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Patent Agency Ranking
公开(公告)号：US20220142566A1
公开(公告)日：2022-05-12
申请号：US17470942
申请日：2021-09-09
Applicant: Massachusetts Institute of Technology
Inventor： Hen-Wei Huang , James Byrne , Carlo Giovanni Traverso
IPC: A61B5/00 , A61B6/00 , A61B5/1473 , A61K31/4748 , A61M31/00 , A61M5/158
Abstract: Articles, systems, and methods for rapid administration and active pharmaceutical compositions to subjects exposed to radiation and/or toxins are provided by this disclosure. There are currently few interventional technologies to protect against long-term morbidity and mortality from exposure to radiation and chemical warfare. Furthermore, as commercially available technologies such as additive manufacturing and small-scale chemical reactors have become more prevalent, the risk of misuse of such technologies by terrorists and rogue nation states to manufacture nuclear, radiologic, and chemical weapons continues to increase. Articles, systems, and methods described herein combine sensing technologies with drug release components, in order to provide an approach for rapid diagnosis of and response to exposure to radiation and toxic agents.
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公开(公告)号：US12138034B2
公开(公告)日：2024-11-12
申请号：US18541818
申请日：2023-12-15
Applicant: Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
Inventor： Robert S. Langer , Carlo Giovanni Traverso , Malvika Verma , Feyisope Eweje , Christoph Winfried Johannes Steiger , Junwei Li , Nhi Phan , Hen-Wei Huang , Jacqueline Chu , John Ashraf Fou Salama
Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
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公开(公告)号：US11850034B2
公开(公告)日：2023-12-26
申请号：US17318040
申请日：2021-05-12
Applicant: Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
Inventor： Robert S. Langer , Carlo Giovanni Traverso , Malvika Verma , Feyisope Eweje , Christoph Winfried Johannes Steiger , Junwei Li , Nhi Phan , Hen-Wei Huang , Jacqueline Chu , John Ashraf Fou Salama
CPC classification number: A61B5/073 , A61B5/4845 , A61B2562/02 , A61B2562/162 , A61B2562/164
Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
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公开(公告)号：US20240108241A1
公开(公告)日：2024-04-04
申请号：US18541818
申请日：2023-12-15
Applicant: Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
Inventor： Robert S. Langer , Carlo Giovanni Traverso , Malvika Verma , Feyisope Eweje , Christoph Winfried Johannes Steiger , Junwei Li , Nhi Phan , Hen-Wei Huang , Jacqueline Chu , John Ashraf Fou Salama
CPC classification number: A61B5/073 , A61B5/4845 , A61B2562/02 , A61B2562/162 , A61B2562/164
Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
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公开(公告)号：US20210353174A1
公开(公告)日：2021-11-18
申请号：US17318040
申请日：2021-05-12
Applicant: Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
Inventor： Robert S. Langer , Carlo Giovanni Traverso , Malvika Verma , Feyisope Eweje , Christoph Winfried Johannes Steiger , Junwei Li , Nhi Phan , Hen-Wei Huang , Jacqueline Chu , John Ashraf Fou Salama
Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
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