公开(公告)号：US09494579B2

公开(公告)日：2016-11-15

申请号：US14481044

申请日：2014-09-09

Applicant: Massachusetts Institute of Technology

Inventor： Eric D. Schwoebel ,  James D. Harper ,  Martha S. Petrovick ,  Frances E. Nargi ,  Todd H. Rider ,  Kristine E. Hogan ,  Richard H. Mathews ,  Joseph Lacirignola ,  Mark Hennessy ,  Trina R. Vian ,  Rose M. Joseph ,  Raymond S. Uttaro ,  Shaun Berry ,  Bernadette Johnson ,  Mark A. Hollis

IPC: C12M1/34 ,  C12M3/00 ,  G01N33/53 ,  C12Q1/68 ,  G01N21/64 ,  G01N33/58

CPC classification number: G01N33/5304 ,  C12M1/3461 ,  C12M1/3476 ,  C12Q1/6825 ,  G01N21/6428 ,  G01N21/6454 ,  G01N33/582 ,  C12Q2565/619 ,  C12Q2563/131

Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.

Abstract translation: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地，该方法提供了可溶性蛋白质和化学物质的检测。 此外，本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的靶颗粒，其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。

公开(公告)号：US20150050723A1

公开(公告)日：2015-02-19

申请号：US14481044

申请日：2014-09-09

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Eric D. Schwoebel ,  James D. Harper ,  Martha S. Petrovick ,  Frances E. Nargi ,  Todd H. Rider ,  Kristine E. Hogan ,  Richard H. Mathews ,  Joseph Lacirignola ,  Mark Hennessy ,  Trina R. Vian ,  Rose M. Joseph ,  Raymond S. Uttaro ,  Shaun Berry ,  Bernadette Johnson ,  Mark A. Hollis

IPC: G01N33/53

CPC classification number: G01N33/5304 ,  C12M1/3461 ,  C12M1/3476 ,  C12Q1/6825 ,  G01N21/6428 ,  G01N21/6454 ,  G01N33/582 ,  C12Q2565/619 ,  C12Q2563/131

Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.

Abstract translation: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地，该方法提供了可溶性蛋白质和化学物质的检测。 此外，本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的靶颗粒，其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。