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公开(公告)号：US11975069B2
公开(公告)日：2024-05-07
申请号：US17143871
申请日：2021-01-07
发明人： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood, Jr. , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
CPC分类号： A61K39/39 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2770/32634 , Y02A50/30
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
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公开(公告)号：US11541017B2
公开(公告)日：2023-01-03
申请号：US15484892
申请日：2017-04-11
发明人： Ana Jaklenec , Xian Xu , Lowell L. Wood, Jr. , Philip A. Welkhoff , William Gates , Boris Nikolic , Robert S. Langer
IPC分类号： A61K9/50 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A61K31/375 , A61K31/593 , A61K31/714 , A61K31/18 , A61K31/26 , A61K31/30 , A61K31/519 , A61K47/26 , A61K47/36 , A61K31/295 , A61K33/30 , A61K31/07 , A61K33/18 , A23L27/00 , A23L33/10 , A61K9/48 , A61K31/23 , A61K33/26 , A61K45/06
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
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公开(公告)号：US20190076631A1
公开(公告)日：2019-03-14
申请号：US16130368
申请日：2018-09-13
发明人： Kevin McHugh , Ana Jaklenec , Robert S. Langer
摘要： Microdevices with complex three-dimensional (3D) internal and external structures are described. The microdevices are made by a method combining micromolding and soft lithography with an aligned sintering process. The microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), generates microdevices with complex geometries and with fully-enclosed internal cavities containing a solid or liquid. The microdevices are useful for biomedical, electromechanical, energy and environmental applications.
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公开(公告)号：US10300136B2
公开(公告)日：2019-05-28
申请号：US14572631
申请日：2014-12-16
发明人： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
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公开(公告)号：US20150164816A1
公开(公告)日：2015-06-18
申请号：US14572346
申请日：2014-12-16
发明人： Ana Jaklenec , Xian Xu , Lowell L. Wood, JR. , Philip A. Eckhoff , William Gates , Boris Nikolic , Robert S. Langer
IPC分类号： A61K9/50 , A61K47/26 , A61K47/36 , A61K31/295 , A61K33/30 , A61K31/07 , A61K31/714 , A61K31/375 , A61K31/593 , A61K33/18 , A23L1/304 , A23L1/303 , A23L1/302 , A23L1/30 , A23L1/00 , A61K31/519
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
摘要翻译： 本文描述了耐湿度和烹饪条件的盐制剂。 该制剂提供包封在耐热pH值敏感的水不溶性聚合物中的微量营养素和维生素颗粒，其被包装在盐壳内。 pH敏感的水不溶性的热稳定材料稳定微量营养素，特别是在高温下，例如在食物制备和烹饪期间，并且在所需位置例如胃，小肠等释放微量营养素。优选的pH- 敏感的聚合物在低pH下释放，小于胃中存在的pH。 颗粒可用于与盐同时递送每日推荐剂量的微量营养素，从而消除维生素丸的需要。 这在遭受严重营养不良的人群中特别重要。
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公开(公告)号：US20230372254A1
公开(公告)日：2023-11-23
申请号：US18067541
申请日：2022-12-16
发明人： Ana Jaklenec , Xian Xu , Lowell L. Wood, Jr. , Philip A. Welkhoff , William Gates , Boris Nikolic , Robert S. Langer
IPC分类号： A61K9/50 , A23L27/00 , A61K31/07 , A61K47/26 , A61K31/295 , A61K33/30 , A61K31/714 , A23P10/30 , A23L33/16 , A23L33/15 , A23L33/155 , A61K9/48 , A61K31/519 , A23L33/10 , A61K31/593 , A61K31/23 , A61K31/375 , A61K33/18 , A61K33/26 , A61K45/06 , A61K47/36
CPC分类号： A61K9/5026 , A23L27/72 , A61K31/07 , A61K47/26 , A61K31/295 , A61K33/30 , A61K31/714 , A23P10/30 , A23L33/16 , A23L33/15 , A23L33/155 , A61K9/4866 , A61K9/5073 , A61K31/519 , A61K9/501 , A23L27/74 , A23L33/10 , A61K31/593 , A61K31/23 , A61K31/375 , A61K33/18 , A61K33/26 , A61K45/06 , A61K47/36 , A23V2002/00
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
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公开(公告)号：US20230072606A1
公开(公告)日：2023-03-09
申请号：US17903586
申请日：2022-09-06
发明人： Robert S. Langer , Ana Jaklenec , Joseph Collins , Morteza Sarmadi , Aurelien vander Straeten , Maria Kanelli , John Daristotle
摘要： Disclosed are compositions that stabilize (e.g., thermo-stabilize) biological agents, such as mRNA. Also disclosed are methods of administering and using said compositions.
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公开(公告)号：US10548844B2
公开(公告)日：2020-02-04
申请号：US15372703
申请日：2016-12-08
发明人： Aaron C. Anselmo , Robert S. Langer , Ana Jaklenec
IPC分类号： A61K9/16 , A61K35/741 , A61K35/742 , A61K35/745 , A61K35/747
摘要： Methods of encapsulating microorganisms, or components thereof, for targeted enteric delivery to an animal host have been developed. In particular, the encapsulation provides a prolonged survival, extended retention and a pH-sensitive release of the encapsulated microorganisms or antigenic components thereof at targeted sites within the gastrointestinal tract. The formulations are useful for diagnostic, therapeutic and prophylactic purposes and can alter a host's microbial composition associated with a condition or a disease state.
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公开(公告)号：US20170165201A1
公开(公告)日：2017-06-15
申请号：US15372703
申请日：2016-12-08
发明人： Aaron C. Anselmo , Robert S. Langer , Ana Jaklenec
IPC分类号： A61K9/16 , A61K35/741 , A61K35/742 , A61K35/747 , A61K35/745
CPC分类号： A61K9/1652 , A23L33/135 , A61K9/1641 , A61K9/5026 , A61K9/5036 , A61K9/5073 , A61K9/5089 , A61K35/741 , A61K35/742 , A61K35/745 , A61K35/747 , A61K35/76 , A61K36/064 , A61K39/07 , A61K39/12 , A61K2039/52 , A61K2039/525 , A61K2039/542
摘要： Methods of encapsulating microorganisms, or components thereof, for targeted enteric delivery to an animal host have been developed. In particular, the encapsulation provides a prolonged survival, extended retention and a pH-sensitive release of the encapsulated microorganisms or antigenic components thereof at targeted sites within the gastrointestinal tract. The formulations are useful for diagnostic, therapeutic and prophylactic purposes and can alter a host's microbial composition associated with a condition or a disease state.
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公开(公告)号：US20210290921A1
公开(公告)日：2021-09-23
申请号：US17342978
申请日：2021-06-09
发明人： Kevin McHugh , Ana Jaklenec , Robert S. Langer
IPC分类号： A61M31/00 , A61K9/16 , A61B5/145 , A61K39/00 , A61K9/127 , A61M5/142 , A61K47/34 , A61K39/12 , A61K9/00
摘要： Microdevices with complex three-dimensional (3D) internal and external structures are described. The microdevices are made by a method combining micromolding and soft lithography with an aligned sintering process. The microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), generates microdevices with complex geometries and with fully-enclosed internal cavities containing a solid or liquid. The microdevices are useful for biomedical, electromechanical, energy and environmental applications.
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