公开(公告)号：US20240216469A1

公开(公告)日：2024-07-04

申请号：US18596376

申请日：2024-03-05

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Carlo Giovanni Traverso ,  Ameya R. Kirtane ,  Junwei Li ,  Thomas Wang ,  James Byrne ,  Alexis Jones

IPC: A61K38/17 ,  A61K31/495 ,  A61K45/06 ,  A61L24/04 ,  A61L24/06 ,  A61L24/08 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  C12N9/08

CPC classification number: A61K38/1787 ,  A61K31/495 ,  A61K45/06 ,  A61L24/046 ,  A61L24/06 ,  A61L24/08 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  C12N9/0065 ,  A61L2300/254 ,  A61L2300/256 ,  A61L2300/438 ,  A61L2400/04 ,  A61L2430/06 ,  A61L2430/16 ,  C12Y111/01006

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide a broad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

公开(公告)号：US20230101687A1

公开(公告)日：2023-03-30

申请号：US17784598

申请日：2020-12-10

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Carlo Giovanni Traverso ,  Ameya R. Kirtane ,  Junwei Li ,  Thomas Wang ,  James Byrne ,  Alexis Jones

IPC: A61L24/04 ,  A61L27/18 ,  A61L24/08 ,  A61L24/06 ,  A61L27/16 ,  A61L27/20

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide abroad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

公开(公告)号：US20220287983A1

公开(公告)日：2022-09-15

申请号：US17689314

申请日：2022-03-08

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Carlo Giovanni Traverso ,  Ameya R. Kirtane ,  Robert S. Langer ,  Hyunjoon KIM ,  Gary W. Liu ,  James Byrne ,  Daniel Reker ,  Yunhua Shi ,  Grace Junyue Zhong ,  Netra Rajesh

IPC: A61K9/51 ,  C08G63/685 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00

Abstract: The present disclosure provides branched poly(β-amino esters) (PBAEs) of Formula (I) made by reacting primary amines with diacrylates. Further provided herein are compositions comprising the polymers of Formula (I), and methods of using the compositions and polymers as described herein for the treatment of disease. L-(R)n   (I)

公开(公告)号：US20220142566A1

公开(公告)日：2022-05-12

申请号：US17470942

申请日：2021-09-09

Applicant: Massachusetts Institute of Technology

Inventor： Hen-Wei Huang ,  James Byrne ,  Carlo Giovanni Traverso

IPC: A61B5/00 ,  A61B6/00 ,  A61B5/1473 ,  A61K31/4748 ,  A61M31/00 ,  A61M5/158

Abstract: Articles, systems, and methods for rapid administration and active pharmaceutical compositions to subjects exposed to radiation and/or toxins are provided by this disclosure. There are currently few interventional technologies to protect against long-term morbidity and mortality from exposure to radiation and chemical warfare. Furthermore, as commercially available technologies such as additive manufacturing and small-scale chemical reactors have become more prevalent, the risk of misuse of such technologies by terrorists and rogue nation states to manufacture nuclear, radiologic, and chemical weapons continues to increase. Articles, systems, and methods described herein combine sensing technologies with drug release components, in order to provide an approach for rapid diagnosis of and response to exposure to radiation and toxic agents.