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公开(公告)号：US09090586B2
公开(公告)日：2015-07-28
申请号：US13813786
申请日：2011-08-03
申请人： Masato Yoshikawa , Shinkichi Suzuki , Tomoaki Hasui , Makoto Fushimi , Jun Kunitomo , Haruhi Kamisaki , Takahiko Taniguchi
发明人： Masato Yoshikawa , Shinkichi Suzuki , Tomoaki Hasui , Makoto Fushimi , Jun Kunitomo , Haruhi Kamisaki , Takahiko Taniguchi
IPC分类号： A61K31/553 , A61K31/525 , A61K31/535 , C07D401/00 , C07D498/02 , C07D413/00 , C07D241/00 , C07D413/14 , C07D498/08 , C07D417/14 , C07D403/14 , A61K9/20 , C07D403/04 , A61K9/00 , C07D401/14
CPC分类号： C07D403/04 , A61K9/00 , A61K9/2018 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D498/08
摘要： The present invention provides a compound represented by the formula (1): wherein each symbol is as defined in the specification, or a salt thereof, a prodrug of the compound or a salt thereof, a medicament containing the compound or a salt thereof, the medicament which is a phosphodiesterase 10A inhibitor, and a medicament which is for preventing or treating schizophrenia.
摘要翻译： 本发明提供由式（1）表示的化合物：其中各符号如说明书中所定义，或其盐，化合物或其盐的前药，含有该化合物或其盐的药物， 作为磷酸二酯酶10A抑制剂的药物，以及用于预防或治疗精神分裂症的药物。
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公开(公告)号：US20130150344A1
公开(公告)日：2013-06-13
申请号：US13813786
申请日：2011-08-03
申请人： Masato Yoshikawa , Shinkichi Suzuki , Tomoaki Hasui , Makoto Fushimi , Jun Kunitomo , Haruhi Kamisaki , Takahiko Taniguchi
发明人： Masato Yoshikawa , Shinkichi Suzuki , Tomoaki Hasui , Makoto Fushimi , Jun Kunitomo , Haruhi Kamisaki , Takahiko Taniguchi
IPC分类号： C07D403/04 , C07D417/14 , C07D413/14 , C07D401/14 , C07D403/14 , C07D498/08
CPC分类号： C07D403/04 , A61K9/00 , A61K9/2018 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D498/08
摘要： The present invention provides a compound represented by the formula (1): wherein each symbol is as defined in the specification, or a salt thereof, a prodrug of the compound or a salt thereof, a medicament containing the compound or a salt thereof, the medicament which is a phosphodiesterase 10A inhibitor, and a medicament which is for preventing or treating schizophrenia.
摘要翻译： 本发明提供由式（1）表示的化合物：其中各符号如说明书中所定义，或其盐，化合物或其盐的前药，含有该化合物或其盐的药物， 作为磷酸二酯酶10A抑制剂的药物，以及用于预防或治疗精神分裂症的药物。
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公开(公告)号：US20130137675A1
公开(公告)日：2013-05-30
申请号：US13816011
申请日：2011-08-09
申请人： Takahiko Taniguchi , Shinkichi Suzuki , Masato Yoshikawa , Tomoaki Hasui , Makoto Fushimi , Jun Kunitomo
发明人： Takahiko Taniguchi , Shinkichi Suzuki , Masato Yoshikawa , Tomoaki Hasui , Makoto Fushimi , Jun Kunitomo
IPC分类号： C07D498/04 , C07D405/04 , C07D403/04 , C07D409/14 , C07D401/14 , C07D405/14 , C07D409/04 , C07D413/14 , C07D491/048 , C07D401/04
CPC分类号： C07D498/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048
摘要： The present invention aims to provide a compound having a PDE inhibitory action and useful as a medicament for the prophylaxis or treatment of schizophrenia and the like.A compound represented by the formula (1x): wherein each symbol is as described in the DESCRIPTION, or the formula (1): W1—W2 (1) wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
摘要翻译： 本发明旨在提供具有PDE抑制作用并可用作预防或治疗精神分裂症等的药物的化合物。 由式（1x）表示的化合物：其中每个符号如说明书或式（1）所述：其中各符号如说明书所述或其盐。W1-W2（1）。
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4.发明授权公开(公告)号：US09150588B2
公开(公告)日：2015-10-06
申请号：US13816011
申请日：2011-08-09
IPC分类号： A61K31/501 , C07D403/04 , C07D498/04 , C07D401/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/14 , C07D491/048 , C07D401/14 , C07D409/04 , C07D413/14
CPC分类号： C07D498/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048
摘要： A compound having PDE inhibitory represented by formula (1), W1-W2 (1), wherein (i) W1 is and W2 is (ii) W1 is and W2 is or (iii) W1 is and W2 is or a pharmaceutically acceptable salt thereof; and a method of treating or preventing schizophrenia.
摘要翻译： 由式（1）表示的具有PDE抑制剂的化合物，W1-W2（1）其中（i）W1和W2是（ii）W1和W2是或（iii）W1和W2是或其药学上可接受的盐 的; 以及治疗或预防精神分裂症的方法。
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公开(公告)号：US20130137700A1
公开(公告)日：2013-05-30
申请号：US13814035
申请日：2011-08-03
申请人： Tomoaki Hasui , Makoto Fushimi , Hironori Kokubo , Takenori Hitaka , Shotaro Miura , Jun Kunitomo , Takahiko Taniguchi
发明人： Tomoaki Hasui , Makoto Fushimi , Hironori Kokubo , Takenori Hitaka , Shotaro Miura , Jun Kunitomo , Takahiko Taniguchi
IPC分类号： C07D403/14 , C07D471/04 , C07D401/12 , C07D487/04 , C07D401/14
CPC分类号： C07D403/14 , A61K9/2018 , A61K9/2059 , A61K31/00 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： Provided is a compound having a PDE10A inhibitory action, and useful as a medicament for the prophylaxis or treatment of mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.
摘要翻译： 提供具有PDE10A抑制作用的化合物，可用作预防或治疗精神疾病如精神分裂症等的药物等。 由式（I）表示的化合物或其盐，其中每个符号如说明书中所定义。
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公开(公告)号：US20100197651A1
公开(公告)日：2010-08-05
申请号：US12656605
申请日：2010-02-04
申请人： Takahiko Taniguchi , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
发明人： Takahiko Taniguchi , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
IPC分类号： A61K31/501 , C07D403/04 , C07D413/14 , A61K31/5377 , A61P25/18
CPC分类号： C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on.A compound of formula (I0): wherein R1 represents a substituent, R2 represents a hydrogen atom, or a substituent, R3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
摘要翻译： 本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。 式（I0）的化合物：其中R1表示取代基，R2表示氢原子或取代基，R3表示氢原子或取代基，环A表示可被取代的芳香环，环B表示 可被取代的5元杂芳环或其盐。
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7.发明授权Pyridazinone compounds as phosphodiesterase inhibitors and methods of treating disorders 有权哒嗪酮化合物作为磷酸二酯酶抑制剂和治疗疾病的方法公开(公告)号：US08916566B2
公开(公告)日：2014-12-23
申请号：US12656605
申请日：2010-02-04
IPC分类号： A61K31/501 , C07D405/04 , C07D401/14 , C07D409/14 , C07D405/14 , C07D403/14 , C07D403/04 , C07D409/04 , C07D413/04 , A61P25/18 , A61K9/20
CPC分类号： C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on.A compound of formula (I0): wherein R1 represents a substituent, R2 represents a hydrogen atom, or a substituent, R3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
摘要翻译： 本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。 式（I0）的化合物：其中R1表示取代基，R2表示氢原子或取代基，R3表示氢原子或取代基，环A表示可被取代的芳香环，环B表示 可被取代的5元杂芳环或其盐。
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公开(公告)号：US20120277204A1
公开(公告)日：2012-11-01
申请号：US13543207
申请日：2012-07-06
申请人： Takahiko TANIGUCHI , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
发明人： Takahiko TANIGUCHI , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
IPC分类号： A61K31/501 , C07D413/14 , A61K31/5377 , C07D401/14 , A61P25/18 , C07D409/04 , C07D405/14 , C07D409/14 , C07D403/14 , C07D403/04 , C07D413/04
CPC分类号： C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
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公开(公告)号：US20120028951A1
公开(公告)日：2012-02-02
申请号：US13148172
申请日：2010-02-04
申请人： Takahiko Taniguchi , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
发明人： Takahiko Taniguchi , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
IPC分类号： A61K31/501 , C07D413/14 , C07D401/14 , C07D403/14 , A61P25/18 , C07D405/04 , C07D409/04 , C07D405/14 , C07D409/14 , A61K31/5377 , C07D403/04 , C07D413/04
CPC分类号： C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
摘要翻译： 本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。 式（I0）的化合物，其中R1表示取代基; R2表示氢原子或取代基; R3表示氢原子或取代基; 环A表示可被取代的芳环，环B表示可被取代的5元杂芳环或其盐。
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公开(公告)号：US08778944B2
公开(公告)日：2014-07-15
申请号：US13543207
申请日：2012-07-06
申请人： Takahiko Taniguchi , Akira Kawada , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
发明人： Takahiko Taniguchi , Akira Kawada , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
摘要翻译： 本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。 式（I0）的化合物，其中R1表示取代基; R2表示氢原子或取代基; R3表示氢原子或取代基; 环A表示可被取代的芳环，环B表示可被取代的5元杂芳环或其盐。
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