公开(公告)号：US4923857A

公开(公告)日：1990-05-08

申请号：US312061

申请日：1989-02-17

申请人： Masayoshi Murata ,  Toshiyuki Chiba ,  Akira Yamada

发明人： Masayoshi Murata ,  Toshiyuki Chiba ,  Akira Yamada

IPC分类号： C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61P31/04 ,  C07D477/14

CPC分类号： C07D477/14

摘要： The invention relates to an antimicrobial compound of the formula: ##STR1## in which R.sup.1 is carboxy or protected carboxy,R.sup.2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.3 and R.sup.4 are each hydrogen or lower alkyl, andR.sup.5 is saturated 4 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atom(s), saturated 5 or 6-membered heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s) or saturated 5 or 6-membered heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s), wherein said aliphatic heterocyclic group may be substituted by one or more suitable substituent(s) selected from a group consisting of hydroxy, protected hydroxy, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, halogen, lower alkoxy, lower alkyl, lower alkoxy(lower)alkyl, imino, protected imino, lower alkylamino, protected lower alkylamino, mono(or di)-(lower)alkylcarbamoyloxy, lower alkylidene, lower alkanimidoyl and imino-protective group, or pharmaceutically acceptable salts thereof.

公开(公告)号：US5081237A

公开(公告)日：1992-01-14

申请号：US472270

申请日：1990-01-30

申请人： Masayoshi Murata ,  Toshiyuki Chiba ,  Akira Yamada

发明人： Masayoshi Murata ,  Toshiyuki Chiba ,  Akira Yamada

IPC分类号： C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61P31/04 ,  C07D477/14

CPC分类号： C07D477/14

摘要： The invention relates to novel intermediate compounds for preparation of compounds of high antimicrobial activity, said intermediate compounds being of one of the formulas: ##STR1## wherein R.sup.1 is carboxy or protected carboxy,R.sup.2 is hydroxy(lower)alkyl or protected hyroxy(lower)alkyl,R.sup.3 and R.sup.4 are each hydrogen or lower alkyl,R.sup.5 is a saturated heterocyclic group, andR.sup.6 is aryl or lower alkoxy,or pharmaceutically acceptable salts thereof.

公开(公告)号：US5241064A

公开(公告)日：1993-08-31

申请号：US587037

申请日：1990-09-24

申请人： Masayoshi Murata ,  Toshiyuki Chiba ,  Fumiyuki Shirai ,  Kenichi Washizuka ,  Motohiro Hino

发明人： Masayoshi Murata ,  Toshiyuki Chiba ,  Fumiyuki Shirai ,  Kenichi Washizuka ,  Motohiro Hino

IPC分类号： C07B53/00 ,  C07D205/08 ,  C12P7/42 ,  C12P41/00

CPC分类号： C12R1/07 ,  C07D205/08 ,  C12P41/004 ,  C12P7/42 ,  Y02P20/55

摘要： Preparation of optically active 3-substituted azetidinones of the formula (I) ##STR1## in which R.sup.1 is a hydroxy-protective group wherein an allylic alcohol of the formula (II) ##STR2## is acylated, then subjected to asymmetric enzymatic hydrolysis yielding the R-allylic alcohol. The hydroxyl group is protected and then stereoselectively reacted with an amine which is subsequently cyclized to yield the desired 3-substituted azetidinone. Two new species of microorganisms have been isolated, Pimelobacter sp. No. 1254 and Bacillus megaterium No. 1253 which exhibit stereoselective esterase activity.

公开(公告)号：US5286721A

公开(公告)日：1994-02-15

申请号：US853746

申请日：1992-06-12

申请人： Masayoshi Murata ,  Toshiyuki Chiba ,  Hideo Tsutsumi ,  Kohji Hattori ,  Satoru Kuroda ,  Hiroaki Ohtake ,  Fumiyuki Shirai

发明人： Masayoshi Murata ,  Toshiyuki Chiba ,  Hideo Tsutsumi ,  Kohji Hattori ,  Satoru Kuroda ,  Hiroaki Ohtake ,  Fumiyuki Shirai

IPC分类号： C07D477/14 ,  C07D477/00

CPC分类号： C07D477/14

摘要： 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds of the formula: ##STR1## in which R.sup.1 is carboxy, COO.sup.-- or protected carboxy,R.sup.2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.8 is hydrogen or lower alkyl,Z is a group of the formula: ##STR2## wherein R.sup.3 is hydrogen; lower alkyl or lower alkenyl, each of which is optionally substituted by the group consisting of lower alkoxy, carbamoyl, hydroxy, halogen, mono(or di)(lower)alkylcarbamoyl, mono(or di)(lower)alkenylcarbamoyl, mono(or bis)[hydroxy(lower)alkyl]carbamoyl, optionally substituted cyclic-aminocarbonyl, acylamino, ureido, optionally substituted heterocyclic-carbonylamino, carbamoyloxy, mono(or di)(lower)alkylcarbamoyloxy, lower alkylthio, halo(lower)alkylthio, optionally substituted heterocyclicthio, optionally substituted heterocyclic group, optionally substituted aryl, and acyl;R.sup.9 is hydrogen or lower alkyl, andR.sup.10 is lower alkyl,or pharmaceutically acceptable salts thereof, which is useful as an antimicrobial agent.

摘要翻译： PCT No.PCT / JP91 / 01394 Sec。 371日期：1992年6月12日 102（e）日期1992年6月12日PCT 1991年10月14日PCT PCT。 出版物WO92 / 06978 日期：4月30日，1992.1-氮杂双环（3.2.0）庚-2-烯-2-羧酸化合物，其结构式如下：（*化学结构*）其中R 1为羧基，COO-或被保护的羧基，R 2为羟基（ 低级）烷基或被保护的羟基（低级）烷基，R 8是氢或低级烷基，Z是下列基团：（*化学结构*）其中R 3是氢; 羟基，卤素，单（或二）（低级）烷基氨基甲酰基，单（或二）（低级）烯基氨基甲酰基，单（或双（低级））链烯基氨基甲酰基， ）（羟基（低级）烷基）氨基甲酰基，任选取代的环氨基羰基，酰氨基，脲基，任选取代的杂环羰基氨基，氨基甲酰氧基，单（或二）（低级）烷基氨基甲酰氧基，低级烷硫基，卤（低级）烷硫基， ，任选取代的杂环基，任选取代的芳基和酰基; R9为氢或低级烷基，R10为低级烷基，或其药学上可接受的盐，可用作抗微生物剂。

公开(公告)号：US5102877A

公开(公告)日：1992-04-07

申请号：US508167

申请日：1990-04-12

申请人： Masayoshi Murata ,  Toshiyuki Chiba ,  Hideo Tsutsumi ,  Kohji Hattori ,  Satoru Kuroda ,  Hiroaki Ohtake ,  Fumiyuki Shirai

发明人： Masayoshi Murata ,  Toshiyuki Chiba ,  Hideo Tsutsumi ,  Kohji Hattori ,  Satoru Kuroda ,  Hiroaki Ohtake ,  Fumiyuki Shirai

IPC分类号： C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61P31/04 ,  C07D477/14 ,  C07D519/00 ,  C07F7/18

CPC分类号： C07D477/14 ,  C07F7/186 ,  Y02P20/55

摘要： 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxyic acids having antimicrobial activity have been prepared.

公开(公告)号：US5075437A

公开(公告)日：1991-12-24

申请号：US518993

申请日：1990-05-04

申请人： Takeshi Nakai ,  Fumiyuki Shirai ,  Toshiyuki Chiba ,  Hiroaki Ohtake

发明人： Takeshi Nakai ,  Fumiyuki Shirai ,  Toshiyuki Chiba ,  Hiroaki Ohtake

IPC分类号： C07D205/08 ,  C07D417/06 ,  C07F7/18

CPC分类号： C07D417/06 ,  C07D205/08 ,  C07F7/186 ,  Y02P20/55

摘要： The invention relates to the preparation of 3,4-disubstituted-2-azetidinone compounds of the formula: ##STR1## in which R.sup.1 is hydrogen or amido-protective group, R.sup.2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R.sup.3 is lower alkyl, and R.sup.4 is 1-(lower)alkyl-1-hydroxy(C.sub.2 -C.sub.6)alkyl, 1-(lower)alkyl-1-(protected hydroxy)-(C.sub.2 -C.sub.6)alkyl or 2-thioxothiazolidin-3-yl, useful as an intermediate for the production of antimicrobial agents by reacting a compound a compound of the formula: ##STR2## in which R.sup.5 is acyl, or salts thereof, with a compound of the formula:R.sup.3 --CH.sub.2 CO--R.sup.4or salts thereof, in the presence of an enolizating agent selected from the group consisting of stannous(lower)alkylsulfonate and stannous perhalo(lower)alkylsulfonate.

公开(公告)号：US4393059A

公开(公告)日：1983-07-12

申请号：US302639

申请日：1981-09-15

申请人： Takao Takaya ,  Hisashi Takasugi ,  Kiyoshi Tsuji ,  Toshiyuki Chiba

发明人： Takao Takaya ,  Hisashi Takasugi ,  Kiyoshi Tsuji ,  Toshiyuki Chiba

IPC分类号： C07D277/20 ,  C07D285/06 ,  C07D501/59 ,  C07D501/20 ,  A61K31/545

CPC分类号： C07D277/20 ,  C07D285/06 ,  C07D501/20

摘要： The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon which may be substituted with halogen, carboxy or pharmaceutically acceptable esterified carboxy,R.sup.5 is carboxy or pharmaceutically acceptable esterified carboxy,R.sup.6 is amino or protected amino andR.sup.7 is lower alkanesulfonyl or arenesulfonyl and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

摘要翻译： 本发明特别涉及下式的顺式化合物：其中R 2为氢或可被卤素，羧基或药学上可接受的酯化羧基取代的脂族烃基，R 5为羧基或药学上可接受的酯化羧基，R6为氨基或保护基 氨基和R7是低级烷基磺酰基或芳烃磺酰基及其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗感染性疾病中的用途。

公开(公告)号：US06642904B2

公开(公告)日：2003-11-04

申请号：US09984146

申请日：2001-10-29

申请人： Takao Yokoshima ,  Toshiyuki Chiba ,  Shiro Sugimura ,  Hideki Kobayashi

发明人： Takao Yokoshima ,  Toshiyuki Chiba ,  Shiro Sugimura ,  Hideki Kobayashi

IPC分类号： H01Q138

CPC分类号： H01Q9/27 ,  H01Q1/22 ,  H01Q1/362 ,  H01Q1/38 ,  H01Q1/40 ,  H01Q5/314 ,  H01Q5/357

摘要： An antenna is provided to improve the gain and to eliminate various negative effects caused by a surrounding environment in which the antenna is mounted, such as the effects caused by neighboring metal plates and the like, while providing an antenna structure to facilitate its assembly into various communication devices. The antenna emitting radio waves at a center frequency has an antenna main body and a grounding line section connected to the ground-side of the coaxial cable for supplying power to the antenna main body. The grounding line section starts from a reference point and extends in a loop so as to surround the antenna main body, and portions of the conductor line are severed so as to provide a first end terminal and a second end terminal so that the length of the conductor line from the reference point to the first end terminal corresponds to one quarter of a wavelength of the center frequency or its integral multiple.

公开(公告)号：US06597315B2

公开(公告)日：2003-07-22

申请号：US09920846

申请日：2001-08-03

申请人： Takao Yokoshima ,  Yasushige Ueoka ,  Hideki Kobayashi ,  Shiro Sugimura ,  Toshiyuki Chiba

发明人： Takao Yokoshima ,  Yasushige Ueoka ,  Hideki Kobayashi ,  Shiro Sugimura ,  Toshiyuki Chiba

IPC分类号： H01Q138

CPC分类号： H01Q1/243 ,  H01Q1/362 ,  H01Q1/38 ,  H01Q7/00 ,  H01Q21/29

摘要： A high gain antenna of a compact external dimensions enables various devices for processing radio signals to include the antenna within the internal circuitry, so that there is no need to extend the antenna and avoid a danger of breaking the antenna, and the external appearance of the device is improved. The antenna is constructed by connecting antenna elements and in series, in which each antenna element has an inductance sections and a capacitance sections connected in parallel in such a way that magnetic fields generated by the inductance sections are oriented to intersect with one another so as to increase the signal gain.

公开(公告)号：US4698337A

公开(公告)日：1987-10-06

申请号：US912212

申请日：1986-09-25

申请人： Takao Takaya ,  Hisashi Takasugi ,  Kiyoshi Tsuji ,  Toshiyuki Chiba

发明人： Takao Takaya ,  Hisashi Takasugi ,  Kiyoshi Tsuji ,  Toshiyuki Chiba

IPC分类号： C07D277/20 ,  C07D501/20 ,  C07D501/36 ,  A61K31/545

CPC分类号： C07D277/587

摘要： The invention relates to novel cephem compounds, of high antimicrobial activity, of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl substituted with 1 to 3 halogen atoms,R.sup.3 is thiadiazolylthiomethyl which may be substituted with lower alkyl, or tetrazolylthiomethyl which may be substituted with lower alkyl or lower alkenyl, andR.sup.4 is carboxy or protected carboxy, and a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及具有高抗微生物活性的新颖的头孢烯化合物，其具有下式：其中R 1为氨基或被保护的氨基，R 2为被1至3个卤素原子取代的低级烷基，R 3为可被低级烷基取代的噻二唑基硫甲基， 或可以被低级烷基或低级链烯基取代的四唑基硫甲基，R4是羧基或被保护的羧基，及其药学上可接受的盐。