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    Pyrazine derivatives
    1.
    发明授权
    Pyrazine derivatives 失效
    吡嗪衍生物

    公开(公告)号：US4041032A

    公开(公告)日：1977-08-09

    申请号：US534636

    申请日：1974-12-19

    申请人： Masuo Murakami ,  Kozo Takahashi ,  Yasuhumi Hirata ,  Mutsuo Takashima ,  Masaaki Takeda ,  Hiroyoshi Ino ,  Sumio Iwanami

    发明人： Masuo Murakami ,  Kozo Takahashi ,  Yasuhumi Hirata ,  Mutsuo Takashima ,  Masaaki Takeda ,  Hiroyoshi Ino ,  Sumio Iwanami

    IPC分类号： C07D241/24 ,  C07D241/28

    CPC分类号： C07D241/24 ,  Y10S514/872

    摘要： Pyrazine derivatives by the formula ##STR1## are disclosed. In the above formula, R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkoxy group, a phenyl lower alkoxy group, a phenoxy group, a mercapto group, a lower alkylthio group, a phenyl lower alkylthio group, a phenylthio group, an amino group, a substituted amino group, a lower alkyl group, a carbamoyl group or a sulfamoyl group; R.sup.3 represents a lower alkoxy group; R.sup.4, R.sup.5, and R.sup.6, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl lower alkyl group, or a phenyl group; and A represents a lower alkylene group; said R.sup.4 and A, said R.sup.5 and A, said R.sup.4 and R.sup.5, or said R.sup.5 and R.sup.6 may form a 5-membered or 6-membered nitrogen-containing heterocyclic ring which may further contain a hetero-atom together with nitrogen atom, and the pharmacologically acceptable non-toxic salts thereof. The compounds of this invention have a strong and selective antiematic activity and an effect of stimulating the gastric motility.

    摘要翻译： 披露了通过式“IMAGE”的吡嗪衍生物。 在上式中，R 1和R 2可以相同或不同，表示氢原子，卤素原子，羟基，低级烷氧基，苯基低级烷氧基，苯氧基，巯基， 低级烷硫基，苯基低级烷硫基，苯硫基，氨基，取代氨基，低级烷基，氨基甲酰基或氨磺酰基; R3表示低级烷氧基; R 4，R 5和R 6可以相同或不同，分别表示氢原子，低级烷基，环烷基，苯基低级烷基或苯基。 A表示低级亚烷基; 所述R4和A表示R5和A表示R4和R5，或所述R5和R6可以形成还可以与氮原子一起含有杂原子的5元或6元含氮杂环，并且 其药理学上可接受的无毒盐。 本发明的化合物具有强的选择性的抗活性和刺激胃动力的作用。

    Benzamide derivatives
    4.
    发明授权
    Benzamide derivatives 失效
    苯甲酰胺衍生物

    公开(公告)号：US4210660A

    公开(公告)日：1980-07-01

    申请号：US971504

    申请日：1978-12-20

    申请人： Mutsuo Takashima ,  Sumio Iwanami ,  Shinji Usuda

    发明人： Mutsuo Takashima ,  Sumio Iwanami ,  Shinji Usuda

    IPC分类号： C07D207/14 ,  C07D207/22 ,  A61K31/40

    CPC分类号： C07D207/22 ,  C07D207/14

    摘要： Benzamide derivatives represented by the formula ##STR1## wherein X represents a lower alkoxy group; Y represents a mono- or di-lower alkylamino group; Z represents a halogen atom; R.sub.1 represents a lower alkyl group; and R.sub.2 represents a hydrogen atom or a halogen atom,and their pharmacologically acceptable nontoxic salts, which are strong central nervous system depressants, in particular strong antipsychotics.

    摘要翻译： 由式“IMAGE”表示的苯甲酰胺衍生物，其中X表示低级烷氧基; Y表示一或二低级烷基氨基; Z表示卤原子; R1表示低级烷基; R2表示氢原子或卤素原子，以及它们的药理学上可接受的无毒性盐，其是强中枢神经系统抑制剂，特别是强抗精神病药。