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公开(公告)号：US12117601B2
公开(公告)日：2024-10-15
申请号：US17972458
申请日：2022-10-24
申请人： Medica Corporation
发明人： Ronald Jones , Adrian Gropper , Robert Hagopian , Charles Rogers , Thomas Vitella , Donald Barry, Jr. , Dirk Osterloh , Chen Yi , Tyler Cote
IPC分类号： G01N15/1433 , B01L3/00 , B01L9/00 , G01N1/31 , G01N1/38 , G01N15/01 , G01N15/10 , G01N15/14 , G01N35/00 , G02B21/16 , G02B21/34
CPC分类号： G02B21/16 , B01L3/502715 , B01L9/527 , G01N1/312 , G01N1/38 , G01N15/1433 , G01N35/00069 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/021 , B01L2300/0654 , B01L2300/0867 , B01L2300/0883 , B01L2300/123 , B01L2300/161 , B01L2400/049 , B01L2400/0622 , B01L2400/0644 , B01L2400/0694 , G01N2015/012 , G01N2015/016 , G01N2015/1006 , G01N2015/1486 , G01N2035/00138 , G02B21/34
摘要： Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.
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公开(公告)号：US20240183870A1
公开(公告)日：2024-06-06
申请号：US18279438
申请日：2021-03-09
发明人： Sakiko NARIKAWA , Naomi ISHII , Megumi MIZUNO
CPC分类号： G01N35/00603 , G01N1/38 , G01N35/00069 , G01N2035/00168
摘要： An analysis device according to the present invention comprises: at least one inspection device that inspects a specimen; and at least one specimen production device that produces a specimen. The analysis device is provided with a data processing unit that processes data. The inspection device and the specimen production device are each provided with a communication unit for communicating with each other. The specimen production device is provided with a control unit that controls the specimen production device and a production unit that produces a specimen. The inspection device is provided with a control unit that controls the inspection device and an inspection unit that inspects a specimen. The data processing unit calculates a value [number of specimens A] representing the number of specimens which have not been delivered to the inspection device and a value [number of specimens B] representing the sum of the number of specimens for which inspection can be additionally started in the inspection device and the number of specimens which are being inspected and the inspection of which will be completed in a prescribed time. The control unit of the specimen production device prohibits production of a new specimen in the specimen production device when the [number of specimens A] and the [number of specimens B] satisfy a first relationship.
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公开(公告)号：US11806713B2
公开(公告)日：2023-11-07
申请号：US17537439
申请日：2021-11-29
申请人： Nexogen, Inc.
发明人： Dalibor Hodko , Nives Hodko , Anne-Laure Petit , Ulrich Niemann
CPC分类号： B01L3/502746 , B01L3/50273 , G01N35/00069 , B01L2200/16 , B01L2300/0645 , B01L2300/0819 , B01L2400/0415 , B01L2400/0463 , B01L2400/0487 , B01L2400/082
摘要： The invention relates to a microfluidic system based on active control of flow resistance and balancing pressures in microfluidic channels and an improved method for disposable microfluidic devices and cartridges for use in, but not limited to, in-vitro diagnostics. The microfluidic system and device of the invention does not utilize mechanical moving parts to control the fluid flow and has no external fluidic connection to the instrument or fluidics controller.
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公开(公告)号：US20230271199A1
公开(公告)日：2023-08-31
申请号：US18313639
申请日：2023-05-08
CPC分类号： B04B13/00 , B01L3/502715 , B01L3/50273 , B04B5/02 , G01N21/07 , G01N35/00069 , G01N35/04 , B01L2200/0647 , B01L2200/143 , B01L2300/0803 , B01L2400/0409 , G01N2035/0491 , G01N2201/06113 , G01N2201/1087
摘要： Provided are methods and apparatuses for controlling a position of a target point on a processing result relative to a focus point of a focusing sensor system for determining properties of the processing result. The method includes the steps of determining an initial focus point of the focusing sensor system, controlling rotation of the cartridge and disc, checking whether the initial focus point of the focusing sensor system corresponds to the target point on the processing result, comparing (x, y) target positions in captured images with the initial focus point of the focusing sensor system, adjusting rotation of the cartridge and disc such that the focus point of the focusing sensor system corresponds to the target point on the processing result, and detecting and examining signals received from the focusing sensor system for determining properties of the processing result.
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公开(公告)号：US20230185070A1
公开(公告)日：2023-06-15
申请号：US17972458
申请日：2022-10-24
申请人： Medica Corporation
发明人： Ronald Jones , Adrian Gropper , Robert Hagopian , Charles Rogers , Thomas Vitella , Donald Barry, JR. , Dirk Osterloh , Chen Yi , Tyler Cote
CPC分类号： G02B21/16 , G01N15/1463 , G01N1/312 , G01N1/38 , B01L3/502715 , G01N35/00069 , B01L9/527 , G02B21/34
摘要： Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.
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公开(公告)号：US20190233887A1
公开(公告)日：2019-08-01
申请号：US16225720
申请日：2018-12-19
发明人： Jon A. HOSHIZAKI , Joon Mo YANG , Maryam SHARIATI , David M. COX , Kirk M. HIRANO , John BRIDGHAM , George Stefan GOLDA , Sam Lee WOO
IPC分类号： C12Q1/6869 , G01N35/10 , B01F13/00 , B01F13/02 , B01J19/00 , C12Q1/6874 , B01L3/00 , G01N35/00
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
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公开(公告)号：US20180364270A1
公开(公告)日：2018-12-20
申请号：US15741462
申请日：2016-07-07
IPC分类号： G01N35/10 , G01N15/14 , G01N21/64 , G01N35/00 , G01N35/04 , G01N35/02 , C12Q1/686 , B01L3/00 , B01L7/00 , B01L9/00
CPC分类号： G01N35/1016 , B01L3/5025 , B01L3/502746 , B01L7/52 , B01L9/523 , B01L2200/027 , B01L2200/0673 , B01L2300/0809 , B01L2300/0816 , B01L2300/0864 , B01L2300/18 , B01L2300/1894 , B01L2400/0409 , C12Q1/686 , G01N15/1463 , G01N21/6456 , G01N35/00069 , G01N35/025 , G01N35/04 , G01N2015/1006 , G01N2035/00158 , G01N2035/00356 , G01N2035/00366 , G01N2035/0449 , G01N2035/1034
摘要： Systems, methods, and devices for discretizing and analyzing fluidic samples are provided. In one aspect, a microfluidic array for discretizing a fluidic sample comprises one or more flow channels and a plurality of fluidic compartments in fluidic communication with the one or more flow channels. In another aspect, a system for discretizing and analyzing fluidic samples comprises a rotor assembly shaped to receive a microfluidic device.
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公开(公告)号：US20180264471A1
公开(公告)日：2018-09-20
申请号：US15982009
申请日：2018-05-17
发明人： Christoph Boehm , Thorsten Brueckner , Thomas Fischer , Eloisa Lopez-Calle , Sascha Lutz , Josef Roedl , Juergen Spinke , Pamela Espindola , Thomas Manuel Keller , Thomas Dolbinow , Sabrina Adler , Erik Beiersdorf , Domenik Wensorra
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01L3/5023 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/16 , B01L2300/0627 , B01L2300/0803 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/084 , G01N35/00069 , G01N2035/1032
摘要： A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.
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公开(公告)号：US20180136243A1
公开(公告)日：2018-05-17
申请号：US15807802
申请日：2017-11-09
发明人： Christoph Boehm , Sascha Lutz , Thomas Keller
CPC分类号： G01N35/00584 , B01L3/5027 , B01L3/502753 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/0803 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , G01F13/00 , G01N33/5005 , G01N35/00 , G01N35/00069 , G01N35/1016 , G01N2035/00495
摘要： A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. Each metering chamber may comprise a sample inlet, a sample outlet, and a metered outlet for dispensing a predetermined volume. At least one sample distribution channel is connected between the sample outlet of a metering chamber with a sample inlet of another metering chamber. For each metering chamber, a connecting tube fluidically connects the sample inlet with the sample holding chamber, a microfluidic structure for processing the sample into a processed sample connects to the sample outlet, and a measurement structure fluidically connects to the microfluidic structure and enables measurement of the processed sample to determine the amount of the analyte in the processed sample.
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公开(公告)号：US20180133714A1
公开(公告)日：2018-05-17
申请号：US15323105
申请日：2015-07-02
CPC分类号： B01L3/502753 , B01L3/502715 , B01L3/50273 , B01L3/567 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/06 , B01L2300/0803 , B01L2300/0816 , B01L2300/0858 , B01L2300/0864 , B01L2400/0409 , B01L2400/0487 , B01L2400/0655 , G01N1/4077 , G01N33/491 , G01N35/00069 , G01N2001/4083
摘要： A sample processing kit including a centrifugal microfluidic component and a collection component detachably fitted into the microfluidic component is provided. Upon the application of the sample processing kit, target molecules or cells may be separated and collected by the collection component for further experimentation.
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