摘要:
Pyrazine derivatives by the formula ##STR1## are disclosed. In the above formula, R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkoxy group, a phenyl lower alkoxy group, a phenoxy group, a mercapto group, a lower alkylthio group, a phenyl lower alkylthio group, a phenylthio group, an amino group, a substituted amino group, a lower alkyl group, a carbamoyl group or a sulfamoyl group; R.sup.3 represents a lower alkoxy group; R.sup.4, R.sup.5, and R.sup.6, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl lower alkyl group, or a phenyl group; and A represents a lower alkylene group; said R.sup.4 and A, said R.sup.5 and A, said R.sup.4 and R.sup.5, or said R.sup.5 and R.sup.6 may form a 5-membered or 6-membered nitrogen-containing heterocyclic ring which may further contain a hetero-atom together with nitrogen atom, and the pharmacologically acceptable non-toxic salts thereof. The compounds of this invention have a strong and selective antiematic activity and an effect of stimulating the gastric motility.
摘要:
There are disclosed novel 4-substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives represented by the formula: ##STR1## wherein X represents a halogen atom; Y represents a hydrogen atom or a halogen atom; R.sub.1 represents a lower alkyl group, a carbamoyl group, a mono- or di-lower alkyl-substituted carbamoyl group, a phenyl-substituted carbamoyl group, a lower alkoxycarbonyl group, a lower alkoxy-substituted lower alkoxycarbonyl group, a phenyl-substituted lower alkoxycarbonyl group, or a cycloalkyloxycarbonyl group; and R.sub.2 represents a lower alkyl group, a cycloalkyl group, or the group shown by the formula ##STR2## wherein R.sub.3 represents a hydrogen atom or a lower alkyl group and R.sub.4 represents a hydrogen atom, a hydroxy group, or a lower alkoxy group and the pharmaceutically acceptable nontoxic salts thereof.These compounds are antiasthmatic agents useful for the prophylaxis and treatment of asthma.
摘要翻译:公开了由下式表示的新型4-取代氨基-α-氨基甲基苄醇衍生物:其中X表示卤素原子; Y表示氢原子或卤素原子; R 1表示低级烷基,氨基甲酰基,一或二低级烷基取代的氨基甲酰基,苯基取代的氨基甲酰基,低级烷氧基羰基,低级烷氧基取代的低级烷氧基羰基,苯基取代的低级 烷氧基羰基或环烷氧基羰基; 和R 2表示低级烷基,环烷基或下式所示的基团,其中R 3表示氢原子或低级烷基,R 4表示氢原子,羟基或低级烷氧基, 其药学上可接受的无毒盐。
摘要:
2-(Indenyloxymethyl) morpholine derivatives are disclosed. These derivatives are excellent in methamphetamine stereotyped increasing and antireserpine activities which are useful as antidepression agents.
摘要:
There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-methylamino)ethyl ester and 5-methyl ester. The 1,4-dihydropyridine derivatives are characterized by cerebral vascular dilator activity.
摘要:
A process of preparing a .DELTA..sup.3 -cephalosporanic acid ester derivative which comrises reacting a cephalosporanic acid sulfoxide ester derivative with thionyl halide or a phosphorous halide.The compounds prepared by the process of this invention are useful as intermediate compounds for preparing cephalosporin antibiotics and the compounds themselves are also potential antibacterials.
摘要:
A process of preparing a .DELTA..sup.3 -cephalosporanic acid ester derivative which comprises reacting a cephalosporanic acid sulfoxide ester derivative with thionyl halide or a phosphorous halide.The compounds prepared by the process of this invention are useful as intermediate compounds for preparing cephalosporin antibiotics and the compounds themselves are also potential antibacterials.
摘要:
Novel .alpha.-aminomethylbenzyl alcohol derivatives, particularly .alpha.-aminoethyl-3-substituted amino-4-hydroxybenzyl alcohol derivatives. The compounds of this invention are useful as bronchodilating agents.