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11 条记录 (耗时 0.02 秒)

    Cyclohexanedione derivative for hepatic disorders and a process for producing the same
    4.
    发明授权
    Cyclohexanedione derivative for hepatic disorders and a process for producing the same 失效
    肝脏疾病的环己二酮衍生物及其制备方法

    公开(公告)号：US4863925A

    公开(公告)日：1989-09-05

    申请号：US99898

    申请日：1987-09-22

    申请人： Shuhei Kubota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida

    发明人： Shuhei Kubota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida

    IPC分类号： A61K31/495 ,  A61P1/16 ,  C07D495/04

    CPC分类号： C07D495/04

    摘要： A cyclohexanedione derivative represented by the general formula (I); ##STR1## wherein R.sup.1, R.sup.4 and R.sup.7 represent independently hydrogen atom or C.sub.1 -C.sub.8 alkyl group, R.sup.2 represents hydrogen atom; C.sub.1 -C.sub.8 alkyl group; C.sub.2 -C.sub.6 alkenyl group; C.sub.3 -C.sub.8 cycloalkyl group; C.sub.2 -C.sub.7 alkoxycarbonyl group; C.sub.1 -C.sub.6 alkylthio C.sub.1 -C.sub.6 alkyl group; a phenyl group; a phenyl group substituted with 1 to 3 groups selected from the group consisting of halogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 haloalkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.6 alkylthio group, C.sub.3 -C.sub.8 cycloalkoxy group, a benzyloxy group and a benzyloxy group substituted with C.sub.1 -C.sub.6 alkoxy group; naphthyl group or a heterocyclic group, R.sup.3 represents hydrogen atom, C.sub.1 -C.sub.8 alkyl group or C.sub.2 -C.sub.7 alkoxycarbonyl group, and R.sup.5 and R.sup.6, which may be the same or different, represent hydrogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.6 alkenyl group, C.sub.2 -C.sub.7 alkylcarbonyl group or C.sub.2 -C.sub.7 haloalkylcarbonyl group or its pharmaceutically acceptable salts; a pharmaceutical composition containing the same that treats hepatic disorders; and a process for producing the same.

    Malonic acid derivatives
    5.
    发明授权
    Malonic acid derivatives 失效
    丙二酸衍生物

    公开(公告)号：US4835153A

    公开(公告)日：1989-05-30

    申请号：US90494

    申请日：1987-08-28

    申请人： Shuhei Kabota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida ,  Kuniaki Taninaka

    发明人： Shuhei Kabota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida ,  Kuniaki Taninaka

    IPC分类号： A61K31/495 ,  A61P1/16 ,  C07D495/04

    CPC分类号： C07D495/04

    摘要： This invention relates to a malonic acid derivative represented by the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, represents hydrogen atom; C.sub.1 -C.sub.12 alkyl group; C.sub.1 -C.sub.8 alkyl group substituted with C.sub.1 -C.sub.5 alkoxy group, a tetrahydrofuryl group, a phenyl group or a phenyl group substituted with 1 to 3 groups selected from the group consisting of halogen atoms, C.sub.1 -C.sub.5 alkyl groups and C.sub.1 -C.sub.5 alkoxy groups; or C.sub.2 -C.sub.6 alkenyl group; R.sup.3 and R.sup.4, which may be the same or different, represent hydrogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.6 alkenyl group, C.sub.2 -C.sub.8 alkoxyalkyl group, benzoyl group, C.sub.2 -C.sub.8 alkylcarbonyl group, C.sub.2 -C.sub.8 alkoxycarbonyl group, C.sub.1 -C.sub.4 alkylsulfonyl group or aralkyl group including benzyl group, and R.sup.5, R.sup.6 and R.sup.7, which may be the same or different, represent hydrogen atom or C.sub.1 -C.sub.4 alkyl group, and its pharmaceutically acceptable salts, a process for producing the same and a pharmaceutical composition containing the same.

    Dithiolane derivatives
    6.
    发明授权
    Dithiolane derivatives 失效
    二硫戊环衍生物

    公开(公告)号：US5041440A

    公开(公告)日：1991-08-20

    申请号：US396665

    申请日：1989-08-22

    申请人： Shuhei Kubota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida

    发明人： Shuhei Kubota ,  Kunikazu Hiraga ,  Keisuke Nakayama ,  Matazaemon Uchida

    IPC分类号： A61K31/385 ,  A61K31/495 ,  A61K31/535 ,  A61P1/16 ,  C07D339/06

    CPC分类号： C07D339/06

    摘要： Novel dithiolane derivatives of formula: ##STR1## wherein X is, a C.sub.2 -C.sub.7 alkylcarbonyl group, benzoyl group, benzoyl group substituted with 1-3 groups selected from halogen, C.sub.1 -C.sub.4 alkyl, and C.sub.1 -C.sub.4 alkoxy; Y represents C.sub.2 -C.sub.7 alkylcarbonyl group, C.sub.2 -C.sub.7 alkoxycarbonyl group or cyano group; and R represents di (C.sub.1 -C.sub.4 alkylamino) group, morpholino group or piperidino group, are produced by reacting glyoxal sodium bisulfite adduct with amine compounds in the presence of acids and then with dithiolates. The dithiolane derivatives can activate liver functions and are effective for treatment and prophylaxis of hepatitis and other hepatic disorders.

    摘要翻译： 新型的二硫戊环衍生物：其中X为C2-C7烷基羰基，苯甲酰基，被1-3个选自卤素，C1-C4烷基和C1-C4烷氧基的基取代的苯甲酰基; Y表示C2-C7烷基羰基，C2-C7烷氧基羰基或氰基; 并且R表示二（C1-C4烷基氨基）基，吗啉代基或哌啶子基，是通过使乙二醛亚硫酸氢钠加合物与胺化合物在酸存在下反应，然后与二硫醇盐反应来制备的。 二硫戊环衍生物可以激活肝功能，对于治疗和预防肝炎和其他肝脏疾病是有效的。