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    Cyclohexanedione derivative for hepatic disorders and a process for producing the same
    4.
    发明授权
    Cyclohexanedione derivative for hepatic disorders and a process for producing the same 失效
    肝脏疾病的环己二酮衍生物及其制备方法

    公开(公告)号：US4863925A

    公开(公告)日：1989-09-05

    申请号：US99898

    申请日：1987-09-22

    申请人： Shuhei Kubota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida

    发明人： Shuhei Kubota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida

    IPC分类号： A61K31/495 ,  A61P1/16 ,  C07D495/04

    CPC分类号： C07D495/04

    摘要： A cyclohexanedione derivative represented by the general formula (I); ##STR1## wherein R.sup.1, R.sup.4 and R.sup.7 represent independently hydrogen atom or C.sub.1 -C.sub.8 alkyl group, R.sup.2 represents hydrogen atom; C.sub.1 -C.sub.8 alkyl group; C.sub.2 -C.sub.6 alkenyl group; C.sub.3 -C.sub.8 cycloalkyl group; C.sub.2 -C.sub.7 alkoxycarbonyl group; C.sub.1 -C.sub.6 alkylthio C.sub.1 -C.sub.6 alkyl group; a phenyl group; a phenyl group substituted with 1 to 3 groups selected from the group consisting of halogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 haloalkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.6 alkylthio group, C.sub.3 -C.sub.8 cycloalkoxy group, a benzyloxy group and a benzyloxy group substituted with C.sub.1 -C.sub.6 alkoxy group; naphthyl group or a heterocyclic group, R.sup.3 represents hydrogen atom, C.sub.1 -C.sub.8 alkyl group or C.sub.2 -C.sub.7 alkoxycarbonyl group, and R.sup.5 and R.sup.6, which may be the same or different, represent hydrogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.6 alkenyl group, C.sub.2 -C.sub.7 alkylcarbonyl group or C.sub.2 -C.sub.7 haloalkylcarbonyl group or its pharmaceutically acceptable salts; a pharmaceutical composition containing the same that treats hepatic disorders; and a process for producing the same.

    Malonic acid derivatives
    5.
    发明授权
    Malonic acid derivatives 失效
    丙二酸衍生物

    公开(公告)号：US4835153A

    公开(公告)日：1989-05-30

    申请号：US90494

    申请日：1987-08-28

    申请人： Shuhei Kabota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida ,  Kuniaki Taninaka

    发明人： Shuhei Kabota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida ,  Kuniaki Taninaka

    IPC分类号： A61K31/495 ,  A61P1/16 ,  C07D495/04

    CPC分类号： C07D495/04

    摘要： This invention relates to a malonic acid derivative represented by the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, represents hydrogen atom; C.sub.1 -C.sub.12 alkyl group; C.sub.1 -C.sub.8 alkyl group substituted with C.sub.1 -C.sub.5 alkoxy group, a tetrahydrofuryl group, a phenyl group or a phenyl group substituted with 1 to 3 groups selected from the group consisting of halogen atoms, C.sub.1 -C.sub.5 alkyl groups and C.sub.1 -C.sub.5 alkoxy groups; or C.sub.2 -C.sub.6 alkenyl group; R.sup.3 and R.sup.4, which may be the same or different, represent hydrogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.6 alkenyl group, C.sub.2 -C.sub.8 alkoxyalkyl group, benzoyl group, C.sub.2 -C.sub.8 alkylcarbonyl group, C.sub.2 -C.sub.8 alkoxycarbonyl group, C.sub.1 -C.sub.4 alkylsulfonyl group or aralkyl group including benzyl group, and R.sup.5, R.sup.6 and R.sup.7, which may be the same or different, represent hydrogen atom or C.sub.1 -C.sub.4 alkyl group, and its pharmaceutically acceptable salts, a process for producing the same and a pharmaceutical composition containing the same.

    Dithiolane derivatives
    6.
    发明授权
    Dithiolane derivatives 失效
    二硫戊环衍生物

    公开(公告)号：US5041440A

    公开(公告)日：1991-08-20

    申请号：US396665

    申请日：1989-08-22

    申请人： Shuhei Kubota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida

    发明人： Shuhei Kubota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida

    IPC分类号： A61K31/385 ,  A61K31/495 ,  A61K31/535 ,  A61P1/16 ,  C07D339/06

    CPC分类号： C07D339/06

    摘要： Novel dithiolane derivatives of formula: ##STR1## wherein X is, a C.sub.2 -C.sub.7 alkylcarbonyl group, benzoyl group, benzoyl group substituted with 1-3 groups selected from halogen, C.sub.1 -C.sub.4 alkyl, and C.sub.1 -C.sub.4 alkoxy; Y represents C.sub.2 -C.sub.7 alkylcarbonyl group, C.sub.2 -C.sub.7 alkoxycarbonyl group or cyano group; and R represents di (C.sub.1 -C.sub.4 alkylamino) group, morpholino group or piperidino group, are produced by reacting glyoxal sodium bisulfite adduct with amine compounds in the presence of acids and then with dithiolates. The dithiolane derivatives can activate liver functions and are effective for treatment and prophylaxis of hepatitis and other hepatic disorders.

    摘要翻译： 新型的二硫戊环衍生物：其中X为C2-C7烷基羰基，苯甲酰基，被1-3个选自卤素，C1-C4烷基和C1-C4烷氧基的基取代的苯甲酰基; Y表示C2-C7烷基羰基，C2-C7烷氧基羰基或氰基; 并且R表示二（C1-C4烷基氨基）基，吗啉代基或哌啶子基，是通过使乙二醛亚硫酸氢钠加合物与胺化合物在酸存在下反应，然后与二硫醇盐反应来制备的。 二硫戊环衍生物可以激活肝功能，对于治疗和预防肝炎和其他肝脏疾病是有效的。

    Antimycotic agent and fungicidal agent
    7.
    发明授权
    Antimycotic agent and fungicidal agent 失效
    抗真菌剂和杀真菌剂

    公开(公告)号：US4738976A

    公开(公告)日：1988-04-19

    申请号：US916653

    申请日：1986-10-08

    申请人： Akira Seo ,  Hideo Kanno ,  Nobu Hasegawa ,  Yukio Miyagi ,  Akira Nishimura ,  Shigeo Konaka ,  Tetsuto Ohmi ,  Yukimi Munechika ,  Matazaemon Uchida ,  Kenichi Ikeda

    发明人： Akira Seo ,  Hideo Kanno ,  Nobu Hasegawa ,  Yukio Miyagi ,  Akira Nishimura ,  Shigeo Konaka ,  Tetsuto Ohmi ,  Yukimi Munechika ,  Matazaemon Uchida ,  Kenichi Ikeda

    IPC分类号： C07D521/00 ,  A01N43/40 ,  A01N43/50

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： A novel ketene S,S-acetal derivative which is useful as an antimycotic agent and an agricultural chemical of fungicidal, plant growth regulating or insecticidal properties represented by the general formula (I): ##STR1## wherein R represents a hydrogen atom; an alkyl group having 1 to 8 carbon atoms; a cycloalkyl group having 3 to 6 carbon atoms; a methylene group; a lower alkenyl group; a lower alkyl group substituted by a halogen atom, a cyano group, a lower alkoxyl group, a lower alkylthio group; a carbamoyl group, an acyl group, or an alkenoyloxy group; a phenyl group represented by ##STR2## (in which R.sub.1 represents a hydrogen atom, a halogen atom, a straight or branched chain lower alkyl group, a lower alkoxyl group which may be substituted by one or more halogen atoms, a phenoxy group or a methylenedioxy group, and m represents an integer of 1 to 3); a benzyl group; a methylenedioxybenzyl group; a phenoxyalkyl group; a phenoxyalkyl group substituted by a halogen atom; a naphthyl group; or a substituted or unsubstituted pyridyl group.

    摘要翻译： 可用作抗真菌剂的新颖的乙烯酮S，S-缩醛衍生物和由通式（I）表示的杀真菌剂，植物生长调节剂或杀虫剂性质的农业化学品：其中R表示氢原子 ; 具有1至8个碳原子的烷基; 具有3至6个碳原子的环烷基; 亚甲基; 低级烯基; 被卤素原子取代的低级烷基，氰基，低级烷氧基，低级烷硫基， 氨基甲酰基，酰基或烯酰基氧基; 由下式表示的苯基（其中R1表示氢原子，卤原子，直链或支链低级烷基，可被一个或多个卤素原子取代的低级烷氧基，苯氧基或 亚甲二氧基，m表示1〜3的整数）。 苄基; 亚甲二氧基苄基; 苯氧基烷基; 被卤素原子取代的苯氧基烷基; 萘基; 或取代或未取代的吡啶基。

    Ketene S,S-acetal derivative, a process for manufacturing thereof and a method for curing mycosis by administering it
    8.
    发明授权
    Ketene S,S-acetal derivative, a process for manufacturing thereof and a method for curing mycosis by administering it 失效
    氯乙烯S，S-缩醛衍生物，其制造方法和通过施用它来治愈真菌病的方法

    公开(公告)号：US4636519A

    公开(公告)日：1987-01-13

    申请号：US786123

    申请日：1985-10-10

    申请人： Akira Seo ,  Hideo Kanno ,  Nobu Hasegawa ,  Yukio Miyagi ,  Akira Nishimura ,  Shigeo Konaka ,  Tetsuto Ohmi ,  Yukimi Munechika ,  Matazaemon Uchida ,  Kenichi Ikeda

    发明人： Akira Seo ,  Hideo Kanno ,  Nobu Hasegawa ,  Yukio Miyagi ,  Akira Nishimura ,  Shigeo Konaka ,  Tetsuto Ohmi ,  Yukimi Munechika ,  Matazaemon Uchida ,  Kenichi Ikeda

    IPC分类号： A01N43/50 ,  C07D409/06 ,  C07D409/14 ,  C07D521/00 ,  A61K31/415 ,  A61K31/44 ,  C07D401/00 ,  C07D403/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： A novel ketene S,S-acetal derivative which is useful as an antimycotic agent and an agricultural chemical of fungicidal, plant growth regulating or insecticidal properties represented by the general formula (I): ##STR1## wherein R represents a hydrogen atom; an alkyl group having 1 to 8 carbon atoms; a cycloalkyl group having 3 to 6 carbon atoms; a methylene group; a lower alkenyl group; a lower alkyl group substituted by a halogen atom, a cyano group, a lower alkoxy group, a lower alkylthio group; a carbamoyl group, an acyl group, or an alkenoyloxy group; a phenyl group represented by ##STR2## (in which R.sub.1 represents a hydrogen atom, a halogen atom, a straight or branched chain lower alkyl group, a lower alkoxyl group which may be substituted by one or more halogen atoms, a phenoxy group or a methylenedioxy group, and m represents an integer of 1 to 3); a benzyl group; a methylenedioxybenzyl group; a phenoxyalkyl group; a phenoxyalkyl group substituted by a halogen atom; a naphthyl group; or a substituted or unsubstituted pyridyl group.

    摘要翻译： 可用作抗真菌剂的新颖的乙烯酮S，S-缩醛衍生物和由通式（I）表示的杀真菌剂，植物生长调节剂或杀虫剂性质的农业化学品：其中R表示氢原子 ; 具有1至8个碳原子的烷基; 具有3至6个碳原子的环烷基; 亚甲基; 低级烯基; 被卤素原子取代的低级烷基，氰基，低级烷氧基，低级烷硫基; 氨基甲酰基，酰基或烯酰基氧基; 由下式表示的苯基（其中R1表示氢原子，卤原子，直链或支链低级烷基，可被一个或多个卤素原子取代的低级烷氧基，苯氧基或 亚甲二氧基，m表示1〜3的整数）。 苄基; 亚甲二氧基苄基; 苯氧基烷基; 被卤素原子取代的苯氧基烷基; 萘基; 或取代或未取代的吡啶基。