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公开(公告)号：US10300136B2
公开(公告)日：2019-05-28
申请号：US14572631
申请日：2014-12-16
Applicant: Massachusetts Institute of Technology , Tokitae LLC
Inventor： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
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公开(公告)号：US11975069B2
公开(公告)日：2024-05-07
申请号：US17143871
申请日：2021-01-07
Applicant: Massachusetts Institute of Technology , Tokitae LLC
Inventor： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood, Jr. , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
CPC classification number: A61K39/39 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2770/32634 , Y02A50/30
Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
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Patent Agency Ranking
公开(公告)号：US20190076631A1
公开(公告)日：2019-03-14
申请号：US16130368
申请日：2018-09-13
Applicant: Massachusetts Institute of Technology
Inventor： Kevin McHugh , Ana Jaklenec , Robert S. Langer
Abstract: Microdevices with complex three-dimensional (3D) internal and external structures are described. The microdevices are made by a method combining micromolding and soft lithography with an aligned sintering process. The microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), generates microdevices with complex geometries and with fully-enclosed internal cavities containing a solid or liquid. The microdevices are useful for biomedical, electromechanical, energy and environmental applications.
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公开(公告)号：US20210290921A1
公开(公告)日：2021-09-23
申请号：US17342978
申请日：2021-06-09
Applicant: Massachusetts Institute of Technology
Inventor： Kevin McHugh , Ana Jaklenec , Robert S. Langer
IPC: A61M31/00 , A61K9/16 , A61B5/145 , A61K39/00 , A61K9/127 , A61M5/142 , A61K47/34 , A61K39/12 , A61K9/00
Abstract: Microdevices with complex three-dimensional (3D) internal and external structures are described. The microdevices are made by a method combining micromolding and soft lithography with an aligned sintering process. The microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), generates microdevices with complex geometries and with fully-enclosed internal cavities containing a solid or liquid. The microdevices are useful for biomedical, electromechanical, energy and environmental applications.
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公开(公告)号：US20210205444A1
公开(公告)日：2021-07-08
申请号：US17143871
申请日：2021-01-07
Applicant: Massachusetts Institute of Technology , Tokitae LLC
Inventor： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood, JR. , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
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公开(公告)号：US10960073B2
公开(公告)日：2021-03-30
申请号：US16401476
申请日：2019-05-02
Applicant: Massachusetts Institute of Technology , Tokitae LLC
Inventor： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood, Jr. , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
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公开(公告)号：US20190328871A1
公开(公告)日：2019-10-31
申请号：US16401476
申请日：2019-05-02
Applicant: Massachusetts Institute of Technology , Tokitae LLC
Inventor： Ana Jaklenec , William Gates , Philip A. Welkhoff , Boris Nikolic , Lowell L. Wood, JR. , Robert S. Langer , Thanh Duc Nguyen , Stephany Yi Tzeng , James J. Norman , Kevin McHugh
Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
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