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1.发明授权Phosphate derivatives, process for producing phosphate derivatives and fillers for human hard tissues containing the same 失效磷酸盐衍生物，用于生产磷酸盐衍生物的方法和用于含有它们的人类硬组织的填料
公开(公告)号：US4442239A
公开(公告)日：1984-04-10
申请号：US347429
申请日：1982-02-10
IPC分类号： C07F9/113 , A61K6/00 , A61K6/08 , A61K6/083 , C07F9/09 , C07F9/12 , C08F22/10 , C08F30/02 , C08F136/14 , A61K5/00 , C08F136/22 , C08F230/02
CPC分类号： C08F30/02 , A61K6/0088 , A61K6/083 , C07F9/091 , C07F9/12
摘要： Phosphate derivatives represented by the formula ##STR1## wherein R represents a group containing at least one reactive double bond and A represents a group which may optionally contain reactive double bonds are disclosed. The phosphate derivatives of the present invention have at least two reactive double bonds, and polymers prepared from these phosphate derivatives in the presence or absence of other polymerizable monomers are useful as fillers for human hard tissues such as bones and teeth.
摘要翻译： 公开了由式“IMAGE”表示的磷酸酯衍生物，其中R表示含有至少一个反应性双键的基团，A表示可任选地含有反应性双键的基团。 本发明的磷酸酯衍生物具有至少两个反应性双键，并且在其它可聚合单体存在或不存在下由这些磷酸酯衍生物制备的聚合物可用作人类硬组织如骨骼和牙齿的填料。
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公开(公告)号：US4404150A
公开(公告)日：1983-09-13
申请号：US231914
申请日：1981-02-05
IPC分类号： C08F30/00 , A61K6/00 , A61K6/083 , C07F9/09 , C07F9/6574 , C07F9/6578 , C08F30/02 , C09J137/00 , C07F9/15
CPC分类号： C07F9/6578 , C07F9/098 , C07F9/6574
摘要： A cyclic pyrophosphate derivative having the formula ##STR1## wherein A represents a direct bond between the two phenyl rings or a divalent moiety selected from the group consisting of lower alkylene, aryl substituted lower alkylene, cycloalkylidene, sulfonyl and oxy;R.sup.1 represents alkyl, acryloyloxy lower alkyl or methacryloyloxy lower alkyl in which the lower alkyl can be substituted with halogen; andR.sup.2 represents independently hydrogen, halogen, lower alkyl or lower alkoxy;a method of preparing the same, a dental filling material comprising the same and a method of filling dental cavities are disclosed.
摘要翻译： 具有下式的环状焦磷酸酯衍生物，其中A表示两个苯环之间的直接键或选自低级亚烷基，芳基取代的低级亚烷基，亚环烷基，磺酰基和氧基的二价基团; R1表示低级烷基可被卤素取代的烷基，丙烯酰氧基低级烷基或甲基丙烯酰氧基低级烷基; 并且R 2独立地表示氢，卤素，低级烷基或低级烷氧基; 公开了其制备方法，包含该牙科填充材料的牙科填充材料和填充牙腔的方法。
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公开(公告)号：US4397944A
公开(公告)日：1983-08-09
申请号：US221512
申请日：1980-12-30
IPC分类号： G01N33/50 , A61K8/00 , A61K8/34 , A61K8/46 , A61K8/49 , A61K8/73 , A61K8/86 , A61Q11/00 , C12Q1/04 , C12Q1/14 , G01N33/52 , C12Q1/00 , G01N31/16 , G01N33/48
CPC分类号： A61Q11/00 , A61K8/44 , A61K8/49 , A61K8/4926 , C12Q1/04 , G01N33/52 , A61K2800/45
摘要： Compositions capable of evaluating dental caries activity by making use of color reaction, which are composed of an aqueous solution containing coloring agents and water-soluble substances that are to produce an osmotic pressure higher than the physiological one on the cell membrane of cariogenic bacteria but free from any buffer action by themselves. Upon introducing dental plaque of a dental caries patient into this solution and thus measuring activity of the sordes by means of color reaction, it is possible to evaluate readily the status praesens of dental caries and its activity without any cultivation of cariogenic bacteria being required.
摘要翻译： 能够通过使用颜色反应评估龋齿活性的组合物，其由含有着色剂的水溶液和水溶性物质组成，所述水溶液产生的渗透压高于致龋细菌细胞膜上的生理学渗透压，但是游离 从任何缓冲动作本身。 将龋齿患者的牙菌斑引入该溶液中，从而通过颜色反应来测量主体的活动性，可以容易地评价龋齿状态的赞美及其活性，而不需要任何培养龋齿细菌。
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公开(公告)号：US4783491A
公开(公告)日：1988-11-08
申请号：US756974
申请日：1985-06-26
CPC分类号： A61K6/002
摘要： A dental material having X-ray contrastability which is excellent in strength, aesthetic appearance, workability, marginal blocking and the like and possesses high value in use can be provided by using a methacrylate having an aromatic hydrocarbon substituted by bromine in the molecule as polymerizable monomer and, as occasion demands, combining a filler and/or hardener suitably selected with this compound.
摘要翻译： PCT No.PCT / JP84 / 00587 Sec。 371日期：1985年6月26日第 102（e）日期1985年6月26日PCT提交1984年12月12日PCT公布。 出版物WO86 / 03404 日期：1986年6月19日。具有X射线对比性优异的牙科材料，其强度，美学外观，加工性，边缘粘连等优异，使用价值高，可以通过使用具有被 分子中的溴作为可聚合单体，并且根据需要，将由该化合物适当选择的填料和/或硬化剂组合。
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公开(公告)号：US20120135059A1
公开(公告)日：2012-05-31
申请号：US13387992
申请日：2010-07-30
CPC分类号： A61Q11/00 , A61K6/0008 , A61K6/0017 , A61K6/0067 , A61K6/0276 , A61K6/0612 , A61K8/24 , A61K8/25 , A61K33/06 , A61K33/16 , A61K33/42 , A61K2800/412 , A61K2800/88 , A61K2800/882 , A61K2300/00
摘要： Object of the present invention is to provide a preparation for oral cavity that is appropriately usable as a prophylactic agent for dental caries, a therapeutic agent for dental caries at early stage, a prophylactic and/or therapeutic agent for dentinal hypersensitivity, a preparation for the lining of a dentin cavity surface, or the like, which has a superior effect of sealing the dentinal tubules, is capable of improving the acid resistance of the teeth and re-calcifying the teeth, ensures a short-time treatment with an easy operation, and has a high safety and good aesthetic properties. The object is achieved by a preparation for oral cavity such as a prophylactic agent for dental caries and/or a therapeutic agent for dental caries at early stage, a prophylactic and/or therapeutic agent for dentinal hypersensitivity, a preparation for the lining of a dentin cavity surface, or the like, consisting of a liquid (A), in which fluoro-alumino-silicate glass microparticles are dispersed, and an aqueous inorganic phosphoric acid solution (B).
摘要翻译： 本发明的目的在于提供适合用作龋齿预防剂，早期龋齿治疗剂，牙本质超敏反应的预防和/或治疗剂的口腔用制剂， 具有优异的密封牙质小管效果的牙本质表面等的衬垫能够提高牙齿的耐酸性和再钙化，能够容易地进行短时间的处理， 并具有很高的安全性和良好的美观性。 该目的通过口腔制剂如龋齿预防剂和/或早期龋齿治疗剂，牙本质超敏反应的预防和/或治疗剂，牙本质衬里的制备来实现 空腔表面等，其中分散有氟铝硅酸盐玻璃微粒的液体（A）和无机磷酸水溶液（B）组成。
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公开(公告)号：US5306338A
公开(公告)日：1994-04-26
申请号：US970635
申请日：1992-11-03
申请人： Masayoshi Tsunekawa
发明人： Masayoshi Tsunekawa
CPC分类号： A61K6/0067 , A61K6/0091
摘要： A two-part dental restoration composition composed of a powder and a liquid which are to be combined and evenly mixed prior to usage. The powder is composed of a fluoride containing and releasing glass having an average particulate size under one micron, an aromatic sulfinic acid or its salt and a tertiary amine. The liquid is composed of water-soluble methacryloxyalkyl phosphate, dimethacrylates, diluent monomers and a photoinitiator.
摘要翻译： 由粉末和液体组成的两部分牙齿修复物组合物，其在使用前将被组合并均匀混合。 粉末由平均粒径在1微米以下的含氟化物和释放玻璃，芳香族亚磺酸或其盐和叔胺组成。 液体由水溶性甲基丙烯酰氧基烷基磷酸酯，二甲基丙烯酸酯，稀释剂单体和光引发剂组成。
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公开(公告)号：US08354117B2
公开(公告)日：2013-01-15
申请号：US13387992
申请日：2010-07-30
CPC分类号： A61Q11/00 , A61K6/0008 , A61K6/0017 , A61K6/0067 , A61K6/0276 , A61K6/0612 , A61K8/24 , A61K8/25 , A61K33/06 , A61K33/16 , A61K33/42 , A61K2800/412 , A61K2800/88 , A61K2800/882 , A61K2300/00
摘要： Object of the present invention is to provide a preparation for oral cavity that is appropriately usable as a prophylactic agent for dental caries, a therapeutic agent for dental caries at early stage, a prophylactic and/or therapeutic agent for dentinal hypersensitivity, a preparation for the lining of a dentin cavity surface, or the like, which has a superior effect of sealing the dentinal tubules, is capable of improving the acid resistance of the teeth and re-calcifying the teeth, ensures a short-time treatment with an easy operation, and has a high safety and good aesthetic properties. The object is achieved by a preparation for oral cavity such as a prophylactic agent for dental caries and/or a therapeutic agent for dental caries at early stage, a prophylactic and/or therapeutic agent for dentinal hypersensitivity, a preparation for the lining of a dentin cavity surface, or the like, consisting of a liquid (A), in which fluoro-alumino-silicate glass microparticles are dispersed, and an aqueous inorganic phosphoric acid solution (B).
摘要翻译： 本发明的目的在于提供适合用作龋齿预防剂，早期龋齿治疗剂，牙本质超敏反应的预防和/或治疗剂的口腔用制剂， 具有优异的密封牙质小管效果的牙本质表面等的衬垫能够提高牙齿的耐酸性和再钙化，能够容易地进行短时间的处理， 并具有很高的安全性和良好的美观性。 该目的通过口腔制剂如龋齿预防剂和/或早期龋齿治疗剂，牙本质超敏反应的预防和/或治疗剂，牙本质衬里的制备来实现 空腔表面等，其中分散有氟铝硅酸盐玻璃微粒的液体（A）和无机磷酸水溶液（B）组成。
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公开(公告)号：US20050207978A1
公开(公告)日：2005-09-22
申请号：US11080877
申请日：2005-03-14
CPC分类号： A61K49/006
摘要： Disclosed is a dental-caries detecting solution prepared by dissolving a dye capable of staining a carious region of a tooth to provide enhanced visibility of the carious region, in a water-miscible organic solvent, which is capable of distinctively staining only a first decalcified layer, or an outer layer of a softened dentine, to be removed, absolutely without staining a second layer, or an inner layer of the softened dentine, which should not be removed. In the dental-caries detecting solution, the water-miscible organic solvent contains a compound having a carbon number of 11 or more and including one or more hydroxyl groups. The water-miscible organic solvent is adjusted such that the dental-caries detecting solution has a viscosity of 300 to 1500 Cp.
摘要翻译： 公开了一种龋齿检测溶液，其通过将能够染色牙齿的龋齿的染料溶解在水混溶性有机溶剂中，以提高龋齿的可见度，所述龋齿检测溶液能够仅区别地染色第一脱钙层 ，或软化牙本质的外层，绝对不会污染第二层，或软骨化牙质的内层，不应被去除。 在牙科检测溶液中，水混溶性有机溶剂含有碳数为11以上并且包含一个或多个羟基的化合物。 调节水混溶性有机溶剂，使得龋齿检测溶液的粘度为300〜1500cp。
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公开(公告)号：US5112880A
公开(公告)日：1992-05-12
申请号：US491002
申请日：1990-03-09
CPC分类号： A61K6/0029 , A61K6/0067 , A61K6/0082 , A61K6/0088 , A61K6/0091
摘要： A light-curable orthodontic bracket adhesive composition is provided for bonding an orthodontic bracket to the surface of a human tooth. The composition contains a particulate filler material, an acrylate-based resin, and a photoinitiator composition effective to catalyze polymerization upon irradiation. A method of using the composition is also provided.
摘要翻译： 提供了一种用于将正牙托架粘合到人牙齿表面的可光固化的正牙支架粘合剂组合物。 该组合物含有颗粒状填充材料，丙烯酸酯类树脂和在照射时有效催化聚合的光引发剂组合物。 还提供了使用该组合物的方法。
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