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公开(公告)号：US20210069377A1
公开(公告)日：2021-03-11
申请号：US17046187
申请日：2019-04-11
发明人： David Kershaw , Paulo Bartolo , Carl Diver , Enes Aslan , Cian Vyas , Iain Elder
摘要： Tissue scaffold matrices, and methods of their use, are described. The matrices comprise an enzyme that is able to convert a substrate to release hydrogen peroxide and a substrate for the enzyme. The matrices may be impregnated with cells, such as stem cells. Also described are cell cultures, and methods for proliferating and/or differentiating cells.
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公开(公告)号：US20200289701A1
公开(公告)日：2020-09-17
申请号：US16753570
申请日：2018-10-16
IPC分类号： A61L26/00 , A61K38/44 , A61K9/06 , A61K47/40 , A61K47/26 , A61K47/32 , A61K38/36 , A61K38/48
摘要： A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.
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公开(公告)号：US20230413826A1
公开(公告)日：2023-12-28
申请号：US18212471
申请日：2023-06-21
IPC分类号： A01N59/00 , A61K9/06 , A61K38/36 , A61K38/44 , A61K38/48 , A61K47/26 , A61K47/32 , A61K47/40 , A61L26/00 , A01N63/50
CPC分类号： A01N59/00 , A61K9/06 , A61K38/363 , A61K38/443 , A61K38/4833 , A61K47/26 , A61K47/32 , A61K47/40 , A61L26/0014 , A61L26/0042 , A61L26/0047 , A61L26/0066 , A61L26/008 , A61L26/0095 , A01N63/50 , C12Y101/03004
摘要： A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.
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公开(公告)号：US11730168B2
公开(公告)日：2023-08-22
申请号：US16753570
申请日：2018-10-16
IPC分类号： A61K38/44 , A61K38/48 , A61L26/00 , A01N63/50 , A01N59/00 , A61K9/06 , A61K38/36 , A61K47/26 , A61K47/32 , A61K47/40
CPC分类号： A01N59/00 , A01N63/50 , A61K9/06 , A61K38/363 , A61K38/443 , A61K38/4833 , A61K47/26 , A61K47/32 , A61K47/40 , A61L26/008 , A61L26/0014 , A61L26/0042 , A61L26/0047 , A61L26/0066 , A61L26/0095 , C12Y101/03004 , A01N63/50 , A01N25/04 , A01N25/10 , A01N25/14 , A01N43/16 , A01N59/00 , A01N63/50
摘要： A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.
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公开(公告)号：US20200069777A1
公开(公告)日：2020-03-05
申请号：US16347492
申请日：2017-11-15
摘要： Compositions for generating antimicrobial activity are described. The compositions comprise: a first phase; a second phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme, wherein the first phase and the second phase are immiscible. The compositions may be formulated as emulsions or creams. Methods of making the compositions are described, as well as their use for the treatment of antimicrobial infections.
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公开(公告)号：US20200030347A1
公开(公告)日：2020-01-30
申请号：US16337155
申请日：2017-10-06
发明人： David Kershaw , Matthew Dryden , Ian Staples , Sophie Constance Cox , Thomas Jon Hall , Liam Michael Grover , Rami Salib
IPC分类号： A61K31/7004 , A61K31/43 , A61K31/424 , A61K33/40 , A61K9/14 , A61K9/08
摘要： Compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, a substrate for the enzyme, and a solute in the form of a sugar or sugar derivative having a solubility of at least 100 g/100 g water at 20° C. and 1 atm. The compositions may not comprise sufficient free water to allow the enzyme to convert the substrate.
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公开(公告)号：US20200323963A1
公开(公告)日：2020-10-15
申请号：US16092410
申请日：2017-04-12
发明人： Paulo Bartolo , Carl Diver , Ian Staples , Annette Callaghan , Iain Elder , Matthew Dryden , David Kershaw , Rami Salib
IPC分类号： A61K38/44 , A61K47/34 , A61K47/46 , A61L15/40 , A61L15/38 , A61L15/26 , A61K9/70 , A61L15/44 , D01F6/62 , D04H3/007 , D01F8/18 , D01F8/06
摘要： Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions for forming such fibers are also described, as is the use of the fibers, wound dressings and compositions.
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