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公开(公告)号:US20100197651A1
公开(公告)日:2010-08-05
申请号:US12656605
申请日:2010-02-04
申请人: Takahiko Taniguchi , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
发明人: Takahiko Taniguchi , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
IPC分类号: A61K31/501 , C07D403/04 , C07D413/14 , A61K31/5377 , A61P25/18
CPC分类号: C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要: The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on.A compound of formula (I0): wherein R1 represents a substituent, R2 represents a hydrogen atom, or a substituent, R3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
摘要翻译: 本发明提供具有PDE抑制作用的化合物,其可用作预防或治疗精神分裂症等的药物。 式(I0)的化合物:其中R1表示取代基,R2表示氢原子或取代基,R3表示氢原子或取代基,环A表示可被取代的芳香环,环B表示 可被取代的5元杂芳环或其盐。
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公开(公告)号:US20120277204A1
公开(公告)日:2012-11-01
申请号:US13543207
申请日:2012-07-06
申请人: Takahiko TANIGUCHI , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
发明人: Takahiko TANIGUCHI , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
IPC分类号: A61K31/501 , C07D413/14 , A61K31/5377 , C07D401/14 , A61P25/18 , C07D409/04 , C07D405/14 , C07D409/14 , C07D403/14 , C07D403/04 , C07D413/04
CPC分类号: C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要: The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
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公开(公告)号:US20120028951A1
公开(公告)日:2012-02-02
申请号:US13148172
申请日:2010-02-04
申请人: Takahiko Taniguchi , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
发明人: Takahiko Taniguchi , Akira Kawada , Mitsuyo Kondo , John F. Quinn , Jun Kunitomo , Masato Yoshikawa , Makoto Fushimi
IPC分类号: A61K31/501 , C07D413/14 , C07D401/14 , C07D403/14 , A61P25/18 , C07D405/04 , C07D409/04 , C07D405/14 , C07D409/14 , A61K31/5377 , C07D403/04 , C07D413/04
CPC分类号: C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要: The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
摘要翻译: 本发明提供具有PDE抑制作用的化合物,其可用作预防或治疗精神分裂症等的药物。 式(I0)的化合物,其中R1表示取代基; R2表示氢原子或取代基; R3表示氢原子或取代基; 环A表示可被取代的芳环,环B表示可被取代的5元杂芳环或其盐。
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公开(公告)号:US20050209447A1
公开(公告)日:2005-09-22
申请号:US10343095
申请日:2001-07-25
申请人: Takashi Ito , Yoko Tanaka , Mitsuyo Kondo
发明人: Takashi Ito , Yoko Tanaka , Mitsuyo Kondo
CPC分类号: C12P21/02
摘要: It is intended to produce a target protein in procaryotic or eucaryotic cells. A DNA encoding the full-length amino acid sequence or a part of the same of a target protein is prepared and the target protein is produced by a gene recombination technique with the use of this DNA.
摘要翻译: 用于在原核细胞或真核细胞中产生靶蛋白。 制备编码全长氨基酸序列或其一部分靶蛋白的DNA,并通过使用该DNA的基因重组技术产生靶蛋白。
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公开(公告)号:US06825165B1
公开(公告)日:2004-11-30
申请号:US09857815
申请日:2001-06-08
申请人: Takashi Ito , Mitsuyo Kondo , Yoko Tanaka , Masayuki Kobayashi , Koichi Igarashi , Reiko Sasada , Osamu Nishimura
发明人: Takashi Ito , Mitsuyo Kondo , Yoko Tanaka , Masayuki Kobayashi , Koichi Igarashi , Reiko Sasada , Osamu Nishimura
IPC分类号: C07K1400
CPC分类号: C07K14/475 , A61K38/00 , C07K14/485
摘要: The betacellulin mutein or its salt of the present invention is useful for better therapeutic drug for diabetes. Since they have intact BTC activity and reduced EGF activity, and no antigenicity-related problems.
摘要翻译: 本发明的细胞素突变蛋白或其盐可用于更好的治疗药物用于糖尿病。 因为它们具有完整的BTC活性和降低的EGF活性,并且没有抗原性相关的问题。
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