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    4-Substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives
    2.
    发明授权
    4-Substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives 失效
    4-取代的氨基 - {6-氨基甲基苄醇衍生物

    公开(公告)号：US4063025A

    公开(公告)日：1977-12-13

    申请号：US651738

    申请日：1976-01-23

    申请人： Masuo Murakami ,  Kozo Takahashi ,  Kiyoshi Murase ,  Toshiyasu Mase ,  Hisashi Ida ,  Toichi Takenaka

    发明人： Masuo Murakami ,  Kozo Takahashi ,  Kiyoshi Murase ,  Toshiyasu Mase ,  Hisashi Ida ,  Toichi Takenaka

    IPC分类号： C07C275/40 ,  C07C125/06

    CPC分类号： C07C275/40 ,  Y10S514/826

    摘要： There are disclosed novel 4-substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives represented by the formula: ##STR1## wherein X represents a halogen atom; Y represents a hydrogen atom or a halogen atom; R.sub.1 represents a lower alkyl group, a carbamoyl group, a mono- or di-lower alkyl-substituted carbamoyl group, a phenyl-substituted carbamoyl group, a lower alkoxycarbonyl group, a lower alkoxy-substituted lower alkoxycarbonyl group, a phenyl-substituted lower alkoxycarbonyl group, or a cycloalkyloxycarbonyl group; and R.sub.2 represents a lower alkyl group, a cycloalkyl group, or the group shown by the formula ##STR2## wherein R.sub.3 represents a hydrogen atom or a lower alkyl group and R.sub.4 represents a hydrogen atom, a hydroxy group, or a lower alkoxy group and the pharmaceutically acceptable nontoxic salts thereof.These compounds are antiasthmatic agents useful for the prophylaxis and treatment of asthma.

    摘要翻译： 公开了由下式表示的新型4-取代氨基-α-氨基甲基苄醇衍生物：其中X表示卤素原子; Y表示氢原子或卤素原子; R 1表示低级烷基，氨基甲酰基，一或二低级烷基取代的氨基甲酰基，苯基取代的氨基甲酰基，低级烷氧基羰基，低级烷氧基取代的低级烷氧基羰基，苯基取代的低级 烷氧基羰基或环烷氧基羰基; 和R 2表示低级烷基，环烷基或下式所示的基团，其中R 3表示氢原子或低级烷基，R 4表示氢原子，羟基或低级烷氧基， 其药学上可接受的无毒盐。