公开(公告)号：US4063025A

公开(公告)日：1977-12-13

申请号：US651738

申请日：1976-01-23

申请人： Masuo Murakami ,  Kozo Takahashi ,  Kiyoshi Murase ,  Toshiyasu Mase ,  Hisashi Ida ,  Toichi Takenaka

发明人： Masuo Murakami ,  Kozo Takahashi ,  Kiyoshi Murase ,  Toshiyasu Mase ,  Hisashi Ida ,  Toichi Takenaka

IPC分类号： C07C275/40 ,  C07C125/06

CPC分类号： C07C275/40 ,  Y10S514/826

摘要： There are disclosed novel 4-substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives represented by the formula: ##STR1## wherein X represents a halogen atom; Y represents a hydrogen atom or a halogen atom; R.sub.1 represents a lower alkyl group, a carbamoyl group, a mono- or di-lower alkyl-substituted carbamoyl group, a phenyl-substituted carbamoyl group, a lower alkoxycarbonyl group, a lower alkoxy-substituted lower alkoxycarbonyl group, a phenyl-substituted lower alkoxycarbonyl group, or a cycloalkyloxycarbonyl group; and R.sub.2 represents a lower alkyl group, a cycloalkyl group, or the group shown by the formula ##STR2## wherein R.sub.3 represents a hydrogen atom or a lower alkyl group and R.sub.4 represents a hydrogen atom, a hydroxy group, or a lower alkoxy group and the pharmaceutically acceptable nontoxic salts thereof.These compounds are antiasthmatic agents useful for the prophylaxis and treatment of asthma.

摘要翻译： 公开了由下式表示的新型4-取代氨基-α-氨基甲基苄醇衍生物：其中X表示卤素原子; Y表示氢原子或卤素原子; R 1表示低级烷基，氨基甲酰基，一或二低级烷基取代的氨基甲酰基，苯基取代的氨基甲酰基，低级烷氧基羰基，低级烷氧基取代的低级烷氧基羰基，苯基取代的低级 烷氧基羰基或环烷氧基羰基; 和R 2表示低级烷基，环烷基或下式所示的基团，其中R 3表示氢原子或低级烷基，R 4表示氢原子，羟基或低级烷氧基， 其药学上可接受的无毒盐。

公开(公告)号：US4145363A

公开(公告)日：1979-03-20

申请号：US809998

申请日：1977-06-27

申请人： Masuo Murakami ,  Kozo Takahashi ,  Kiyoshi Murase ,  Toshiyasu Mase ,  Hisashi Ida ,  Toichi Takenaka

发明人： Masuo Murakami ,  Kozo Takahashi ,  Kiyoshi Murase ,  Toshiyasu Mase ,  Hisashi Ida ,  Toichi Takenaka

IPC分类号： C07C275/40 ,  C07C127/17 ,  A61K31/17

CPC分类号： C07C275/40 ,  Y10S514/826

摘要： There are disclosed novel 4-substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives represented by the formula: ##STR1## wherein X represents a halogen atom; Y represents a hydrogen atom or a halogen atom; R.sub.1 represents a lower alkyl group, a carbamoyl group, a mono- or di-lower alkyl-substituted carbamoyl group, a phenyl-substituted carbamoyl group, a lower alkoxycarbonyl group, a lower alkoxy-substituted lower alkoxycarbonyl group, a phenyl-substituted lower alkoxycarbonyl group, or a cycloalkyloxycarbonyl group; and R.sub.2 represents a lower alkyl group, a cycloalkyl group, or the group shown by the ##STR2## wherein R.sub.3 represents a hydrogen atom or a lower alkyl group and R.sub.4 represents a hydrogen atom, a hydroxy group, or a lower alkoxy group and the pharmaceutically acceptable nontoxic salts thereof. These compounds are antiasthmatic agents useful for the prophylaxis and treatment of asthma.

公开(公告)号：US3994974A

公开(公告)日：1976-11-30

申请号：US468009

申请日：1974-05-07

申请人： Masuo Murakami ,  Kozo Takahashi ,  Toshiyasu Mase ,  Kiyoshi Murase ,  Hisashi Ida

发明人： Masuo Murakami ,  Kozo Takahashi ,  Toshiyasu Mase ,  Kiyoshi Murase ,  Hisashi Ida

IPC分类号： A61K31/135 ,  A61K31/165 ,  A61K31/205 ,  C07C215/76 ,  C07C233/00 ,  C07C233/16 ,  C07C237/00 ,  C07C103/38

CPC分类号： A61K31/165 ,  A61K31/135 ,  A61K31/205 ,  C07C215/76 ,  C07C233/00 ,  C07C233/16 ,  C07C237/00

摘要： Novel .alpha.-aminomethylbenzyl alcohol derivatives, particularly .alpha.-aminoethyl-3-substituted amino-4-hydroxybenzyl alcohol derivatives. The compounds of this invention are useful as bronchodilating agents.

摘要翻译： 新的α-氨基甲基苄醇衍生物，特别是α-氨基乙基-3-取代的氨基-4-羟基苄醇衍生物。 本发明的化合物可用作支气管扩张剂。