公开(公告)号：US20070010544A1

公开(公告)日：2007-01-11

申请号：US11477745

申请日：2006-06-28

申请人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun

发明人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun

IPC分类号： C07D471/02 ,  A61K31/4745

CPC分类号： C07D491/052

摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

公开(公告)号：US07432276B2

公开(公告)日：2008-10-07

申请号：US11646691

申请日：2006-12-27

申请人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun ,  Melanie Boze

发明人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun ,  Melanie Boze

IPC分类号： A61K31/4741 ,  C07D491/06

CPC分类号： C07D491/052

摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

摘要翻译： 本发明提供了可用于增加哺乳动物中细胞ATP结合盒转运蛋白ABCA1产生的化合物，以及使用这些化合物治疗冠状动脉疾病，血脂异常和代谢综合征的方法。 本发明还涉及制备这些化合物的方法以及含有它们的药物组合物。

公开(公告)号：US07423045B2

公开(公告)日：2008-09-09

申请号：US11477745

申请日：2006-06-28

申请人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun

发明人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun

IPC分类号： A61K31/4741 ,  C07D491/06

CPC分类号： C07D491/052

摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

公开(公告)号：US20080293757A1

公开(公告)日：2008-11-27

申请号：US12187245

申请日：2008-08-06

申请人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun

发明人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun

IPC分类号： A61K31/4745 ,  C07D471/02 ,  A61P9/00

CPC分类号： C07D491/052

摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

摘要翻译： 本发明提供了可用于增加哺乳动物中细胞ATP结合盒转运蛋白ABCA1产生的化合物，以及使用这些化合物治疗冠状动脉疾病，血脂异常和代谢综合征的方法。 本发明还涉及制备这些化合物的方法以及含有它们的药物组合物。

公开(公告)号：US20070191379A1

公开(公告)日：2007-08-16

申请号：US11646691

申请日：2006-12-27

申请人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun ,  Melanie Boze

发明人： Matthew Abelman ,  Robert Jiang ,  Jeff Zablocki ,  Dmitry Koltun ,  Melanie Boze

IPC分类号： A61K31/498 ,  A61K31/4745 ,  A61K31/4741 ,  C07D491/02

CPC分类号： C07D491/052

摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

公开(公告)号：US08754103B2

公开(公告)日：2014-06-17

申请号：US12843702

申请日：2010-07-26

申请人： Britton Corkey ,  Elfatih Elzein ,  Robert Jiang ,  Rao Kalla ,  Tetsuya Kobayashi ,  Dmitry Koltun ,  Xiaofen Li ,  Gregory Notte ,  Eric Parkhill ,  Thao Perry ,  Jeff Zablocki

发明人： Britton Corkey ,  Elfatih Elzein ,  Robert Jiang ,  Rao Kalla ,  Tetsuya Kobayashi ,  Dmitry Koltun ,  Xiaofen Li ,  Gregory Notte ,  Eric Parkhill ,  Thao Perry ,  Jeff Zablocki

IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D491/02

摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

公开(公告)号：US06900219B2

公开(公告)日：2005-05-31

申请号：US10407875

申请日：2003-04-04

申请人： Prabha Ibrahim ,  Michael Campbell ,  Robert Jiang ,  Christopher Morrison ,  Kevin Shenk ,  William Shirley ,  Jeff Zablocki ,  Dmitry Koltun ,  Reina Natero

发明人： Prabha Ibrahim ,  Michael Campbell ,  Robert Jiang ,  Christopher Morrison ,  Kevin Shenk ,  William Shirley ,  Jeff Zablocki ,  Dmitry Koltun ,  Reina Natero

IPC分类号： A61K31/427 ,  A61K31/428 ,  A61K31/517 ,  A61P9/10 ,  A61K31/415 ,  A61K31/425

CPC分类号： A61K31/517 ,  A61K31/427 ,  A61K31/428

摘要： The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.

公开(公告)号：US20110021521A1

公开(公告)日：2011-01-27

申请号：US12843702

申请日：2010-07-26

申请人： Britton Corkey ,  Elfatih Elzein ,  Robert Jiang ,  Rao Kalla ,  Tetsuya Kobayashi ,  Dmitry Koltun ,  Xiaofen Li ,  Gregory Notte ,  Eric Parkhill ,  Thao Perry ,  Jeff Zablocki

发明人： Britton Corkey ,  Elfatih Elzein ,  Robert Jiang ,  Rao Kalla ,  Tetsuya Kobayashi ,  Dmitry Koltun ,  Xiaofen Li ,  Gregory Notte ,  Eric Parkhill ,  Thao Perry ,  Jeff Zablocki

IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61K31/437 ,  C07D487/04 ,  A61K31/5025 ,  A61K31/519 ,  C07D413/14 ,  C07D403/14 ,  A61K31/501 ,  A61P25/08 ,  A61P29/00 ,  A61P9/00 ,  A61P3/10

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式I给出：其中W1，W2，W3，R1，Q，X1，X2和X3如本文所述，用于制备和使用化合物和药物组合物的方法 含有相同的

公开(公告)号：US09371329B2

公开(公告)日：2016-06-21

申请号：US14274422

申请日：2014-05-09

申请人： Britton Corkey ,  Elfatih Elzein ,  Robert Jiang ,  Rao Kalla ,  Tetsuya Kobayashi ,  Dmitry Koltun ,  Xiaofen Li ,  Gregory Notte ,  Eric Parkhill ,  Thao Perry ,  Jeff Zablocki

发明人： Britton Corkey ,  Elfatih Elzein ,  Robert Jiang ,  Rao Kalla ,  Tetsuya Kobayashi ,  Dmitry Koltun ,  Xiaofen Li ,  Gregory Notte ,  Eric Parkhill ,  Thao Perry ,  Jeff Zablocki

IPC分类号： C07D487/04 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

公开(公告)号：US20140303158A1

公开(公告)日：2014-10-09

申请号：US14274422

申请日：2014-05-09

申请人： Britton Corkey ,  Elfatih Elzein ,  Robert Jiang ,  Rao Kalla ,  Tetsuya Kobayashi ,  Dmitry Koltun ,  Xiaofen Li ,  Gregory Notte ,  Eric Parkhill ,  Thao Perry ,  Jeff Zablocki

发明人： Britton Corkey ,  Elfatih Elzein ,  Robert Jiang ,  Rao Kalla ,  Tetsuya Kobayashi ,  Dmitry Koltun ,  Xiaofen Li ,  Gregory Notte ,  Eric Parkhill ,  Thao Perry ,  Jeff Zablocki

IPC分类号： C07D487/04 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式I给出：其中W1，W2，W3，R1，Q，X1，X2和X3如本文所述，用于制备和使用化合物和药物组合物的方法 含有相同的