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公开(公告)号：US07575915B2
公开(公告)日：2009-08-18
申请号：US10031988
申请日：2001-05-25
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/807
摘要： A biosensor is provided with a development layer for developing an inspection target solution, that has a reagent immobilization part where an antibody for a measurement target in the inspection target solution is immobilized and a reagent holding part which marks in a dry state and holds an antibody which can be eluted by development of the inspection target solution in parts of the development layer. The biosensor measures a bonding amount of the marker reagent bonded to the reagent immobilization part, thereby qualitatively or quantitatively measuring components to be measured in the inspection target solution, and is further provided with a space forming material that forms a cavity part, which is a space into which the inspection target solution flows, between the development layer for developing the inspection target solution and the space forming material.
摘要翻译： 生物传感器设置有用于开发检查对象溶液的显影层，其具有固定有检查对象溶液中的测定对象的抗体的试剂固定部以及标记为干燥状态并保持抗体的试剂保持部 其可以通过在显影层的部分中开发检查目标溶液而被洗脱。 生物传感器测定与试剂固定部接合的标记试剂的结合量，从而定量或定量地测量检查对象溶液中待测量的成分，并且还设置有空间形成材料，其形成空腔部分，其为 检查对象溶液流动的空间，用于显影检查对象溶液的显影层和空间形成材料之间。
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公开(公告)号：US07998752B2
公开(公告)日：2011-08-16
申请号：US11950706
申请日：2007-12-05
IPC分类号： G01N33/53
CPC分类号： G01N30/90 , G01N33/5002 , G01N33/5005 , G01N33/558 , Y10S436/808 , Y10S436/81
摘要： According to the biosensor and the blood component analytical method of the present invention, in a biosensor that is made of a single layer or plural layers of a porous material as shown in FIG. 1, having a reagent holding part and utilizing chromatography, a cell shrinkage reagent is carried on at least part of the reagent holding part, or at least part of a chromatographically developed part that is upstream of the reagent holding part. According to the biosensor having the above-mentioned structure and the blood component analytical method, even when whole blood is a sample, a high-accuracy blood component analysis cart be performed easily and quickly with less cost.
摘要翻译： 根据本发明的生物传感器和血液成分分析方法，在图1所示的由单层或多层多孔质材料构成的生物传感器中， 如图1所示，具有试剂保持部并利用色谱法，在试剂保持部的至少一部分或者在试剂保持部的上游的色谱显影部的至少一部分上承载有细胞收缩试剂。 根据具有上述结构的生物传感器和血液成分分析方法，即使全血是样品，也能够以更低的成本容易且快速地进行高精度的血液成分分析手推车。
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公开(公告)号：US07790439B2
公开(公告)日：2010-09-07
申请号：US10416272
申请日：2002-08-09
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： In a biosensor having a developing layer for developing a sample solution, including a reagent part immobilized to a portion of the developing layer and a marked reagent part which is held in a dry state by a portion of the developing layer, and is dissolvable by developing the sample solution, and qualitatively or quantitatively analyzing an analyte in the sample solution by measuring the amount of the marker reagent bound to the reagent immobilization part; wherein plural reagent immobilization parts exist, and the respective reagent immobilization parts have different affinities for the analyte in the sample solution or the marker reagent, whereby a prozone phenomenon can be detected. Further, a biosensor with a high precision of measurement, which has a wider dynamic range for the concentration of the analyte in the sample solution, can be provided. Thereby, a highly accurate and precise biosensor which can detect a prozone phenomenon even when the range of the concentration of the analyte in the sample solution is wide, and has a wide measurement dynamic range can be provided.
摘要翻译： 在具有用于显影样品溶液的显影层的生物传感器中，包括固定在显影层的一部分上的试剂部分和由显影层的一部分保持在干燥状态的标记的试剂部分，并且可通过显影 样品溶液，并通过测量与试剂固定部分结合的标记试剂的量定性或定量分析样品溶液中的分析物; 其中存在多个试剂固定部分，并且各试剂固定部分对于样品溶液或标记试剂中的分析物的亲和力不同，从而可以检测到前区现象。 此外，可以提供具有高测量精度的生物传感器，其具有用于样品溶液中的分析物浓度的更宽的动态范围。 因此，即使在样品溶液中的分析物的浓度范围宽的情况下也能够检测前区现象的高精度且精确的生物传感器，并且具有宽的测量动态范围。
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公开(公告)号：US20080085561A1
公开(公告)日：2008-04-10
申请号：US11950706
申请日：2007-12-05
CPC分类号： G01N30/90 , G01N33/5002 , G01N33/5005 , G01N33/558 , Y10S436/808 , Y10S436/81
摘要： According to the biosensor and the blood component analytical method of the present invention, in a biosensor that is made of a single layer or plural layers of a porous material as shown in FIG. 1, having a reagent holding part and utilizing chromatography, a cell shrinkage reagent is carried on at least part of the reagent holding part, or at least part of a chromatographically developed part that is upstream of the reagent holding part. According to the biosensor having the above-mentioned structure and the blood component analytical method, even when whole blood is a sample, a high-accuracy blood component analysis can be performed easily and quickly with less cost.
摘要翻译： 根据本发明的生物传感器和血液成分分析方法，在图1所示的由单层或多层多孔质材料构成的生物传感器中， 如图1所示，具有试剂保持部并利用色谱法，在试剂保持部的至少一部分或者在试剂保持部的上游的色谱显影部的至少一部分上承载有细胞收缩试剂。 根据具有上述结构和血液成分分析方法的生物传感器，即使全血是样品，也能够以较低的成本容易且快速地进行高精度的血液成分分析。
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公开(公告)号：US07112451B2
公开(公告)日：2006-09-26
申请号：US10069845
申请日：2001-06-28
IPC分类号： G01N33/53 , G01N21/00 , G01N33/543
CPC分类号： G01N33/558 , G01N33/54306 , G01N33/54386 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/81
摘要： A biosensor is provided with an area in which a reagent having bleaching action is carried in a state where it can be dissolved, at least in a part of a sample application area to which an inspection target solution is applied or the downstream of the sample application area in the direction of the inspection target solution permeating, in a development layer. In the so-constituted biosensor, a colored component in the inspection target solution can be faded by the bleaching reagent, so that the color in parts other than a reactive area is reduced in consequence, whereby a visual judgment is possible and a more accurate measurement result in which a reading error by a measuring device is extremely suppressed can be obtained.
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公开(公告)号：US07915051B2
公开(公告)日：2011-03-29
申请号：US11950671
申请日：2007-12-05
IPC分类号： G01N33/53
CPC分类号： G01N30/90 , G01N33/5002 , G01N33/5005 , G01N33/558 , Y10S436/808 , Y10S436/81
摘要： According to the biosensor and the blood component analytical method of the present invention, in a biosensor that is made of a single layer or plural layers of a porous material as shown in FIG. 1, having a reagent holding part and utilizing chromatography, a cell shrinkage reagent is carried on at least part of the reagent holding part, or at least part of a chromatographically developed part that is upstream of the reagent holding part. According to the biosensor having the above-mentioned structure and the blood component analytical method, even when whole blood is a sample, a high-accuracy blood component analysis cart be performed easily and quickly with less cost.
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公开(公告)号：US07598090B2
公开(公告)日：2009-10-06
申请号：US11492011
申请日：2006-07-24
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/54306 , G01N33/54386 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/81
摘要： A biosensor is provided with an area in which a reagent having bleaching action is carried in a state where it can be dissolved, at least in a part of a sample application area to which an inspection target solution is applied or the downstream of the sample application area in the direction of the inspection target solution permeating, in a development layer. In the so-constituted biosensor, a colored component in the inspection target solution can be faded by the bleaching reagent, so that the color in parts other than a reactive area is reduced in consequence, whereby a visual judgment is possible and a more accurate measurement result in which a reading error by a measuring device is extremely suppressed can be obtained.
摘要翻译： 生物传感器具有在其可以溶解状态下携带有漂白作用的试剂的区域，至少在施加检查对象溶液的样品施加区域的一部分或样品施加的下游 在检查对象溶液的方向上渗透在显影层中的区域。 在如此构成的生物传感器中，检查对象溶液中的有色成分可以被漂白试剂褪色，因此减少反应区域以外的部分的颜色，从而可以进行目视判断和更准确的测定 可以获得测量装置的读取误差被极度抑制的结果。
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公开(公告)号：US20080083619A1
公开(公告)日：2008-04-10
申请号：US11950671
申请日：2007-12-05
IPC分类号： C12Q1/00
CPC分类号： G01N30/90 , G01N33/5002 , G01N33/5005 , G01N33/558 , Y10S436/808 , Y10S436/81
摘要： According to the biosensor and the blood component analytical method of the present invention, in a biosensor that is made of a single layer or plural layers of a porous material as shown in FIG. 1, having a reagent holding part and utilizing chromatography, a cell shrinkage reagent is carried on at least part of the reagent holding part, or at least part of a chromatographically developed part that is upstream of the reagent holding part. According to the biosensor having the above-mentioned structure and the blood component analytical method, even when whole blood is a sample, a high-accuracy blood component analysis can be performed easily and quickly with less cost.
摘要翻译： 根据本发明的生物传感器和血液成分分析方法，在图1所示的由单层或多层多孔质材料构成的生物传感器中， 如图1所示，具有试剂保持部并利用色谱法，在试剂保持部的至少一部分或者在试剂保持部的上游的色谱显影部的至少一部分上承载有细胞收缩试剂。 根据具有上述结构和血液成分分析方法的生物传感器，即使全血是样品，也能够以较低的成本容易且快速地进行高精度的血液成分分析。
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公开(公告)号：US20060275921A1
公开(公告)日：2006-12-07
申请号：US11492011
申请日：2006-07-24
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N33/54306 , G01N33/54386 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/81
摘要： A biosensor is provided with an area in which a reagent having bleaching action is carried in a state where it can be dissolved, at least in a part of a sample application area to which an inspection target solution is applied or the downstream of the sample application area in the direction of the inspection target solution permeating, in a development layer. In the so-constituted biosensor, a colored component in the inspection target solution can be faded by the bleaching reagent, so that the color in parts other than a reactive area is reduced in consequence, whereby a visual judgment is possible and a more accurate measurement result in which a reading error by a measuring device is extremely suppressed can be obtained.
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公开(公告)号：US20080292502A1
公开(公告)日：2008-11-27
申请号：US11910513
申请日：2006-03-24
CPC分类号： B01F3/08 , B01F13/0059 , B01F15/0233 , B01F2215/0037 , G01N21/07 , G01N35/00069 , G01N2035/00495 , G01N2035/00524 , Y10T436/111666 , Y10T436/2575
摘要： Herein disclosed is a liquid homogenizer which can evenly mix liquids with small space.There is provided a liquid homogenizer for mixing two or more liquids, comprising: a rotator (1) rotatable around a rotation axis; at least two liquid-mixing chambers (6, 10) formed in the rotator, and being different from each other in distance from the rotation axis; and at least two channels (8) through which one of the liquid-mixing chambers is communicated with the other of the liquid-mixing chambers (6, 10), wherein the liquid-mixing chambers (6, 10) include an outer liquid-mixing chamber (10) and an inner liquid-mixing chamber (6) close to the rotation axis in comparison with the outer liquid-mixing chamber, when the rotator (1) is rotating around the rotation axis, the liquids are shifted by a centrifugal force to the outer liquid-mixing chamber from the inner liquid-mixing chamber through the channels (8), and agitated to be mixed by turbulent flows in the outer liquid-mixing chamber.
摘要翻译： 本文公开了一种液体均化器，其可以均匀地混合具有小空间的液体。 提供了一种用于混合两种或更多种液体的液体均化器，包括：可围绕旋转轴线旋转的旋转器（1）; 形成在旋转体中的至少两个液体混合室（6,10），并且与旋转轴线的距离彼此不同; 和至少两个通道（8），其中一个液体混合室通过该通道与另一个液体混合室（6,10）连通，其中液体混合室（6,10）包括外部液体 - 混合室（10）和与外部液体混合室相比靠近旋转轴线的内部混合室（6），当旋转体（1）围绕旋转轴线旋转时，液体被离心 通过通道（8）从内部液体混合室向外部液体混合室施力，并搅拌以在外部混合室中被湍流混合。
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