1a and R1b are each independently a hydrogen atom, alkyl, acetyl, or methoxycarbonyl; R2s are each independently a fluorine atom, CHF2—, CF3—, CHF2O—, or CF3O—; R3s are each independently a hydrogen atom or a fluorine atom; A is alkyl, cyano, carboxyl, alkoxycarbonyl, or R4—(CH2)m—; R4 is hydroxy, carboxy, cyano, acetyloxy, alkoxycarbonyl, alkoxyalkoxy, hydroxyalkoxy, or CONR5R6; R5 and R6 are each independently a hydrogen atom or alkyl; and m is an integer from 1 to 5), and a diagnostic imaging agent for diagnosing a disease in which an amyloid β peptide aggregate accumulates, the diagnostic imaging agent containing a compound having a 1,3-dicarbonyl structure, wherein the compound exists in a keto form and an enol form, and the keto form and the enol form have different affinities, respectively, to the amyloid β peptide aggregate.

摘要翻译： 公开了含有由式（I）表示的氟原子的姜黄素衍生物或其盐：其中R 1a和R 1b各自独立地为氢原子，烷基，乙酰基或甲氧基羰基; R 2各自独立地为氟原子， CH 2 - ，CF 3 - ，CHF 2 O-或CF 3 O-; R 3各自独立地为氢原子或氟原子; A为烷基，氰基，羧基，烷氧基羰基或R 4 - （CH 2）m - ; R 4为羟基， 氰基，乙酰氧基，烷氧基羰基，烷氧基烷氧基，羟基烷氧基或CONR5R6; R5和R6各自独立地为氢原子或烷基; m为1至5的整数），以及用于诊断淀粉样蛋白和bgr的疾病的诊断显像剂 ; 肽聚集体积累，诊断成像剂含有具有1,3-二羰基结构的化合物，其中化合物以酮形式和烯醇形式存在，酮形式和烯醇形式分别具有与淀粉样蛋白不同的亲和力 ＆bgr 肽聚集体。

公开(公告)号：US20100293302A1

公开(公告)日：2010-11-18

申请号：US12776696

申请日：2010-05-10

申请人： Daisuke Fujii ,  Masanari Kato

发明人： Daisuke Fujii ,  Masanari Kato

IPC分类号： G06F13/00

CPC分类号： G06F13/4081 ,  G06F2213/0042

摘要： An information processing apparatus includes a connector that conforms to a Universal Serial Bus standard. The information processing apparatus detects voltages at signal terminals of the connector a plurality of times, and judges a type of an apparatus connected to the connector by using detection results obtained the plurality of times.

摘要翻译： 信息处理装置包括符合通用串行总线标准的连接器。 信息处理装置多次检测连接器的信号端子处的电压，并且通过使用多次获得的检测结果来判断连接到连接器的装置的类型。

公开(公告)号：US5247070A

公开(公告)日：1993-09-21

申请号：US763512

申请日：1991-09-20

申请人： Nobutoshi Yamada ,  Masanari Kato ,  Keizo Miyata ,  Yoshiyuki Aoyama ,  Hiroshi Shikama

发明人： Nobutoshi Yamada ,  Masanari Kato ,  Keizo Miyata ,  Yoshiyuki Aoyama ,  Hiroshi Shikama

IPC分类号： A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12N1/21 ,  C12N15/28 ,  C12P21/02 ,  C12R1/19

CPC分类号： C07K14/525 ,  C07K14/78 ,  A61K38/00 ,  C07K2319/00 ,  Y10S930/144

摘要： A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of cell-adherent peptide of laminin and from 5 to 30 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.