公开(公告)号：US09724447B2

公开(公告)日：2017-08-08

申请号：US14286743

申请日：2014-05-23

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  The Children's Medical Center Corporation

发明人： Jeffrey M. Karp ,  Pedro del Nido ,  Nora Lang ,  Robert S. Langer ,  Maria Jose M. N. Pereira ,  Yuhan Lee

IPC分类号： A61L24/00 ,  A61L24/04 ,  C08G63/91 ,  A61L15/58 ,  C08G63/47 ,  A61L15/26 ,  A61L15/42 ,  C08F222/10

CPC分类号： A61L24/046 ,  A61L15/26 ,  A61L15/42 ,  A61L15/58 ,  A61L24/001 ,  A61L2400/18 ,  C08F2222/1073 ,  C08G63/47 ,  C08G63/914 ,  C08L67/04

摘要： Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a syringe or catheter but are sufficiently viscous to remain in place at the site of application and not run off the tissue. The pre-polymers are also sufficiently hydrophobic to resist washout by bodily fluids. The pre-polymers are stable in bodily fluids; that is the pre-polymer does not spontaneously crosslink in bodily fluids absent the presence of an intentionally applied stimulus to initiate crosslinking. Upon crosslinking, the adhesive exhibits significant adhesive strength in the presence of blood and other bodily fluids. The adhesive is sufficiently elastic that it is able to resist movement of the underlying tissue. The adhesive can provide a hemostatic seal. The adhesive is biodegradable and biocompatible, causing minimal inflammatory response.

公开(公告)号：US20140348896A1

公开(公告)日：2014-11-27

申请号：US14286743

申请日：2014-05-23

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  The Children's Medical Center Corporation

发明人： Jeffrey M. Karp ,  Pedro del Nido ,  Nora Lang ,  Robert S. Langer ,  Maria Jose M.N. Pereira ,  Yuhan Lee

IPC分类号： A61L24/04 ,  C08G63/91 ,  A61L24/00

CPC分类号： A61L24/046 ,  A61L15/26 ,  A61L15/42 ,  A61L15/58 ,  A61L24/001 ,  A61L2400/18 ,  C08F2222/1073 ,  C08G63/47 ,  C08G63/914 ,  C08L67/04

摘要： Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a syringe or catheter but are sufficiently viscous to remain in place at the site of application and not run off the tissue. The pre-polymers are also sufficiently hydrophobic to resist washout by bodily fluids. The pre-polymers are stable in bodily fluids; that is the pre-polymer does not spontaneously crosslink in bodily fluids absent the presence of an intentionally applied stimulus to initiate crosslinking. Upon crosslinking, the adhesive exhibits significant adhesive strength in the presence of blood and other bodily fluids. The adhesive is sufficiently elastic that it is able to resist movement of the underlying tissue. The adhesive can provide a hemostatic seal. The adhesive is biodegradable and biocompatible, causing minimal inflammatory response.

摘要翻译： 提供用作组织密封剂和粘合剂的预聚物，以及其制备和使用方法。 预聚物具有流动特性，使得它们可以通过注射器或导管施用，但足够粘稠以在施用部位保持就位，而不会从组织中流出。 预聚物也足够疏水以抵抗体液冲洗。 预聚物在体液中稳定; 也就是预聚物在体液中不会自发交联，而不存在有意施加的刺激以引发交联。 交联时，粘合剂在血液和其他体液存在下显示出显着的粘合强度。 粘合剂具有足够的弹性，使得其能够抵抗下面的组织的运动。 粘合剂可以提供止血密封。 粘合剂是可生物降解和生物相容的，导致最小的炎症反应。