专利检索 ap:("Massachusetts Institute of Technology" OR "Imperial College Innovations Limited") AND inv:"Jason Y. H. Chang" 第 1 页

1.

发明授权
Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids 有权

公开(公告)号：US12018315B2

公开(公告)日：2024-06-25

申请号：US16887649

申请日：2020-05-29

申请人： Massachusetts Institute of Technology , Imperial College Innovations Limited

发明人： Darrell J. Irvine , Jason Y. H. Chang , Sylvain Ladame , Dana Al Sulaiman

IPC分类号： C12Q1/6806 , C12M1/34 , C12Q1/6823 , G01N21/64

CPC分类号： C12Q1/6806 , C12M41/36 , C12Q1/6823 , G01N21/6428 , C12Q2565/1025 , C12Q2565/629

摘要： The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin.